INT107905

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.58
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L11) mitochondrion (BCL2L11) plasma membrane (BCL2L11)
cytoplasm (BCL2L11)
Anatomy Link Frequency
neuronal 1
T cells 1
BCL2L11 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 99.96 Very High Very High Very High
nMDA receptor 1 96.76 Very High Very High Very High
Morphine 10 96.04 Very High Very High Very High
antagonist 5 95.28 Very High Very High Very High
Analgesic 1 87.76 High High
Multiple sclerosis 4 86.96 High High
Inflammation 3 86.76 High High
Neuritis 1 85.80 High High
Opioid 2 83.20 Quite High
metalloproteinase 68 75.56 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 129 100.00 Very High Very High Very High
Death 29 99.64 Very High Very High Very High
Hemiplegia 29 97.68 Very High Very High Very High
Necrosis 4 97.28 Very High Very High Very High
Cancer 286 96.92 Very High Very High Very High
Lung Cancer 272 95.08 Very High Very High Very High
Teratocarcinoma 2 94.16 High High
Contagious Ecthyma 1 92.24 High High
Epstein-barr Virus 38 91.88 High High
Retinoblastoma 2 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.
Gene_expression (expression) of Bim in T cells
1) Confidence 0.75 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.17 Pain Relevance 0.28
ROS-amplified JNK induced cytochrome c release and caspase-9/3 activation through enhancement of expression of the proapoptotic protein Bim and reduction of expression of the antiapoptotic protein Bcl-2.
Gene_expression (expression) of Bim
2) Confidence 0.75 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292871 Disease Relevance 0.43 Pain Relevance 0.77
The two others map to the Bam H1 A region.
Gene_expression (region) of Bam
3) Confidence 0.65 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.72 Pain Relevance 0
Flupirtine normalizes the level of intracellular glutathione and increases the expression of the antiapoptotic Bcl-2 protein in neuronal cells exposed to prion protein.
Gene_expression (expression) of Bcl-2 protein in neuronal
4) Confidence 0.59 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532184 Disease Relevance 0.61 Pain Relevance 0.18
Bim/Bod Bcl-2 like11 (apoptosis facilitator)
Gene_expression (/) of Bim associated with apoptosis
5) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.81 Pain Relevance 0.34
Bim/Bod Bcl-2 like11 (apoptosis facilitator)
Gene_expression (like11) of Bim associated with apoptosis
6) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.81 Pain Relevance 0.34
Historically, therapists have focused on a bimanual approach (BIM training) in the management of motor dysfunction in children with hemiplegia[28].
Gene_expression (training) of BIM associated with hemiplegia
7) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2832893 Disease Relevance 0.16 Pain Relevance 0
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Gene_expression (expression) of Bim associated with apoptosis
8) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.53 Pain Relevance 0
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Gene_expression (expression) of Bim associated with apoptosis
9) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.34 Pain Relevance 0

General Comments

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