INT107874

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.09
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc4) protein complex (Trpc4) transmembrane transport (Trpc4)
cytoplasm (Trpc4)
Anatomy Link Frequency
P48 1
neuronal 1
Trpc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 96 98.84 Very High Very High Very High
Pyramidal cell 44 95.36 Very High Very High Very High
Action potential 12 95.12 Very High Very High Very High
agonist 8 93.60 High High
Glutamate receptor 4 92.96 High High
member 8 2 90.00 High High
depression 4 89.44 High High
Nucleus accumbens 24 86.96 High High
halothane 12 62.48 Quite High
tetrodotoxin 4 61.76 Quite High
Disease Link Frequency Relevance Heat
Depression 4 89.44 High High
Urological Neuroanatomy 24 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If in fact mGluR stimulation activates TRPC4 or 5 channels producing a dADP, then in addition to the proposed presynaptic role this would provide a postsynaptic function for these channels in the corticolimbic system.


Positive_regulation (activates) of TRPC4
1) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.09 Pain Relevance 0.08
This dADP correlated with the presence of TRPC4 and 5 expression.
Positive_regulation (presence) of TRPC4
2) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.34
The transport of the TRPC5 channels into the presynaptic terminals and the up-regulation of TRPC4 and 5 protein levels in the HIP of P48 compared to P0 mice suggests that these channels may be involved in neuronal development.
Positive_regulation (up) of TRPC4 in neuronal associated with hippocampus
3) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.29
Immunoblots performed for TRPC4 and 5 protein in microdissections of HIP from post-natal day 0 (P0) and post-natal day 48 (P48) mice show that TRPC4 and 5 protein levels are higher at P48 compared to P0 (Figure 8C).
Positive_regulation (higher) of TRPC4 in P48 associated with hippocampus
4) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.14
PDGF treatment also upregulated TRPC6 expression and augmented CCE, elicited by passive depletion of Ca(2+) from the SR using cyclopiazonic acid.
Positive_regulation (augmented) of CCE
5) Confidence 0.01 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12529250 Disease Relevance 0 Pain Relevance 0.09
The resultant increase in CCE raises [Ca(2+)](cyt), facilitates return of Ca(2+) to the SR, and enhances PASMC growth.
Positive_regulation (increase) of CCE
6) Confidence 0.01 Published 2003 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12529250 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox