INT107812

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.54
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa, Sst) extracellular space (Sst) nucleus (Nppa)
cytoplasm (Nppa)
Anatomy Link Frequency
stomach 4
Nppa (Rattus norvegicus)
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 56 100.00 Very High Very High Very High
antagonist 8 95.80 Very High Very High Very High
tetrodotoxin 4 93.40 High High
Disease Link Frequency Relevance Heat
Natriuresis 8 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anantin alone inhibited somatostatin secretion by 18+/-3% (P<0.005), implying that endogenous ANP, acting via the NPR-A receptor, stimulates somatostatin secretion.
ANP Positive_regulation (stimulates) of Localization (secretion) of somatostatin associated with somatostatin
1) Confidence 0.48 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.15 Pain Relevance 0.75
We conclude that antral ANP and somatostatin secretion are linked by paracrine feedback pathways: endogenous ANP, acting via the NPR-A receptor, stimulates somatostatin secretion, and endogenous somatostatin, acting via the sst2 receptor, inhibits ANP secretion.
ANP Positive_regulation (stimulates) of Localization (secretion) of somatostatin associated with somatostatin
2) Confidence 0.48 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.07 Pain Relevance 0.73
In the present study, we have superfused antral mucosal segments obtained from rat stomach to examine the paracrine pathways linking ANP and somatostatin secretion in this region.ANP (0.1 pM to 0.1 microM) caused a concentration-dependent increase in somatostatin secretion (EC(50), 0.3 nM).
ANP Positive_regulation (caused) of Localization (secretion) of somatostatin in stomach associated with somatostatin
3) Confidence 0.42 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.55
In the present study, we have superfused antral mucosal segments obtained from rat stomach to examine the paracrine pathways linking ANP and somatostatin secretion in this region.ANP (0.1 pM to 0.1 microM) caused a concentration-dependent increase in somatostatin secretion (EC(50), 0.3 nM).
ANP Positive_regulation (caused) of Spec (examine) Localization (secretion) of somatostatin in stomach associated with somatostatin
4) Confidence 0.42 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.48

General Comments

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