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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.86
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 8 99.14 Very High Very High Very High
Pain 17 98.48 Very High Very High Very High
cytokine 11 94.52 High High
Inflammation 72 93.20 High High
dorsal root ganglion 46 90.60 High High
headache 1 88.80 High High
Hyperalgesia 24 50.00 Quite Low
Thermal hyperalgesia 6 41.68 Quite Low
abdominal pain 1 40.56 Quite Low
withdrawal 8 37.72 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 34 99.96 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 3 99.38 Very High Very High Very High
Headache 9 99.14 Very High Very High Very High
Pain 20 98.48 Very High Very High Very High
Fever 2 98.12 Very High Very High Very High
Syndrome 4 95.28 Very High Very High Very High
Necrosis 14 93.24 High High
INFLAMMATION 82 93.20 High High
Cancer 14 92.88 High High
Convalescence 17 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed photographs presented in cited publications [42,43] clearly show both cytoplasmic and membrane-bound localization of TNFR1 and TNFR2.
Localization (localization) of TNFR1
1) Confidence 0.70 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.29 Pain Relevance 0.03
Forward and reverse primers were designed for the TNFR1 and TNFR2 mRNA using Primer Express software (Applied Biosystems, Foster City, CA, USA).
Localization (using) of TNFR1
2) Confidence 0.63 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.18 Pain Relevance 0.09
TRAPS is caused by mutations of the TNFRSF1A gene localized at 12p13.
Localization (localized) of TNFRSF1A gene associated with tumor necrosis factor receptor-associated periodic syndrome
3) Confidence 0.16 Published 2005 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 15859396 Disease Relevance 1.49 Pain Relevance 0.17
In class 2 (CLU, HMOX1, IL10RB, IL1R1, IL1R2, SERPINB2, SOD2, TIMP1, TNFRSF1A), the abundance of the transcripts significantly decreased but did not return to control values (Fig 2, 3).
Localization (decreased) of TNFRSF1A
4) Confidence 0.04 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.62 Pain Relevance 0
If TNF-alpha plays a role in migraine physiopathology, migraine patients may lack sufficient antagonistic sTNF-RI to neutralize hyperalgesic TNF-alpha during a migraine attack.
Localization (neutralize) of sTNF-RI associated with hyperalgesia and migraine
5) Confidence 0.01 Published 2003 Journal Cephalalgia Section Abstract Doc Link 12534582 Disease Relevance 1.27 Pain Relevance 1.08

General Comments

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