INT10783

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 29
Disease Relevance 7.90
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1)
Anatomy Link Frequency
neurons 13
neuronal 2
hinge 2
gonadal 1
pituitary 1
Gnrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 9 99.92 Very High Very High Very High
Action potential 8 99.62 Very High Very High Very High
gABA 80 99.54 Very High Very High Very High
depression 48 98.76 Very High Very High Very High
tetrodotoxin 11 98.36 Very High Very High Very High
Analgesic 2 98.20 Very High Very High Very High
agonist 29 98.08 Very High Very High Very High
Dismenorea 4 97.68 Very High Very High Very High
opiate 10 96.56 Very High Very High Very High
GABAergic 25 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 8 99.72 Very High Very High Very High
Stress 72 99.64 Very High Very High Very High
Aids-related Complex 486 99.62 Very High Very High Very High
Mitral Valve Prolapse 10 99.60 Very High Very High Very High
Depression 77 98.76 Very High Very High Very High
Solid Tumor 2 98.72 Very High Very High Very High
Congenital Anomalies 12 97.96 Very High Very High Very High
Dysmenorrhea 4 97.68 Very High Very High Very High
Reprotox - General 1 10 96.64 Very High Very High Very High
Cancer 25 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the LHRH system appears to play an important role in preventing precocious activation of the hypothalamic-pituitary-gonadal axis.
Negative_regulation (Inhibition) of LHRH in gonadal
1) Confidence 0.59 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.24
In contrast, LHRH mRNA levels decreased in explants cultured with the GABA(A) receptor agonist, muscimol (10(-4) M), or KCl (50 mM).
Negative_regulation (decreased) of LHRH mRNA associated with gaba and agonist
2) Confidence 0.59 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.62
Evidence points to gamma-aminobutyric acid (GABA) as the major negative regulator of postnatal LHRH neuronal activity.
Negative_regulation (regulator) of LHRH in neuronal associated with gaba
3) Confidence 0.43 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.29
Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors.
Negative_regulation (decrease) of LHRH in neurons associated with gaba
4) Confidence 0.43 Published 1998 Journal Endocrinology Section Title Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.40
The present study addresses this matter further by investigating the maturation of both female and male hypothalamic kisspeptin in a background of GnRH deficiency.
Negative_regulation (deficiency) of GnRH
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.13 Pain Relevance 0
Intact hpg mice had significantly fewer kisspeptin-positive neurons (30.4±1.7 neurons/section) than intact WT mice (P<0.05; Neuman-Keuls post-hoc), and OVX did not result in any further decrease in the hpg AVPV kisspeptin-positive neuronal population (32.0±4.1 neurons/section) (Fig. 7A, B).
Negative_regulation (decrease) of hpg in neuronal
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0 Pain Relevance 0
In order to better understand sex steroid hormone-dependent and -independent effects on the maturation of kisspeptin neurons, hypogonadal (hpg) mice deficient in GnRH and its downstream effectors were used to determine changes in the developmental kisspeptin expression.
Negative_regulation (deficient) of GnRH in neurons
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912854 Disease Relevance 0.06 Pain Relevance 0
Intraperitoneal treatment with an analogue of gonadotropin-releasing hormone in doses of 0.004-450 microg/kg produced an analgesic effect on male mice in the hot plate test.
Negative_regulation (analogue) of gonadotropin-releasing hormone associated with analgesic
8) Confidence 0.43 Published 2006 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 16984094 Disease Relevance 0.16 Pain Relevance 0.10
The amplitude of the sodium current underlying the action potential was significantly decreased in GnRH neurons from young estradiol-treated animals.
Negative_regulation (decreased) of GnRH in neurons associated with action potential
9) Confidence 0.43 Published 2010 Journal Brain Res. Section Abstract Doc Link 20580637 Disease Relevance 0 Pain Relevance 0.21
We have previously shown that estradiol administered to the female mouse decreases inward currents in fluorescently labeled GnRH neurons.
