INT107858

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 4.23
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
mast cell 2
Kidney 1
PRSS1 (Homo sapiens)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 69 97.80 Very High Very High Very High
Inflammation 148 97.48 Very High Very High Very High
cytokine 41 77.52 Quite High
Hyperalgesia 3 76.24 Quite High
Arthritis 13 75.32 Quite High
fibrosis 16 75.00 Quite High
Bile 7 71.84 Quite High
antagonist 15 68.48 Quite High
Osteoarthritis 66 67.88 Quite High
Thermal hyperalgesia 1 66.72 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 98.96 Very High Very High Very High
INFLAMMATION 157 97.48 Very High Very High Very High
Pancreatic Cancer 12 96.48 Very High Very High Very High
Colitis 4 92.08 High High
Apoptosis 2 89.32 High High
Inflammatory Bowel Disease 3 89.12 High High
Cancer 52 88.48 High High
Metastasis 8 86.00 High High
Pathologic Processes 1 85.28 High High
Malignant Neoplastic Disease 4 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin.
trypsin Positive_regulation (activated) of proteinase-activated receptor-2
1) Confidence 0.12 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 0.69 Pain Relevance 0.04
The proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin.
trypsin Positive_regulation (activated) of PAR-2
2) Confidence 0.08 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12527925 Disease Relevance 0.69 Pain Relevance 0.04
PAR2 is activated by mainly serine proteases (e.g. trypsin, tryptase, cathepsin G) but not thrombin and may be linked to inflammatory and proliferative disorders [4].
trypsin Positive_regulation (activated) of PAR2 associated with inflammation
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.61 Pain Relevance 0.23
Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293), a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2) and a PAR2 activating hexapeptide (2f-LIGRLO-NH2).
trypsin Positive_regulation (activates) of PAR2 in Kidney
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.68 Pain Relevance 0.35
PAR-1, PAR-3, and PAR-4 are activated by thrombin, whereas PAR-2 is activated mainly by trypsin but also by mast cell tryptase.
trypsin Positive_regulation (activated) of PAR-2 in mast cell
5) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.76 Pain Relevance 0.49
However, to our surprise we found that activation of PAR2 by trypsin or the specific activating peptide SLIGKV-OH strongly inhibited both the phosphorylation and activity of JNK.
trypsin Positive_regulation (activation) of PAR2
6) Confidence 0.01 Published 2010 Journal Cellular Signalling Section Abstract Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
Of the four family members, PAR1, PAR3, and PAR4 are primarily activated by thrombin while PAR2 is activated by trypsin, mast cell tryptase, and clotting factors VIIa and Xa.
trypsin Positive_regulation (activated) of PAR2 in mast cell associated with coagulation disorder
7) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.81 Pain Relevance 0.08

General Comments

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