INT107875

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 49
Total Number 49
Disease Relevance 13.18
Pain Relevance 12.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
brain 5
neuronal 2
hypothalamus 2
sciatic nerve 2
myocardium 1
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 21 99.98 Very High Very High Very High
qutenza 65 99.84 Very High Very High Very High
Nerve growth factor 32 99.78 Very High Very High Very High
Potency 42 99.58 Very High Very High Very High
Sciatic nerve 30 99.32 Very High Very High Very High
cytokine 239 99.08 Very High Very High Very High
Spinal cord 23 98.76 Very High Very High Very High
Central nervous system 65 98.36 Very High Very High Very High
member 8 1 98.20 Very High Very High Very High
Inflammation 294 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 187 99.96 Very High Very High Very High
Death 144 99.68 Very High Very High Very High
Ocular Hypertension 90 99.60 Very High Very High Very High
Nociception 22 98.48 Very High Very High Very High
Stroke 291 97.72 Very High Very High Very High
INFLAMMATION 348 97.04 Very High Very High Very High
Neuropathic Pain 4 97.04 Very High Very High Very High
Nervous System Injury 2 95.72 Very High Very High Very High
Aids-related Complex 44 95.08 Very High Very High Very High
Reperfusion Injury 66 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK and STAT3 phosphorylation in sensory neurons during capsaicin-induced impairment and nerve growth factor treatment.
Phosphorylation (phosphorylation) of STAT3 in sensory neurons associated with nerve growth factor and qutenza
1) Confidence 0.80 Published 2005 Journal Pharmacology Section Title Doc Link 16141720 Disease Relevance 0.09 Pain Relevance 0.69
NGF increased STAT3 phosphorylation in DRG on day 1 and day 2 above the level observed in samples taken from rats at the same time points with a capsaicin treatment only.
Phosphorylation (phosphorylation) of STAT3 in DRG associated with qutenza and nerve growth factor
2) Confidence 0.79 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0 Pain Relevance 1.04
Posphorylated STAT3, which was almost non-detectable in the control sciatic nerve, clearly peaked at 6 h after the capsaicin treatment and decreased again during the following days to almost undetectable levels.
Phosphorylation (Posphorylated) of STAT3 in sciatic nerve associated with qutenza and sciatic nerve
3) Confidence 0.79 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0.06 Pain Relevance 0.98
Western blots were probed with polyclonal antibodies that specifically detect phosphorylated ERK 1/2 and STAT3.
Phosphorylation (phosphorylated) of STAT3
4) Confidence 0.79 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0.08 Pain Relevance 0.62
A basal level of phosphorylated STAT3 was present in DRGs of control animals, it remained at a high level up to 6 h after the capsaicin treatment, then markedly decreased and recovered on day 8 and day 16.
Phosphorylation (phosphorylated) of STAT3 associated with qutenza
5) Confidence 0.79 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0 Pain Relevance 1.13
FIT stimulation of H9C2 cells also caused a time-dependent phosphorylation of STAT3, Akt, and GSK-3beta, and this effect was abrogated by AG-490.
Phosphorylation (phosphorylation) of STAT3
6) Confidence 0.74 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.20 Pain Relevance 0.61
Morphine phosphorylated STAT3, Akt, and GSK-3beta, and phosphorylation was abrogated by AG-490.
Phosphorylation (phosphorylated) of STAT3 associated with morphine
7) Confidence 0.74 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.71
STAT3 phosphorylation was also dependent on phosphatidylinositol 3-kinase (PI3K) activation in both tissue and H9C2 cells.
Phosphorylation (phosphorylation) of STAT3
8) Confidence 0.74 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.14 Pain Relevance 0.56
Ligation of L5-L6 spinal nerves (SNL) evoked an accumulation of active, phosphorylated form of STAT3 in microglial cells of dorsal spinal cord mostly in projection areas of injured nerves.
Phosphorylation (phosphorylated) of STAT3 in spinal cord associated with spinal cord
9) Confidence 0.74 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.62 Pain Relevance 0.81
This was followed by signal transducer and activator of transcription 3 (STAT3) phosphorylation and induction of suppressor of cytokine signaling 3 (SOCS3).
Phosphorylation (phosphorylation) of signal transducer and activator of transcription 3 associated with cytokine
10) Confidence 0.73 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.13 Pain Relevance 0.25
This was followed by signal transducer and activator of transcription 3 (STAT3) phosphorylation and induction of suppressor of cytokine signaling 3 (SOCS3).
Phosphorylation (phosphorylation) of STAT3 associated with cytokine
11) Confidence 0.73 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.13 Pain Relevance 0.24
SR140333 less markedly attenuated the capsaicin-induced increase in phosphorylated STAT3: whereas in the sciatic nerve the difference was significant when the data at 3 h and 6 h were combined (p < 0.05), no such treatment effect of SR140333 was observed in the DRG.
Phosphorylation (phosphorylated) of STAT3 in sciatic nerve associated with qutenza and sciatic nerve
12) Confidence 0.65 Published 2006 Journal Pharmacology Section Abstract Doc Link 16788306 Disease Relevance 0 Pain Relevance 1.22
Morphine phosphorylated STAT3, Akt, and GSK-3beta, and phosphorylation was abrogated by AG-490.
Phosphorylation (phosphorylation) of STAT3 associated with morphine
13) Confidence 0.57 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.70
We could not prove involvement of the SAFE pathway [18], which is thought to interact with RISK signaling at reperfusion, as the IPC effluent failed to modulate the status of STAT3 phosphorylation (results not shown).
Phosphorylation (phosphorylation) of STAT3
14) Confidence 0.54 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.13 Pain Relevance 0.04
500, Cell Signaling), and phospho-Stat3 (1?
Phosphorylation (phospho) of Stat3
15) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.21 Pain Relevance 0
STAT-3 phosphorylation and activation in the hypothalamus is well known to play a pivotal role in the regulation of energy homeostasis.
Phosphorylation (phosphorylation) of STAT-3 in hypothalamus
16) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.44 Pain Relevance 0
This is in partial agreement with prior studies which have pinpointed the mechanism by which HN confers neuronal protection to the activation of tyrosine kinases and STAT-3 phosphorylation [14].
Phosphorylation (phosphorylation) of STAT-3 in neuronal
17) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.44 Pain Relevance 0
Since HN has been shown to work via STAT-3 activation, we examined the effect of acute HN ICV infusion on STAT-3 phosphorylation (pSTAT-3Tyr705) in the hypothalamus.
Phosphorylation (phosphorylation) of STAT-3 in hypothalamus
18) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
As presented in Fig. 3A, HN infusion resulted in a 10-fold increase in STAT-3 phosphorylation in hypothalamic tissues within an hour of ICV HN infusion (P<0.05).
Phosphorylation (phosphorylation) of STAT-3
19) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
The loss of the IPC effect in the aged myocardium was associated with reduced expression and phosphorylation of STAT3 [54,55].
Phosphorylation (phosphorylation) of STAT3 in myocardium
20) Confidence 0.47 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.08 Pain Relevance 0.23

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