INT1079

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 104
Total Number 108
Disease Relevance 23.52
Pain Relevance 30.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 6
muscle 5
cerebral cortex 4
substantia nigra 3
erythrocyte 3
Ache (Rattus norvegicus)
Ache - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 52 100.00 Very High Very High Very High
ketamine 5 100.00 Very High Very High Very High
cerebral cortex 174 99.98 Very High Very High Very High
gABA 10 99.96 Very High Very High Very High
Spinal cord 8 99.84 Very High Very High Very High
Sumatriptan 5 99.82 Very High Very High Very High
Substantia nigra 20 99.76 Very High Very High Very High
Action potential 2 99.76 Very High Very High Very High
qutenza 19 99.72 Very High Very High Very High
electroacupuncture 17 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cirrhosis 342 100.00 Very High Very High Very High
Stress 10 100.00 Very High Very High Very High
Hyperammonemia 72 99.76 Very High Very High Very High
Arrhythmias 2 Under Development 15 99.72 Very High Very High Very High
Ganglion Cysts 12 99.62 Very High Very High Very High
Disease 176 99.56 Very High Very High Very High
Diabetes Mellitus 222 99.34 Very High Very High Very High
Liver Failure 180 99.08 Very High Very High Very High
Hypoglycemia 117 99.00 Very High Very High Very High
Hepatic Encephalopathy 306 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ovariectomy enhances acetylcholinesterase activity but does not alter ganglioside content in cerebral cortex of female adult rats.
Positive_regulation (enhances) of acetylcholinesterase in cerebral cortex associated with cerebral cortex
1) Confidence 0.70 Published 2005 Journal Metab Brain Dis Section Title Doc Link 15918548 Disease Relevance 0.08 Pain Relevance 0.21
Results showed that rats subjected to ovariectomy presented a significant increase of AChE activity, but did not change the content and the profile of gangliosides in cerebral cortex when compared to sham or naive rats.
Positive_regulation (increase) of AChE in cerebral cortex associated with cerebral cortex
2) Confidence 0.70 Published 2005 Journal Metab Brain Dis Section Abstract Doc Link 15918548 Disease Relevance 0.09 Pain Relevance 0.24
On the contrary, acetylcholinesterase from synaptic membranes, although inhibited in vitro by ketamine, is activated in ketamine-anesthetised rats suggested that metabolic changes are at the basis of the effects observed in vivo.
Positive_regulation (activated) of acetylcholinesterase associated with ketamine
3) Confidence 0.70 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 7448016 Disease Relevance 0 Pain Relevance 0.35
Titration of AChE-active sites with O-ethyl-S2-diisopropyl methyl-phosphonothionate demonstrated that the increase in AChE activity associated with fibrillation is due to an increase in the number of AChE molecules present and not to an increase in the rate at which individual AChE molecules turn over acetylcholine.
Positive_regulation (increase) of AChE associated with arrhythmias 2 under development
4) Confidence 0.70 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6693937 Disease Relevance 0.25 Pain Relevance 0.32
Titration of AChE-active sites with O-ethyl-S2-diisopropyl methyl-phosphonothionate demonstrated that the increase in AChE activity associated with fibrillation is due to an increase in the number of AChE molecules present and not to an increase in the rate at which individual AChE molecules turn over acetylcholine.
Positive_regulation (increase) of AChE associated with arrhythmias 2 under development
5) Confidence 0.70 Published 1984 Journal J. Neurosci. Section Abstract Doc Link 6693937 Disease Relevance 0.26 Pain Relevance 0.33
However, MBT venom increased the acetylcholinesterase (AChE) activity (2-3 fold) in a concentration-dependent manner.
Positive_regulation (increased) of acetylcholinesterase
6) Confidence 0.70 Published 1999 Journal Indian J. Exp. Biol. Section Abstract Doc Link 10492617 Disease Relevance 0.09 Pain Relevance 0.09
Data obtained indicate that morphine administration during the light phase resulted in a significant increase (p less than 0.01) in AChE activity in the colon, with no significant effect on the stomach, duodenum or the ileum.
Positive_regulation (increase) of AChE in ileum associated with morphine
7) Confidence 0.69 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2730235 Disease Relevance 0 Pain Relevance 0.47
The results were as follows: (1) EA "Huantiao" could enhance AChE activity in the SDH and decrease [3H]-QNB binding sites; (2) Cap treating sciatice nerve could weaken AChE activity in the SDH and merease [3H]-QNB binding sites; (3) Cap treatment could inhibit or partially inhibit the actions of EA as above.
