INT107928

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 3.76
Pain Relevance 16.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a6)
Anatomy Link Frequency
neurons 7
dorsal horn 6
CNS 3
brain 2
spinal 2
Slc17a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 117 100.00 Very High Very High Very High
Glutamate 99 100.00 Very High Very High Very High
Enkephalin 53 100.00 Very High Very High Very High
opioid receptor 32 100.00 Very High Very High Very High
Dopamine 19 100.00 Very High Very High Very High
Substantia nigra 15 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
Dorsal horn 17 99.98 Very High Very High Very High
Pyramidal cell 34 99.96 Very High Very High Very High
Dorsal horn neuron 11 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 432 99.84 Very High Very High Very High
Nociception 13 99.08 Very High Very High Very High
Ganglion Cysts 2 98.70 Very High Very High Very High
Increased Venous Pressure Under Development 13 97.80 Very High Very High Very High
Anxiety Disorder 3 94.04 High High
Shock 4 89.08 High High
Generalized Anxiety Disorder 2 87.60 High High
Disseminated Intravascular Coagulation 5 81.96 Quite High
Vibrio Infection 3 67.36 Quite High
Parkinson's Disease 2 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of the mu-opioid receptor splice variant MOR1C and the vesicular glutamate transporter 2 (VGLUT2) in rat central nervous system.
Gene_expression (Coexpression) of VGLUT2 in central nervous system associated with glutamate, central nervous system and opioid receptor
1) Confidence 0.76 Published 2008 Journal J. Comp. Neurol. Section Title Doc Link 18381590 Disease Relevance 0 Pain Relevance 0.97
The purpose of the present study was to examine whether a particular mu-opioid receptor (MOR) splice-variant, MOR(1C), is expressed in rat central nervous system (CNS) by terminals expressing the vesicular glutamate transporter2 (VGLUT2), a marker of glutamatergic neurons.
Gene_expression (expressing) of VGLUT2 in CNS associated with glutamate, central nervous system and opioid receptor
2) Confidence 0.76 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18381590 Disease Relevance 0 Pain Relevance 0.81
Thus, it appears that coexpression of MOR(1C) and VGLUT2 is common in the rat CNS.
Gene_expression (coexpression) of VGLUT2 in CNS associated with central nervous system and opioid receptor
3) Confidence 0.76 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18381590 Disease Relevance 0 Pain Relevance 1.00
Second, this part roughly corresponds to "area 1" defined by Okada et al. [52] in which small neurons expressing VGLUT2 and GAD67 are localized, allowing comparison with a limited and defined group of cNTS neurons.
Gene_expression (expressing) of VGLUT2 in neurons
4) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.08 Pain Relevance 0.13
We examined immunohistochemically whether the vesicular glutamate transporters (VGluTs), VGluT1 and VGluT2, might be expressed in synaptic terminals of nociceptive primary afferent fibers within laminae I and II of the medullary and spinal dorsal horns of the rat.
Gene_expression (expressed) of VGluT2 in dorsal horns associated with nociception, glutamate and primary afferent fibers
5) Confidence 0.72 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.17 Pain Relevance 0.23
Thus, the results indicated in laminae I and II of the medullary and spinal dorsal horns that both VGluT1 and VGluT2 were expressed in axon terminals of primary afferent fibers, including SP-containing nociceptive fibers and that VGluT in unmyelinated primary afferent fibers terminating in lamina II was primarily VGluT2.
Gene_expression (expressed) of VGluT2 in dorsal horns associated with nociception, primary afferent fibers, unmyelinated and substance p
6) Confidence 0.72 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.17 Pain Relevance 0.53
Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.
Gene_expression (Expression) of VGluT2 in spinal associated with nociception, pain, glutamate and primary afferent fibers
7) Confidence 0.72 Published 2003 Journal J. Comp. Neurol. Section Title Doc Link 12541308 Disease Relevance 0.19 Pain Relevance 0.44
Morphology and electrophysiological properties of hamster spinal dorsal horn neurons that express VGLUT2 and enkephalin.
Gene_expression (express) of VGLUT2 in dorsal horn associated with enkephalin and dorsal horn neuron
8) Confidence 0.72 Published 2007 Journal J. Comp. Neurol. Section Title Doc Link 17299755 Disease Relevance 0.18 Pain Relevance 0.90
However, VGLUT2 expression was significantly higher in neurons with depolarized resting membrane potential.
Gene_expression (expression) of VGLUT2 in neurons
9) Confidence 0.72 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17299755 Disease Relevance 0.24 Pain Relevance 0.81
The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn.
