INT107904

Context Info Confidence 0.53 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.22 Pain Relevance 1.24

cytosol (BCL2L11) mitochondrion (BCL2L11) plasma membrane (BCL2L11) cytoplasm (BCL2L11)

Anatomy Link Frequency neuronal 2 T cells 2 BCL2L11 (Homo sapiens)

Pain Link Frequency Relevance Heat nMDA receptor 1 97.32 Morphine 10 96.64 antagonist 1 95.84 Analgesic 1 88.32 Inflammation 1 87.12 Multiple sclerosis 4 86.96 Neuritis 1 86.16

Disease Link Frequency Relevance Heat Death 5 90.20 INFLAMMATION 1 87.12 Optic Neuritis 1 86.16 Disease 2 84.96 Paralysis 1 83.76 Creutzfeldt Jakob Disease 4 83.28 Recurrence 5 82.56 Apoptosis 6 82.24 Multiple Sclerosis 6 81.16 Scrapie 1 76.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Flupirtine normalizes the level of intracellular glutathione and increases the expression of the antiapoptotic Bcl-2 protein in neuronal cells exposed to prion protein.

Positive_regulation (increases) of Gene_expression (expression) of Bcl-2 protein in neuronal

1) Confidence 0.53 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532184 Disease Relevance 0.61 Pain Relevance 0.18

Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.

Positive_regulation (altering) of Gene_expression (expression) of Bim in T cells

2) Confidence 0.49 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.18 Pain Relevance 0.28

ROS-amplified JNK induced cytochrome c release and caspase-9/3 activation through enhancement of expression of the proapoptotic protein Bim and reduction of expression of the antiapoptotic protein Bcl-2.

Positive_regulation (enhancement) of Gene_expression (expression) of Bim

3) Confidence 0.49 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.44 Pain Relevance 0.77

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