Positive_regulation (enhance) of AChE in SDH associated with qutenza, spinal dorsal horn and electroacupuncture
8) Confidence 0.69 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9387374 Disease Relevance 0 Pain Relevance 1.16
Significant increase (p less than 0.01) in AChE activity of the medulla oblongata was observed following morphine administration for 1 or 2 days.
Positive_regulation (increase) of AChE in medulla oblongata associated with medulla and morphine
9) Confidence 0.69 Published 1987 Journal Pharmacology Section Abstract Doc Link 3588657 Disease Relevance 0 Pain Relevance 1.09
Thus, the possibility that overall decreases in peripheral AChE activity in BDL rats may influence cerebrospinal fluid contents and trigger a central response, resulting in the accumulation of AChE in the brain, also deserves consideration.
Positive_regulation (accumulation) of AChE in brain
10) Confidence 0.68 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.20 Pain Relevance 0
We present evidence that in both, cirrhotic humans and rats, increased AChE activity is associated with a parallel increased in the major amphiphilic tetrameric molecular form.
Positive_regulation (increased) of AChE associated with cirrhosis
11) Confidence 0.68 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.25 Pain Relevance 0
The acute treatment with naloxone produced a significant decrease in Ca(2+),Mg(2+)-ATP-ase activity and an increase in AChE activity, only in synaptic plasma membranes of II type.
Positive_regulation (increase) of AChE in plasma associated with narcan
12) Confidence 0.68 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 10944006 Disease Relevance 0 Pain Relevance 0.59
The decrease of Ca(2+), Mg(2+)-ATP-ase enzymatic activity and the increased AChE activity are related to the interference of the drug on Ca(2+) homeostasis in synaptosoplasm, that leads to the activation of calcium-dependent processes, i.e. the extrusion of neurotransmitter.
Positive_regulation (increased) of AChE associated with neurotransmitter
13) Confidence 0.68 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 10944006 Disease Relevance 0 Pain Relevance 0.57
Treatment with permethrin alone caused significant increase in cortical and cerebellar AChE activity.
Positive_regulation (increase) of AChE
14) Confidence 0.68 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11248143 Disease Relevance 0 Pain Relevance 0.33
In these cultures, 86% of the cells with neuronal morphology were positive for intracellular acetylcholinesterase activity, 54% were positive for enkephalin-like immunoreactivity, and 4% were positive for substance P-like immunoreactivity.
Positive_regulation (positive) of acetylcholinesterase in neuronal associated with enkephalin and substance p
15) Confidence 0.68 Published 1986 Journal Brain Res. Section Abstract Doc Link 2418924 Disease Relevance 0.16 Pain Relevance 0.43
These changes in enzyme expression were accompanied by increases in the levels of AChE mRNA, suggesting the involvement of pretranslational regulatory mechanisms.
Positive_regulation (increases) of AChE
16) Confidence 0.68 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435507 Disease Relevance 0.08 Pain Relevance 0.27
D-Ala2-Met-enkephalinamide increased also acetylcholinesterase (AchE) activity but only in the hypothalamus.
Positive_regulation (increased) of AchE (A2M) in hypothalamus
17) Confidence 0.67 Published 1981 Journal Acta Physiol Pol Section Abstract Doc Link 7304195 Disease Relevance 0 Pain Relevance 0.40
D-Ala2-Met-enkephalinamide increased also acetylcholinesterase (AchE) activity but only in the hypothalamus.
Positive_regulation (increased) of acetylcholinesterase in hypothalamus
18) Confidence 0.67 Published 1981 Journal Acta Physiol Pol Section Abstract Doc Link 7304195 Disease Relevance 0 Pain Relevance 0.40
The onset of spontaneous contraction in rat primary muscle cultures coincides with an increase in acetylcholinesterase (AChE) activity.
Positive_regulation (increase) of acetylcholinesterase in muscle
19) Confidence 0.67 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16787423 Disease Relevance 0.07 Pain Relevance 0.12
The acetylcholinesterase activity was followed, as a variant of true cholinesterase, in three groups on non-selected patients: 10 of these were under local anesthesia with lidocaine, 12 were under general anesthesia with thiopenthal and halotane and 43 were under the same type of general anesthesia, that had also been given Pancuronium as a muscle relaxant.
Positive_regulation (followed) of acetylcholinesterase in muscle associated with anesthesia and lidocaine
20) Confidence 0.61 Published 1976 Journal Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir Section Abstract Doc Link 136679 Disease Relevance 0 Pain Relevance 0.51

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