INT107846

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.06
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
ileum 1
monocytes 1
nociceptors 1
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 3 99.92 Very High Very High Very High
nociceptor 44 98.32 Very High Very High Very High
Root ganglion neuron 2 97.48 Very High Very High Very High
Thermal hyperalgesia 4 93.12 High High
agonist 11 92.84 High High
antagonist 6 92.48 High High
Inflammatory response 6 85.24 High High
low threshold mechanoreceptor 4 83.16 Quite High
Pain 8 83.00 Quite High
adenocard 35 81.80 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 99.16 Very High Very High Very High
Ganglion Cysts 15 97.16 Very High Very High Very High
Hyperalgesia 10 93.12 High High
INFLAMMATION 26 84.84 Quite High
Pain 6 83.00 Quite High
Rheumatoid Arthritis 34 79.28 Quite High
Obesity 1 78.56 Quite High
Hypersensitivity 2 75.00 Quite High
Stroke 4 73.96 Quite High
Injury 5 68.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of a role for P2Y ATP receptors in macrophage function, and consistent with our data, P2ry1 and P2ry2 mRNAs were expressed at high levels in macrophages and LPS-stimulated monocytes [31].
Transcription (expressed) of P2ry2 in monocytes
1) Confidence 0.46 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0.13
P2Y(1) mRNA was localized in neurones in both myenteric and submucosal ganglia in the ileum.
Transcription (localized) of P2Y in ileum
2) Confidence 0.37 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527481 Disease Relevance 0 Pain Relevance 0.48
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Transcription (mRNA) of P2Y2
3) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.51
Coexpression of TRPV1 mRNA with P2Y2 mRNA, but not P2Y1 mRNA, was determined in the rat lumbar DRG using in situ hybridization histochemistry.
Transcription (Coexpression) of P2Y2
4) Confidence 0.36 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.50 Pain Relevance 0.52
Quantification of the P2Y2 receptor did not show differences in the level of gene expression in the two groups, indicating that type 2 diabetes does not affect the rate and way of mRNA expression of the P2Y2 receptor gene.
Transcription (expression) of P2Y2 associated with diabetes mellitus
5) Confidence 0.32 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.77 Pain Relevance 0.09
A role for P2Y2 receptors is also in good agreement with previous reports showing high levels of P2Y2 mRNA in almost 90% of all small diameter nociceptors but only in one-third of large diameter sensory neurones the identity of which is unknown (Molliver et al. 2002).
Transcription (levels) of P2Y2 in nociceptors associated with nociceptor
6) Confidence 0.25 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.20 Pain Relevance 0.80

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox