INT107898

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 27
Total Number 30
Disease Relevance 10.55
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
neurons 4
primary sensory neurons 4
ganglia 2
skeletal muscle 1
urothelial cells 1
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 364 100.00 Very High Very High Very High
qutenza 70 100.00 Very High Very High Very High
c fibre 8 100.00 Very High Very High Very High
dorsal root ganglion 25 99.84 Very High Very High Very High
Adelta 1 99.84 Very High Very High Very High
antagonist 51 99.32 Very High Very High Very High
Nerve growth factor 11 98.84 Very High Very High Very High
calcitonin gene related peptide 11 97.28 Very High Very High Very High
member 8 3 96.64 Very High Very High Very High
mu opioid receptor 4 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 102 99.86 Very High Very High Very High
Ganglion Cysts 116 99.84 Very High Very High Very High
Coronary Heart Disease 14 99.60 Very High Very High Very High
Sprains And Strains 103 97.88 Very High Very High Very High
Nociception 48 96.84 Very High Very High Very High
Brain Injury 8 94.00 High High
Loss Of Sense Of Smell 16 93.00 High High
Pressure And Volume Under Development 14 90.64 High High
INFLAMMATION 31 89.92 High High
Frailty 4 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The temperature-sensitive ion channel TRPV2 is endogenously expressed and functional in the primary sensory cell line F-11.
Gene_expression (expressed) of TRPV2
1) Confidence 0.76 Published 2005 Journal Cell. Physiol. Biochem. Section Title Doc Link 15665528 Disease Relevance 0.08 Pain Relevance 0.29
Our results indicate that F-11 cells express functional noxious heat-sensitive TRPV2 channels.
Gene_expression (express) of TRPV2
2) Confidence 0.76 Published 2005 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 15665528 Disease Relevance 0.07 Pain Relevance 0.24
These results suggest that TRPV2 is expressed predominantly in the NT-3-dependent subpopulation of DRG neurons throughout development and in adult mice.
Gene_expression (expressed) of TRPV2 in DRG associated with dorsal root ganglion
3) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 15561438 Disease Relevance 0.50 Pain Relevance 0.43
TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
Gene_expression (expressed) of TRPV2 in primary sensory neurons associated with qutenza
4) Confidence 0.75 Published 2005 Journal Neuroscience Section Title Doc Link 15561438 Disease Relevance 0.39 Pain Relevance 0.45
Although TRPV2 is expressed in medium- to large-sized dorsal root ganglion (DRG) neurons with myelinated fibers in adult rodents, little is known about the neurotrophin dependence of TRPV2-positive neurons in the developing and adult DRGs of mice.
Gene_expression (expressed) of TRPV2 in neurons associated with ganglion cysts, addiction and dorsal root ganglion
5) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 15561438 Disease Relevance 0.38 Pain Relevance 0.41
In the present study, using immunohistochemistry, we found that TRPV2 was first expressed in DRG neurons at embryonic day (E) 11.5, when neither TRPV1 nor TRPM8 was detected yet.
Gene_expression (expressed) of TRPV2 in neurons associated with dorsal root ganglion
6) Confidence 0.75 Published 2005 Journal Neuroscience Section Abstract Doc Link 15561438 Disease Relevance 0.44 Pain Relevance 0.46
The early recovery of TRPV2 expression observed in our study seems to support this hypothesis.
Gene_expression (expression) of TRPV2
7) Confidence 0.72 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.19
Moreover, expression of TRPV1 and TRPV2 recovered earlier.
Gene_expression (expression) of TRPV2
8) Confidence 0.72 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.73 Pain Relevance 0.10
When transgenic (Tg) mice expressing a TRPV2 mutant in muscle were crossed with mdx mice, the [Ca(2+)](i) increase in muscle fibers was reduced by dominant-negative inhibition of endogenous TRPV2.