Gene_expression (expression) of VGLUT2 in spinal cord associated with glutamate, dorsal horn, enkephalin and spinal cord
10) Confidence 0.67 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12534965 Disease Relevance 0 Pain Relevance 0.71
This co-localization is most apparent in the posteroventral part of the MEA, where 70% of ENKergic cells expressed VGLUT2.
Gene_expression (expressed) of VGLUT2 in MEA
11) Confidence 0.64 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.37
VGLUT1 and -2 expression is mostly segregated to specific divisions of the amygdale, with VGLUT2 being expressed only in the MEA, the anterior cortical nucleus (COAa), and the anterior basomedial nucleus (BMAa), whereas VGLUT1 is expressed in all other divisions of the amygdala.
Gene_expression (expressed) of VGLUT2 in anterior associated with amygdala
12) Confidence 0.64 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.40
The majority of neurons expressing VGLUT2 and/or ENK had axons with dense local terminations or projections consistent with propriospinal functions.
Gene_expression (expressing) of VGLUT2 in neurons associated with enkephalin
13) Confidence 0.63 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17299755 Disease Relevance 0.28 Pain Relevance 0.93
We also provide immunohistochemical evidence that thalamic lesions markedly decreased striatal expression of the vesicular glutamate transporter vGluT2, confirming the association of this transporter with the thalamic projections to the basal ganglia.
Gene_expression (expression) of vGluT2 in basal ganglia associated with glutamate
14) Confidence 0.58 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14748558 Disease Relevance 0.06 Pain Relevance 0.38
Two vesicular glutamate transporters, VGLUT1 and VGLUT2, have recently been identified, and it has been reported that they are expressed by largely nonoverlapping populations of glutamatergic neurons in the brain.
Gene_expression (expressed) of VGLUT2 in brain associated with glutamate
15) Confidence 0.58 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534965 Disease Relevance 0 Pain Relevance 0.39
Ventral motor neurons were devoid of cGMP-IR. cGMP-IR was observed in GABAergic, and glutamatergic terminals in all gray matter laminae. cGMP-IR was abundantly colocalized with anti-vesicular glutamate transporter 2 (vGLUT2), however not with the anti-vesicular glutamate transporter 1 (vGLUT1), suggesting a functional difference between structures expressing vGLUT1 or vGLUT2. cGMP-IR did not colocalize with substance P- or calcitonin-gene related peptide-IR structures, however did partially colocalize with isolectin B4 in the dorsal horn. cGMP-IR in cholinergic structures was observed in dorsal root fibers entering the spinal cord, occasionally in laminae 1-3, in laminae 8 and 9 in isolated boutons and in the C-type terminals, and in small cells and varicosities in lamina 10.
Gene_expression (expressing) of vGLUT2 in dorsal horn associated with glutamate, gabaergic, dorsal horn, increased venous pressure under development, spinal cord and substance p
16) Confidence 0.57 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16621445 Disease Relevance 0.08 Pain Relevance 0.52
Therefore, we used immunohistochemistry and confocal microscopy to investigate expression of the VGLUT2 vesicular glutamate transporter, an isoform reported in nonprimary afferent spinal synapses, and ENK in electrophysiologically identified neurons of hamster spinal dorsal horn.
Spec (investigate) Gene_expression (expression) of VGLUT2 in spinal associated with glutamate, spinal dorsal horn and enkephalin
17) Confidence 0.56 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17299755 Disease Relevance 0.21 Pain Relevance 0.83
Increased VGLUT2 expression in these neurons might constitute a marker for antipsychotic activity and subcortical glutamate neurotransmission might be a possible novel target for future generation antipsychotics.
Gene_expression (expression) of VGLUT2 in neurons associated with glutamate
18) Confidence 0.53 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18155072 Disease Relevance 0.09 Pain Relevance 0.34
Antipsychotics increase vesicular glutamate transporter 2 (VGLUT2) expression in thalamolimbic pathways.
Gene_expression (expression) of VGLUT2 associated with glutamate
19) Confidence 0.53 Published 2008 Journal Neuropharmacology Section Title Doc Link 18155072 Disease Relevance 0.06 Pain Relevance 0.26
In contrast to VGLUT1, the different antidepressant treatments did not commonly increase the expression of VGLUT2 or VGLUT3 mRNA.
Gene_expression (expression) of VGLUT2 associated with antidepressant
20) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.26 Pain Relevance 0.61

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