INT107923

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 2.73
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 2
vagina 2
plaques 2
placentas 2
vascular endothelium 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Opioid 3 98.68 Very High Very High Very High
cytokine 12 97.56 Very High Very High Very High
antagonist 15 96.56 Very High Very High Very High
Angina 7 94.00 High High
COX2 4 92.20 High High
Tetrahydrobiopterin 2 87.44 High High
Inflammation 38 86.80 High High
ischemia 4 82.60 Quite High
Disease Link Frequency Relevance Heat
Pre-eclampsia 66 99.84 Very High Very High Very High
Hypertension 99 97.12 Very High Very High Very High
Acute Coronary Syndrome 6 95.72 Very High Very High Very High
INFLAMMATION 40 95.32 Very High Very High Very High
Cv General 3 Under Development 7 94.00 High High
Rupture 2 85.12 High High
Coronary Artery Disease 3 82.60 Quite High
Syndrome 9 82.12 Quite High
Increased Venous Pressure Under Development 64 78.28 Quite High
Stress 27 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of eNOS expression in HCAEC cell line treated with opioids and proinflammatory cytokines.
Regulation (Regulation) of Gene_expression (expression) of eNOS associated with narcan, opioid and cytokine
1) Confidence 0.61 Published 2006 Journal Kardiol Pol Section Title Doc Link 16502366 Disease Relevance 0 Pain Relevance 0.20
These results indicate that opioids (basal release) do not affect eNOS expression in normal in vitro culture conditions but might do so upon stress stimuli.


Neg (not) Regulation (affect) of Gene_expression (expression) of eNOS
2) Confidence 0.24 Published 2006 Journal Kardiol Pol Section Body Doc Link 16502366 Disease Relevance 0 Pain Relevance 0
RESULTS: Opioid treatment altered eNOS expression; however, none of the changes reached a statistically significant level.
Regulation (altered) of Gene_expression (expression) of eNOS
3) Confidence 0.24 Published 2006 Journal Kardiol Pol Section Body Doc Link 16502366 Disease Relevance 0.07 Pain Relevance 0
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Regulation (effect) of Gene_expression (expression) of endothelial NO synthase in endothelial cells associated with hypertension and cinod
4) Confidence 0.23 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.70
It was also found that estrogen treatment down-regulates eNOS and nNOS expression in the rabbit vagina [41].
Regulation (regulates) of Gene_expression (expression) of eNOS in vagina
5) Confidence 0.23 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2907491 Disease Relevance 0 Pain Relevance 0.17
vascular endothelium and named eNOS and the other is present in the
Regulation (present) of Gene_expression (present) of eNOS in vascular endothelium
6) Confidence 0.21 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.14 Pain Relevance 0.13
The nNOS and iNOS are predominantly soluble enzymes whereas eNOS
Regulation (soluble) of Gene_expression (enzymes) of eNOS
7) Confidence 0.21 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.16 Pain Relevance 0.16
The evaluation of the local expression of eNOS in preeclampsia has yielded discordant results.
Regulation (evaluation) of Gene_expression (expression) of eNOS associated with pre-eclampsia
8) Confidence 0.20 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.26 Pain Relevance 0
Schiessl on the other hand, found no differences in immunohistochemical expression of eNOS in the syncytiotrophoblast and extravillous trophoblast of placentas of normal controls and preeclamptic mothers, although placentas with IUGR show a decreased immunoreactivity and eNOS protein content, as estimated by Western blotting[119].
Neg (no) Regulation (differences) of Gene_expression (expression) of eNOS in placentas
9) Confidence 0.20 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.29 Pain Relevance 0
Pathological increases in cellular NO levels due to an increase in iNOS expression or overactivation of eNOS and nNOS result in the formation of peroxynitrite (ONOO-) radical [67].
Regulation (overactivation) of Gene_expression (expression) of eNOS
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.13 Pain Relevance 0
Total RNA was extracted from the 30 plaques and the cDNA was amplified in order to determine endothelial nitric oxide synthase (eNOS) gene expression.
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (expression) of eNOS in plaques
11) Confidence 0.13 Published 2005 Journal Eur J Histochem Section Abstract Doc Link 15823793 Disease Relevance 1.28 Pain Relevance 0.37
CONCLUSION: Patients taking aspirin before UA showed a lower systemic inflammatory response and higher eNOS protein expression in their neutrophils


Regulation (response) of Gene_expression (expression) of eNOS in neutrophils
12) Confidence 0.04 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12534448 Disease Relevance 0.06 Pain Relevance 0

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