Gene_expression (expressing) of TRPV2 in muscle fibers associated with targeted disruption
9) Confidence 0.67 Published 2009 Journal Hum. Mol. Genet. Section Abstract Doc Link 19050039 Disease Relevance 0.87 Pain Relevance 0.13
TRPV1, TRPV2, TRPV3 and TRPV4 mRNAs were expressed in spiral and vestibular ganglia, and TRPV2 and TRPV1 mRNAs were most predominant in control mice.
Gene_expression (expressed) of TRPV2 in ganglia
10) Confidence 0.65 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.08 Pain Relevance 0.23
These channels exhibit distinct thermal activation thresholds (>43 degrees C for TRPV1, >52 degrees C for TRPV2, >32-39 degrees C for TRPV3, >27-35 degrees C for TRPV4, <25-28 degrees C for TRPM8, and <17 degrees C for TRPA1) and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV2 in primary sensory neurons
11) Confidence 0.63 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467255 Disease Relevance 0.25 Pain Relevance 0.18
Moreover, in TRPV1(-/-) mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel.
Neg (not) Gene_expression (express) of TRPV2 in neurons
12) Confidence 0.63 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15254097 Disease Relevance 0.07 Pain Relevance 0.24
In the OE, TRPC1 and 6, TRPM3, 4, 5, 6, and 7, TRPV2 and 6, and TRPA1 have been shown to be expressed by RT-PCR [4].
Gene_expression (expressed) of TRPV2
13) Confidence 0.62 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.09 Pain Relevance 0.16
The early recovery of TRPV2 is another interesting finding.
Gene_expression (recovery) of TRPV2
14) Confidence 0.62 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.20
However, compared to the TRPC transcripts, TRPV2 and 4 mRNAs were expressed at much lower levels reaching only 3–10% of those of TRPC3 and TRPC4 (Fig. 2B and 3).
Gene_expression (expressed) of TRPV2
15) Confidence 0.62 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
Immunohistochemical labeling detected TRPV1 and TRPV2 proteins in nodose ganglia.
Gene_expression (detected) of TRPV2 in ganglia
16) Confidence 0.57 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14726308 Disease Relevance 0.15 Pain Relevance 0.34
These channels exhibit distinct thermal activation thresholds (>43 degrees C for TRPV1, >52 degrees C for TRPV2, > approximately 34-38 degrees C for TRPV3, > approximately 27-35 degrees C for TRPV4, < approximately 25-28 degrees C for TRPM8 and <17 degrees C for TRPA1), and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV2 in primary sensory neurons
17) Confidence 0.56 Published 2004 Journal J. Neurobiol. Section Abstract Doc Link 15362149 Disease Relevance 0.33 Pain Relevance 0.16
Expression of Trpv1 and Trpv2 is affected only in a subset of high-expressing neurons, while SP, CGRP, Accn3 and the mu opioid receptor (MOR) exhibit normal or increased expression in Runx1 knockouts [7,48].
Gene_expression (Expression) of Trpv2 in neurons associated with calcitonin gene related peptide and mu opioid receptor
18) Confidence 0.54 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.19 Pain Relevance 0.93
These channels exhibit distinct thermal activation thresholds (> 52 degrees C for TRPV2, > approximately 34-38 degrees C for TRPV3, > approximately 27-35 degrees C for TRPV4, < approximately 25-28 degrees C for TRPM8 and < 17 degrees C for TRPA1) and are expressed in primary sensory neurons as well as other tissues.
Gene_expression (expressed) of TRPV2 in primary sensory neurons
19) Confidence 0.53 Published 2004 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 15578965 Disease Relevance 0.72 Pain Relevance 0.80
In contrast to C57Bl/10, NOD and Balb/c mice showed a significant expression of TRPV2 and V4 in the heart and skeletal muscle.
Gene_expression (expression) of TRPV2 in heart
20) Confidence 0.48 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.58 Pain Relevance 0.08

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