INT107843

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
brain 2
Plc (Apis mellifera)
Pain Term Frequency Confidence Heat
antidepressant 16 99.00 Very High Very High Very High
Desipramine 2 91.68 High High
fluoxetine 2 90.16 High High
Hippocampus 6 81.04 Quite High
Disease Term Frequency Confidence Heat
Anxiety Disorder 6 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI-specific phospholipase C (PLC), and whether this represents a common mechanism of action of antidepressants, we determined the effects of antidepressants of various classes on PI-PLC activity and on the expression of PLC isozymes in rat brain.
Gene_expression (expression) of PLC in brain associated with antidepressant
1) Confidence 0.03 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527476 Disease Relevance 0.12 Pain Relevance 0.45
Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain.
Gene_expression (expression) of PLC in brain associated with antidepressant
2) Confidence 0.03 Published 2002 Journal Neuropharmacology Section Title Doc Link 12527476 Disease Relevance 0.13 Pain Relevance 0.46

General Comments

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