INT107860

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 6.36
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
chondrocytes 4
cartilage 4
epithelial cells 4
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 396 99.84 Very High Very High Very High
fibrosis 11 99.84 Very High Very High Very High
cytokine 86 99.78 Very High Very High Very High
agonist 154 99.16 Very High Very High Very High
Inflammation 256 98.34 Very High Very High Very High
metalloproteinase 144 97.12 Very High Very High Very High
Inflammatory mediators 24 95.60 Very High Very High Very High
Arthritis 34 80.76 Quite High
rheumatoid arthritis 6 77.20 Quite High
COX2 22 76.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 110 100.00 Very High Very High Very High
Pancreatic Cancer 6 100.00 Very High Very High Very High
Osteoarthritis 402 99.84 Very High Very High Very High
Fibrosis 7 99.84 Very High Very High Very High
INFLAMMATION 282 98.34 Very High Very High Very High
Disease 54 95.56 Very High Very High Very High
Necrosis 20 89.44 High High
Malignant Neoplastic Disease 2 83.52 Quite High
Targeted Disruption 14 82.84 Quite High
Arthritis 34 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we showed that PAR-2 expression and protein levels were significantly increased in OA compared with normal human chondrocytes and that the levels are upregulated by the proinflammatory cytokines IL-1?
Positive_regulation (increased) of Gene_expression (expression) of PAR-2 in chondrocytes associated with osteoarthritis and cytokine
1) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.44 Pain Relevance 0.22
The important inflammatory mediator cyclooxygenase-2 (COX-2) has recently been reported to be activated with induced PAR2 expression and activation in gastric epithelial cells [41].
Positive_regulation (induced) of Gene_expression (expression) of PAR2 in epithelial cells associated with inflammation
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.28 Pain Relevance 0.31
The effects eventually returned to baseline 12 h after stimulation, but were significant enough to qualify as evidence that PAR2 expression was upregulated in response to PAR2 agonists.
Positive_regulation (upregulated) of Gene_expression (expression) of PAR2 associated with agonist
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.12
PAR2 activation induces PAR2 expression
Positive_regulation (induces) of Gene_expression (expression) of PAR2
4) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.23 Pain Relevance 0.14
Expression of proteinase-activated receptor-2 in human pancreatic cancer: a possible relation to cancer invasion and induction of fibrosis.
Positive_regulation (induction) of Gene_expression (Expression) of proteinase-activated receptor-2 associated with fibrosis, cancer and pancreatic cancer
5) Confidence 0.50 Published 2003 Journal Int. J. Oncol. Section Title Doc Link 12527925 Disease Relevance 1.14 Pain Relevance 0.25
1 on OA chondrocytes, but not on OA cartilage explants, upregulates PAR-2 levels appear contradictory.
Positive_regulation (upregulates) of Gene_expression (levels) of PAR-2 in cartilage associated with osteoarthritis
6) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.50 Pain Relevance 0.29
We showed that PAR-2 is present at increased levels in human OA cartilage and that its level is modulated by the proinflammatory cytokines interleukin 1 beta (IL-1?)
Positive_regulation (increased) of Gene_expression (present) of PAR-2 in cartilage associated with osteoarthritis and cytokine
7) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.35 Pain Relevance 0.75
Interestingly, PAR-2-AP appeared to be more efficient at increasing the level of PAR-2 protein than the cytokines, and mean increases of 53%, 64%, and 63% were found for PAR-2-AP 10, 100, and 400 ?
Positive_regulation (increases) of Gene_expression (found) of PAR-2-AP associated with cytokine
8) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.72 Pain Relevance 0.49
Data showed that on both sets this factor markedly increased PAR-2 expression levels (20- and 42-fold, respectively; data not shown).
Positive_regulation (increased) of Gene_expression (expression) of PAR-2
9) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.72 Pain Relevance 0.42
PAR-2 is produced by human chondrocytes and is significantly upregulated in OA compared with normal chondrocytes (p < 0.04 and p < 0.03, respectively).
Positive_regulation (upregulated) of Gene_expression (produced) of PAR-2 in chondrocytes associated with osteoarthritis
10) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.71 Pain Relevance 0.47
The important inflammatory mediator cyclooxygenase-2 (COX-2) has recently been reported to be activated with induced PAR2 expression and activation in gastric epithelial cells [41].
Positive_regulation (induced) of Gene_expression (expression) of PAR2 in epithelial cells associated with inflammation
11) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.28 Pain Relevance 0.31
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (-) of Gene_expression (found) of PAR2
12) Confidence 0.36 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06
NCTC2544-PAR2 cells were found to express the PKC isoforms, PKC?
Positive_regulation (NCTC2544) of Gene_expression (found) of PAR2
13) Confidence 0.36 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.06

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