Negative_regulation (decreases) of GnRH in neurons
10) Confidence 0.43 Published 2010 Journal Brain Res. Section Abstract Doc Link 20580637 Disease Relevance 0 Pain Relevance 0.11
However, the extent to which GABA acts directly on LHRH neurons to effect LHRH mRNA levels has been difficult to ascertain.
Negative_regulation (effect) of LHRH mRNA in neurons associated with gaba
11) Confidence 0.43 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.37
Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors.
Negative_regulation (decrease) of Luteinizing hormone releasing hormone in neurons associated with gaba
12) Confidence 0.43 Published 1998 Journal Endocrinology Section Title Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.40
However, marked heterogeneity in the sensitivity of individual juvenile GnRH neurons to GABA was revealed and, in parallel with the change in subunit mRNA profile, this was dramatically reduced in the reproductively competent adult GnRH neurons.
Negative_regulation (reduced) of GnRH in neurons associated with gaba
13) Confidence 0.43 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.34
It is also possible that the inhibition of GnRH release could be due to a decrease in the tonic stimulatory action of noradrenergic pathway implicated in the control of GnRH release.
Negative_regulation (inhibition) of GnRH
14) Confidence 0.43 Published 2002 Journal Life Sci. Section Abstract Doc Link 12127906 Disease Relevance 0.16 Pain Relevance 0.31
Inhibiting leptin receptor signaling pathways within GnRH neurons abolished the latter effect, indicating a direct action on these cells.
Negative_regulation (Inhibiting) of GnRH in neurons
15) Confidence 0.42 Published 2004 Journal Endocrinology Section Abstract Doc Link 14645118 Disease Relevance 0.37 Pain Relevance 0.82
Negative energy balance inhibits fertility by decreasing GnRH release; however, the mechanisms are not well understood.
Negative_regulation (decreasing) of GnRH
16) Confidence 0.42 Published 2004 Journal Endocrinology Section Abstract Doc Link 14645118 Disease Relevance 0.05 Pain Relevance 0.32
The depolarizing response to bicuculline persisted in the presence of tetrodotoxin, demonstrating that even action potential-independent GABA release was acting to reduce GnRH neuron membrane potential.
Negative_regulation (reduce) of GnRH in neuron associated with action potential, tetrodotoxin and gaba
17) Confidence 0.42 Published 2004 Journal Endocrinology Section Abstract Doc Link 14617578 Disease Relevance 0.08 Pain Relevance 0.44
Intact and castrated mice with different testosterone levels (3-9 ng/mL) were challenged with exogenous GnRH while under general anesthesia to block endogenous GnRH release.
Negative_regulation (block) of GnRH associated with anesthesia
18) Confidence 0.41 Published 2001 Journal J. Androl. Section Abstract Doc Link 11330652 Disease Relevance 0 Pain Relevance 0.10
The results showed that after GnRH was inhibited by anti-GnRH antibodies the testosterone levels in sera markedly decreased (P<0.01) and the testicle weights reduced as well (P<0.05) in GnRH(3)-hinge-MVP-Hsp65-immunized mice.
Negative_regulation (inhibited) of GnRH in hinge associated with mitral valve prolapse
19) Confidence 0.41 Published 2007 Journal Vaccine Section Abstract Doc Link 17728021 Disease Relevance 0.98 Pain Relevance 0.05
The results showed that after GnRH was inhibited by anti-GnRH antibodies the testosterone levels in sera markedly decreased (P<0.01) and the testicle weights reduced as well (P<0.05) in GnRH(3)-hinge-MVP-Hsp65-immunized mice.
Negative_regulation (reduced) of GnRH in hinge associated with mitral valve prolapse
20) Confidence 0.41 Published 2007 Journal Vaccine Section Abstract Doc Link 17728021 Disease Relevance 1.00 Pain Relevance 0.06

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