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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L11) mitochondrion (BCL2L11) plasma membrane (BCL2L11)
cytoplasm (BCL2L11)
Anatomy Link Frequency
neuronal 2
T cells 2
BCL2L11 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 1 97.32 Very High Very High Very High
Morphine 10 96.64 Very High Very High Very High
antagonist 1 95.84 Very High Very High Very High
Analgesic 1 88.32 High High
Inflammation 1 87.12 High High
Multiple sclerosis 4 86.96 High High
Neuritis 1 86.16 High High
Disease Link Frequency Relevance Heat
Death 5 90.20 High High
INFLAMMATION 1 87.12 High High
Optic Neuritis 1 86.16 High High
Disease 2 84.96 Quite High
Paralysis 1 83.76 Quite High
Creutzfeldt Jakob Disease 4 83.28 Quite High
Recurrence 5 82.56 Quite High
Apoptosis 6 82.24 Quite High
Multiple Sclerosis 6 81.16 Quite High
Scrapie 1 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flupirtine normalizes the level of intracellular glutathione and increases the expression of the antiapoptotic Bcl-2 protein in neuronal cells exposed to prion protein.
Positive_regulation (increases) of Gene_expression (expression) of Bcl-2 protein in neuronal
1) Confidence 0.53 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532184 Disease Relevance 0.61 Pain Relevance 0.18
Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.
Positive_regulation (altering) of Gene_expression (expression) of Bim in T cells
2) Confidence 0.49 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.18 Pain Relevance 0.28
ROS-amplified JNK induced cytochrome c release and caspase-9/3 activation through enhancement of expression of the proapoptotic protein Bim and reduction of expression of the antiapoptotic protein Bcl-2.
Positive_regulation (enhancement) of Gene_expression (expression) of Bim
3) Confidence 0.49 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.44 Pain Relevance 0.77

General Comments

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