INT107916

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 1.00
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 114
Total Number 120
Disease Relevance 66.71
Pain Relevance 12.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 58
Notch 4
plaques 2
astrocytes 2
plasma 1
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 53 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
metalloproteinase 363 99.90 Very High Very High Very High
Central nervous system 328 99.88 Very High Very High Very High
Inflammation 974 99.48 Very High Very High Very High
cINOD 633 99.24 Very High Very High Very High
cytokine 364 96.08 Very High Very High Very High
Spinal cord 137 94.50 High High
agonist 84 91.60 High High
Glutamate receptor 17 89.52 High High
Disease Link Frequency Relevance Heat
Disease 5424 100.00 Very High Very High Very High
Alzheimer's Dementia 1688 100.00 Very High Very High Very High
Amyloid Plaque 602 99.60 Very High Very High Very High
Targeted Disruption 1964 99.48 Very High Very High Very High
INFLAMMATION 1269 99.48 Very High Very High Very High
Toxicity 195 97.88 Very High Very High Very High
Disease Progression 79 97.72 Very High Very High Very High
Congenital Anomalies 151 97.48 Very High Very High Very High
Cognitive Disorder 914 97.36 Very High Very High Very High
Drug Induced Neurotoxicity 92 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile.
Protein_catabolism (cleavage) of APP in Notch associated with inflammation, alzheimer's dementia and cinod
1) Confidence 1.00 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.35 Pain Relevance 0.45
Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase.
Protein_catabolism (cleaved) of amyloid precursor protein associated with alzheimer's dementia and abeta
2) Confidence 0.99 Published 2005 Journal Drugs Aging Section Abstract Doc Link 16506440 Disease Relevance 0.88 Pain Relevance 0.18
Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase.
Protein_catabolism (cleaved) of APP associated with alzheimer's dementia and abeta
3) Confidence 0.99 Published 2005 Journal Drugs Aging Section Abstract Doc Link 16506440 Disease Relevance 0.87 Pain Relevance 0.18
In the predominant pathway, APP is first cleaved by the ?
Protein_catabolism (cleaved) of APP
4) Confidence 0.95 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.10 Pain Relevance 0
The authors came to the conclusion that caspase cleavage of APP does not play a critical role in the generation of AD-related abnormalities in these transgenic mice, and that therefore the D664 cleavage site of APP would not be a suitable target for the development of therapeutic interventions.
Protein_catabolism (cleavage) of APP in cleavage associated with targeted disruption, congenital anomalies and disease
5) Confidence 0.93 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 1.23 Pain Relevance 0
Alternatively, BACE1 cleavage of APP leading to AICD-mediated gene transcription may be important for cognitive function [67].
Protein_catabolism (cleavage) of APP in cleavage associated with cognitive disorder
6) Confidence 0.89 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.43 Pain Relevance 0.09
APP is first cleaved by the ?
Protein_catabolism (cleaved) of APP
7) Confidence 0.89 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 1.20 Pain Relevance 0
Recent studies indicating that some nonsteroidal anti-inflammatory drugs (NSAIDs) selectively modulate gamma-secretase cleavage of amyloid precursor protein (APP) while sparing Notch processing have generated interest in discovery of novel gamma-secretase modulators with the "NSAID-like" efficacy profile.
Protein_catabolism (cleavage) of amyloid precursor protein in Notch associated with inflammation, alzheimer's dementia and cinod
8) Confidence 0.89 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.35 Pain Relevance 0.45
The Swedish mutation enhances the cleavage of APP by BACE1.
Protein_catabolism (cleavage) of APP in cleavage
9) Confidence 0.88 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.22 Pain Relevance 0
While the BACE1-mediated cleavage of APP is predominantly regarded as a negative process, Ma and colleagues reported the facilitation of learning, memory and synaptic plasticity by this cleavage event [68].
Protein_catabolism (cleavage) of APP in cleavage
10) Confidence 0.88 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.20 Pain Relevance 0
-secretase-mediated proteolysis of APP C-terminal fragments C99 and C83.
Protein_catabolism (proteolysis) of APP in C83
11) Confidence 0.88 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.14 Pain Relevance 0.16
In cultured cells, statins affect cleavage of the amyloid precursor protein via the ROCK kinase.
Protein_catabolism (cleavage) of amyloid precursor protein in cleavage associated with alzheimer's dementia
12) Confidence 0.88 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC543463 Disease Relevance 0.27 Pain Relevance 0.03
After the cessation of mGluR signaling, APP levels presumably drop due to degradation, which appears more robust in WT than KO cells.


Protein_catabolism (degradation) of APP associated with targeted disruption
13) Confidence 0.87 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.83 Pain Relevance 0
-secretase, the enzyme responsible for the second cleavage of APP, is another method to reduce the production of A?.
Protein_catabolism (cleavage) of APP in cleavage
14) Confidence 0.87 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.33 Pain Relevance 0.18
-secretase cleavage of APP in human astrocytes and thereby increase production of A?
Protein_catabolism (cleavage) of APP in astrocytes
15) Confidence 0.85 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.63 Pain Relevance 0.25
degradation, we mixed conditioned media from the APP-overexpressing cell line with concentrated media from cells expressing empty vector, wild-type NEP, or sNEP.
Protein_catabolism (degradation) of APP
16) Confidence 0.85 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
1 canstimulate the synthesis and cleavage of glial APP, caution has to be exerted when extrapolating this conclusion to an in vivo context: the mice used in the present study produce TGF-?
Protein_catabolism (cleavage) of APP in cleavage
17) Confidence 0.84 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.06 Pain Relevance 0
-secretase-dependent cleavage of APP generates the A?
Protein_catabolism (cleavage) of APP in cleavage
18) Confidence 0.83 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.39 Pain Relevance 0.37
-cleavage of APP or Notch [78].
Protein_catabolism (cleavage) of APP in Notch
19) Confidence 0.80 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0
-secretase cleavage by an elusive mechanism that modulates the proteolysis of APP to selectively enhance the generation of highly amyloidogenic A?
Protein_catabolism (proteolysis) of APP in cleavage
20) Confidence 0.80 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.64 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox