INT107895

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.98
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
ganglia 2
peritoneal macrophages 2
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 99.32 Very High Very High Very High
TRP channel 67 96.40 Very High Very High Very High
qutenza 14 96.32 Very High Very High Very High
Nerve growth factor 1 90.24 High High
Inflammation 7 89.92 High High
agonist 2 85.20 High High
fifth nerve 2 85.16 High High
COX2 1 25.00 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 2 99.60 Very High Very High Very High
Targeted Disruption 4 97.60 Very High Very High Very High
Sprains And Strains 17 95.24 Very High Very High Very High
INFLAMMATION 7 89.92 High High
Ganglion Cysts 2 77.60 Quite High
Brain Injury 2 47.84 Quite Low
Loss Of Sense Of Smell 4 46.84 Quite Low
Apoptosis 2 33.36 Quite Low
Death 4 31.68 Quite Low
Necrosis 1 23.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The early recovery of TRPV2 is another interesting finding.
Positive_regulation (recovery) of Gene_expression (recovery) of TRPV2
1) Confidence 0.46 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.20
Immunohistochemical labeling detected TRPV1 and TRPV2 proteins in nodose ganglia.
Positive_regulation (detected) of Gene_expression (detected) of TRPV2 in ganglia
2) Confidence 0.37 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.15 Pain Relevance 0.34
Further, the cardiac-specific overexpression of TRPV2 caused a cardiomyopathy due to cellular Ca2+ overload in a transgenic mouse model.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TRPV2 associated with targeted disruption and coronary heart disease
3) Confidence 0.37 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.47 Pain Relevance 0
A high expression level of the VR-1 like protein (VRL-1) was observed in peritoneal macrophages, while the expression of VR-1 was not detected.
Positive_regulation (level) of Gene_expression (expression) of VRL-1 in peritoneal macrophages
4) Confidence 0.27 Published 2003 Journal Cell. Signal. Section Abstract Doc Link 12531428 Disease Relevance 0.36 Pain Relevance 1.06

General Comments

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