INT10785

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Context Info
Confidence 0.78
First Reported 1937
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 20.64
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 5
Thyroid 4
pituitary 4
colon 2
blood 2
Prl (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 99.80 Very High Very High Very High
Dismenorea 34 99.10 Very High Very High Very High
Glutamate 21 99.00 Very High Very High Very High
cva 58 97.92 Very High Very High Very High
opiate 4 96.80 Very High Very High Very High
Multiple sclerosis 135 96.56 Very High Very High Very High
antagonist 26 96.24 Very High Very High Very High
addiction 1 96.16 Very High Very High Very High
Somatostatin 61 95.96 Very High Very High Very High
agonist 10 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 820 100.00 Very High Very High Very High
Targeted Disruption 71 99.68 Very High Very High Very High
Salivary Gland Disease 16 99.64 Very High Very High Very High
Reprotox - General 1 16 99.48 Very High Very High Very High
Colon Cancer 18 99.32 Very High Very High Very High
Dysmenorrhea 33 99.10 Very High Very High Very High
Sprains And Strains 219 98.82 Very High Very High Very High
Pressure And Volume Under Development 9 98.16 Very High Very High Very High
Hemorrhage 63 97.92 Very High Very High Very High
Carcinoid 60 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum PRL levels in recipients rose within 3 weeks to levels seen during pregnancy, resulting in a premature increase in serum progesterone (P) levels.
Gene_expression (levels) of PRL
1) Confidence 0.78 Published 1985 Journal Endocrinology Section Abstract Doc Link 3971922 Disease Relevance 0.35 Pain Relevance 0.13
The grafts in the hybrids routinely became adenomatous, producing serm PRL levels of 1-21 X 10(3) ng/ml; only one secreted excessive GH.
Gene_expression (producing) of PRL
2) Confidence 0.78 Published 1985 Journal Endocrinology Section Abstract Doc Link 3971922 Disease Relevance 0.74 Pain Relevance 0.24
As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and the pattern of estrous cycles were determined in SHN virgin mice.
Gene_expression (levels) of PRL in plasma associated with glutamate
3) Confidence 0.76 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.31 Pain Relevance 0.45
The grafts in the hybrids routinely became adenomatous, producing serm PRL levels of 1-21 X 10(3) ng/ml; only one secreted excessive GH.
Gene_expression (levels) of PRL
4) Confidence 0.68 Published 1985 Journal Endocrinology Section Abstract Doc Link 3971922 Disease Relevance 0.74 Pain Relevance 0.24
Furthermore, our results suggest that the use of prolactin, which did not produce any adverse hemodynamic effects, represents a novel and safe immunomodulating hormone for the treatment of immunodepression following severe blood loss.
Neg (not) Gene_expression (produce) of prolactin in blood associated with pressure volume 2 under development
5) Confidence 0.66 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8661172 Disease Relevance 0.51 Pain Relevance 0.21
Two hours following saline or prolactin injection, splenocytes (SPL) were harvested and assessed for proliferative capacity (PC) and their ability to release IL-2 and IL-3.
Gene_expression (injection) of prolactin
6) Confidence 0.66 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8661172 Disease Relevance 0.34 Pain Relevance 0.25
In contrast, plasma PRL levels and the pattern of estrous cycles were little affected by the treatment.
Gene_expression (levels) of PRL in plasma
7) Confidence 0.66 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.33 Pain Relevance 0.59
Prolactin may produce anovulatory cycles in women and thus provide a method of hormonal sterilization. 4 mg progesterone daily inhibits estrus.
Gene_expression (produce) of Prolactin
8) Confidence 0.62 Published 1937 Journal J Contracept Section Abstract Doc Link 12255369 Disease Relevance 0.24 Pain Relevance 0.08
It has been shown in mice that progesterone stimulates both mammary tumourigenesis and uterine adenomyosis in intact animals in the presence of normal levels of prolactin and oestrogen.
Gene_expression (levels) of prolactin in uterine associated with dismenorea
9) Confidence 0.60 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817809 Disease Relevance 0.23 Pain Relevance 0.27
On further purification with silica gel, Casticin was isolated from this fraction and it decreased abnormal serum levels of prolactin by approximately 50% (p < 0.01).
Gene_expression (levels) of prolactin
10) Confidence 0.60 Published 2007 Journal Phytomedicine Section Abstract Doc Link 17350238 Disease Relevance 0.63 Pain Relevance 0.08
Furthermore, the treatment with danazol resulted in the decrease of serum levels of luteinizing hormone (LH) and prolactin (PRL) associated with hypofunction of ovaries and persistent diestrus.
Gene_expression (levels) of prolactin in ovaries
11) Confidence 0.60 Published 1992 Journal Life Sci. Section Abstract Doc Link 1518375 Disease Relevance 0.42 Pain Relevance 0.34
Furthermore, the treatment with danazol resulted in the decrease of serum levels of luteinizing hormone (LH) and prolactin (PRL) associated with hypofunction of ovaries and persistent diestrus.
Gene_expression (levels) of PRL in ovaries
12) Confidence 0.60 Published 1992 Journal Life Sci. Section Abstract Doc Link 1518375 Disease Relevance 0.42 Pain Relevance 0.34
As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and the pattern of estrous cycles were determined in SHN virgin mice.
Gene_expression (levels) of prolactin in plasma associated with glutamate
13) Confidence 0.59 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.31 Pain Relevance 0.45
Serum prolactin, growth hormone, progesteron, and insulin-like growth factor-I levels
Gene_expression (levels) of prolactin
14) Confidence 0.39 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.51 Pain Relevance 0
However, in our study, prolactin levels were similar in C57BL/6 and BALB/c mice and in progestin-treated animals of both strains.
Gene_expression (levels) of prolactin associated with sprains and strains
15) Confidence 0.39 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.71 Pain Relevance 0
Serum prolactin, growth hormone, progesteron, and insulin-like growth factor-I levels
Gene_expression (progesteron) of prolactin
16) Confidence 0.39 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.50 Pain Relevance 0
To explore the possibility of pituitary dysfunction as an explanation for the strain differences in hormone responsiveness, we evaluated serum levels of prolactin in control and progestin-treated mice, but we failed to observe any difference between C57BL/6 and BALB/c mice.
Gene_expression (levels) of prolactin in pituitary associated with sprains and strains
17) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.69 Pain Relevance 0
Pernicone et al. [4] reported a clinicopathologic study of 15 patients with pituitary carcinomas in which the overall latency period ranged from just over three months to 18 years (median 5 years); the latency was nearly twice as long for ACTH-producing tumors as for prolactin (PRL) tumors (9.5 vs. 4.7 years).
Gene_expression (producing) of PRL in pituitary associated with cancer and pituitary cancer
18) Confidence 0.34 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.62 Pain Relevance 0.03
Pernicone et al. [4] reported a clinicopathologic study of 15 patients with pituitary carcinomas in which the overall latency period ranged from just over three months to 18 years (median 5 years); the latency was nearly twice as long for ACTH-producing tumors as for prolactin (PRL) tumors (9.5 vs. 4.7 years).
Gene_expression (producing) of prolactin in pituitary associated with cancer and pituitary cancer
19) Confidence 0.29 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.61 Pain Relevance 0.03
Fig. 3Dynamic GH (circles) and PRL (triangles) tests in two patients with a GHRH-secreting lung carcinoid before (closed symbols) and after surgery (open symbols).
Gene_expression (circles) of PRL in lung associated with carcinoid
20) Confidence 0.28 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.47 Pain Relevance 0

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