INT107910

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.88
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tnfrsf11b, Tnfsf11) cell differentiation (Tnfsf11) intracellular (Tnfsf11)
extracellular matrix organization (Tnfrsf11b) cytoplasm (Tnfsf11) signal transduction (Tnfrsf11b)
Anatomy Link Frequency
osteoclast 1
Tnfrsf11b (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 93 89.48 High High
Inflammation 180 88.56 High High
withdrawal 4 79.28 Quite High
metalloproteinase 8 76.08 Quite High
Pain 2 71.84 Quite High
cytokine 106 50.56 Quite High
Arthritis 19 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
spinal inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteolysis 5 98.08 Very High Very High Very High
Metastasis 11 97.24 Very High Very High Very High
Hypercalcemia 32 96.80 Very High Very High Very High
Reprotox - General 1 10 95.52 Very High Very High Very High
Cancer 24 91.44 High High
Rheumatoid Arthritis 93 89.48 High High
Necrosis 14 89.36 High High
INFLAMMATION 189 88.56 High High
Postmenopausal Osteoporosis 12 83.04 Quite High
Osteoporosis 187 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another factor, osteoprotegerin, is a soluble decoy receptor for RANKL and inhibits RANKL-induced osteoclastogenesis.
osteoprotegerin Binding (receptor) of RANKL
1) Confidence 0.30 Published 2002 Journal Drugs Today Section Abstract Doc Link 12532187 Disease Relevance 2.14 Pain Relevance 0.11
Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, functions as a soluble decoy receptor to RANKL and competes with RANK for RANKL binding.
OPG Binding (binding) of RANKL
2) Confidence 0.20 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.79 Pain Relevance 0.07
Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, functions as a soluble decoy receptor to RANKL and competes with RANK for RANKL binding.
OPG Binding (receptor) of RANKL
3) Confidence 0.20 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.78 Pain Relevance 0.07
Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, functions as a soluble decoy receptor to RANKL and competes with RANK for RANKL binding.
Osteoprotegerin Binding (binding) of RANKL
4) Confidence 0.05 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.80 Pain Relevance 0.10
Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, functions as a soluble decoy receptor to RANKL and competes with RANK for RANKL binding.
Osteoprotegerin Binding (receptor) of RANKL
5) Confidence 0.05 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.78 Pain Relevance 0.09
A further level of regulation is provided by osteoprotegerin, which acts as a soluble decoy receptor of RANKL, and thus is an effective inhibitor of RANK signalling and osteoclast differentiation [145,146].
osteoprotegerin Binding (receptor) of RANKL in osteoclast
6) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.58 Pain Relevance 0.26

General Comments

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