INT10787

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 64
Total Number 82
Disease Relevance 23.06
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1)
Anatomy Link Frequency
neurons 30
olfactory 2
neuronal 2
gonadal 2
olfactory sensory neurons 2
Gnrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 106 100.00 Very High Very High Very High
Calcium channel 4 99.90 Very High Very High Very High
gABA 47 99.64 Very High Very High Very High
narcan 5 99.60 Very High Very High Very High
GABAergic 14 99.26 Very High Very High Very High
depression 75 99.10 Very High Very High Very High
agonist 38 98.60 Very High Very High Very High
Fibrositis 79 98.38 Very High Very High Very High
Somatostatin 38 97.80 Very High Very High Very High
antagonist 59 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1539 100.00 Very High Very High Very High
Targeted Disruption 111 100.00 Very High Very High Very High
Disease 585 99.92 Very High Very High Very High
Depression 110 99.82 Very High Very High Very High
Virilism 75 99.42 Very High Very High Very High
Chronic Fatigue Syndrome 191 98.84 Very High Very High Very High
Fibromyalgia 77 98.38 Very High Very High Very High
Congenital Anomalies 50 98.36 Very High Very High Very High
Solid Tumor 1 98.28 Very High Very High Very High
Dysmenorrhea 4 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such mice are unable to produce gonadotrophin releasing hormone (GnRH) due to a truncation in the GnRH gene, and therefore show a profound hypogonadotrophic hypogonadism [[5] for review].
Neg (unable) Gene_expression (produce) of GnRH associated with reprotox - general 2
1) Confidence 0.78 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.28 Pain Relevance 0
The present work evaluates the effect of GABAergic activity, via GABA(A) receptors, on LHRH neuropeptide gene expression in LHRH neurons maintained in olfactory explants generated from E11.5 mouse embryos.
Gene_expression (expression) of LHRH neuropeptide gene in olfactory associated with gaba, gabaergic and neuropeptide
2) Confidence 0.78 Published 1998 Journal Endocrinology Section Abstract Doc Link 9607779 Disease Relevance 0 Pain Relevance 0.48
Therefore, the hormone-independent increase in hpg kisspeptin expression in the region of the ARC nucleus is consistent with studies that have classically demonstrated that the central mechanisms regulating the onset of puberty are not gonad dependent [32], [33], [34].
Gene_expression (expression) of hpg in gonad associated with aids-related complex
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.51 Pain Relevance 0
The hypogonadal (hpg) mouse has a large deletion in the Gnrh1 gene, resulting in failure to synthesize GnRH [15].
Neg (failure) Gene_expression (synthesize) of GnRH
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.12 Pain Relevance 0
We and other research groups have exploited the hypogonadal (hpg) mouse [8], which cannot produce mature GnRH decapeptide due to a truncation in the GnRH gene, as a model to study the role of estrogen in male reproductive function [9,10].
Neg (cannot) Gene_expression (produce) of GnRH
5) Confidence 0.77 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.24 Pain Relevance 0
In previous work, such a loss has also been reported but not investigated in the hypothalamus of Necdin mutants (oxytocin- and LHRH-expressing neurons) [21].
Gene_expression (expressing) of LHRH in neurons
6) Confidence 0.75 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.71 Pain Relevance 0
These results demonstrate that nm to mum concentrations of GnRH exert depolarising actions on approximately 50% of GnRH neurones in males and females throughout the oestrous cycle.
Gene_expression (neurones) of GnRH
7) Confidence 0.68 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20041983 Disease Relevance 0.09 Pain Relevance 0.13
Electrophysiology was performed on GnRH neurons dissociated from young, middle-aged, or old female mice.
Gene_expression (neurons) of GnRH in neurons
8) Confidence 0.68 Published 2010 Journal Brain Res. Section Abstract Doc Link 20580637 Disease Relevance 0 Pain Relevance 0.12
Together with pharmacological experiments, these findings suggest that potassium and calcium channels are expressed in a differential manner within the GnRH phenotype.
Gene_expression (expressed) of GnRH associated with calcium channel
9) Confidence 0.68 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11157093 Disease Relevance 0 Pain Relevance 0.33
There was also an associated increase in the silver grain signal density in both male and female hpg mouse Kiss1 mRNA-positive neurons as measured by the cellular brightness of each neuron (P<0.05) (Fig. 5C).
Gene_expression (female) of hpg in neurons
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.93 Pain Relevance 0
This contrasts the lack of response of hpg AVPV kisspeptin neurons to E2 replacement.
Gene_expression (neurons) of hpg in neurons
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.61 Pain Relevance 0.07
In contrast, the hpg ARC kisspeptin neurons displayed robust increases in developmental Kiss1 expression in the absence of negative gonadal sex steroid feedback, suggestive of an intact upstream central mechanism driving puberty onset in both sexes.
Gene_expression (neurons) of hpg in gonadal associated with aids-related complex
12) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.33 Pain Relevance 0.05
Overwhelming evidence in mammalian species has shown that through its receptor (Kiss1R) located on GnRH neurons, the neuropeptide kisspeptin is a direct component of the reproductive control system and is a potent stimulator of GnRH release [3].
Gene_expression (neurons) of GnRH in neurons associated with neuropeptide
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0 Pain Relevance 0.14
These findings provide the first electrical and molecular characterization of the GnRH phenotype and demonstrate a novel pattern of late postnatal reorganization of native GABA(A) receptor gene expression and signalling in the GnRH neuronal population.
Gene_expression (expression) of GnRH in neuronal associated with gaba
14) Confidence 0.67 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.29
We examined GABAergic postsynaptic currents (PSCs) in green fluorescent protein-identified GnRH neurons from mice exposed to different steroid milieus in vivo.
Gene_expression (identified) of GnRH in neurons associated with gabaergic
15) Confidence 0.67 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15342358 Disease Relevance 0.29 Pain Relevance 0.33
To enable the measurement of intracellular calcium concentration ([Ca2+]i) in adult GnRH neurons in situ, we generated transgenic mice in which the genetically encodable calcium indicator ratiometric Pericam was expressed by approximately 95% of GnRH neurons.
Gene_expression (expressed) of GnRH in neurons associated with targeted disruption
16) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17251427 Disease Relevance 0.10 Pain Relevance 0.06
We and other research groups have exploited the hypogonadal (hpg) mouse [8], which cannot produce mature GnRH decapeptide due to a truncation in the GnRH gene, as a model to study the role of estrogen in male reproductive function [9,10].
Neg (cannot) Gene_expression (produce) of GnRH
17) Confidence 0.67 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.24 Pain Relevance 0
In rhesus monkeys and women, the steroid environment may also modulate in a different way the pattern of response of the HPA axis (and therefore the response of HPG axis including release of LH) elicited by acute stressors.
Gene_expression (axis) of HPG
18) Confidence 0.65 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.32 Pain Relevance 0
The expression of sstr2 by GnRH neurons was confirmed in the sstr2 knockout/LacZ knock-in mouse line.
Gene_expression (neurons) of GnRH in neurons associated with targeted disruption
19) Confidence 0.65 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.20 Pain Relevance 0.55
Together, these studies reveal somatostatin, acting through sstr2, to be one of the most potent inhibitors of electrical excitability of male and female GnRH neurons identified thus far.
Gene_expression (neurons) of GnRH in neurons associated with somatostatin
20) Confidence 0.65 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.17 Pain Relevance 0.42

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