INT107915

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.47
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brains 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 36 100.00 Very High Very High Very High
cINOD 18 100.00 Very High Very High Very High
Inflammation 33 87.36 High High
Hippocampus 6 55.76 Quite High
cytokine 7 41.84 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 100.00 Very High Very High Very High
INFLAMMATION 39 100.00 Very High Very High Very High
Alzheimer's Dementia 36 100.00 Very High Very High Very High
Immunization 5 99.96 Very High Very High Very High
Targeted Disruption 25 99.36 Very High Very High Very High
Amyloid Plaque 11 92.56 High High
Neurodegenerative Disease 4 88.00 High High
Dementia 8 86.08 High High
Death 2 83.28 Quite High
Apoptosis 2 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we will focus on the more relevant therapeutical strategies currently used, namely those involving antioxidants, drugs for neurotransmission improvement, hormonal replacement, gamma- and beta- secretase inhibitors, Abeta clearance agents (Abeta immunization, disruption of Abeta fibrils, modulation of the cholesterol-mediated Abeta transport), non-steroidal anti-inflammatory drugs (NSAIDs), microtubules stabilizing drugs and kinase inhibitors.
Regulation (modulation) of Negative_regulation (disruption) of Abeta associated with inflammation, immunization, cinod and abeta
1) Confidence 0.45 Published 2005 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 16101556 Disease Relevance 0.94 Pain Relevance 0.48
The dysregulation in the metabolism of beta-amyloid precursor protein and consequent deposition of amyloid-beta (Abeta) has been envisaged as crucial for the development of neurodegeneration in Alzheimer's disease (AD).
Regulation (dysregulation) of Negative_regulation (deposition) of amyloid-beta associated with alzheimer's dementia, disease and abeta
2) Confidence 0.45 Published 2003 Journal Drugs Aging Section Abstract Doc Link 12534311 Disease Relevance 0.64 Pain Relevance 0.15
The dysregulation in the metabolism of beta-amyloid precursor protein and consequent deposition of amyloid-beta (Abeta) has been envisaged as crucial for the development of neurodegeneration in Alzheimer's disease (AD).
Regulation (dysregulation) of Negative_regulation (deposition) of Abeta associated with alzheimer's dementia, disease and abeta
3) Confidence 0.45 Published 2003 Journal Drugs Aging Section Abstract Doc Link 12534311 Disease Relevance 0.65 Pain Relevance 0.15
Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Regulation (Effects) of Negative_regulation (deposition) of Abeta associated with targeted disruption, inflammation, cinod and abeta
4) Confidence 0.23 Published 2009 Journal Brain Res. Section Title Doc Link 19666013 Disease Relevance 1.10 Pain Relevance 0.96
Because the deposition of beta-amyloid protein is a consistent pathological hallmark of brains affected by AD, the inhibition of A-beta generation, prevention of A-beta fibril formation, destabilization of pre-formed A-beta would be an attractive therapeutic strategy for the treatment of AD.
Regulation (affected) of Negative_regulation (prevention) of A-beta in brains associated with alzheimer's dementia and disease
5) Confidence 0.23 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 1.14 Pain Relevance 0
Age-related effects of partial BACE1 reduction on APP processing and A?
Regulation (effects) of Negative_regulation (reduction) of APP
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0 Pain Relevance 0.03

General Comments

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