INT107930

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 39
Total Number 42
Disease Relevance 6.53
Pain Relevance 18.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a7)
Anatomy Link Frequency
neurons 9
dorsal horns 4
anterior 2
brain 2
amygdala 2
Slc17a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 292 100.00 Very High Very High Very High
Pain 141 100.00 Very High Very High Very High
Glutamate receptor 76 100.00 Very High Very High Very High
amygdala 19 99.98 Very High Very High Very High
Enkephalin 33 99.92 Very High Very High Very High
antidepressant 55 99.72 Very High Very High Very High
nMDA receptor 63 99.52 Very High Very High Very High
Hippocampus 20 99.50 Very High Very High Very High
cerebral cortex 18 99.24 Very High Very High Very High
Pyramidal cell 97 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 16 99.98 Very High Very High Very High
Cough 360 99.68 Very High Very High Very High
Psychosis 3 99.66 Very High Very High Very High
Shock 16 99.58 Very High Very High Very High
Nociception 65 98.96 Very High Very High Very High
Vibrio Infection 17 97.74 Very High Very High Very High
Cognitive Disorder 16 93.28 High High
Ganglion Cysts 64 91.16 High High
Anxiety Disorder 12 89.20 High High
Myalgia 69 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment.
Gene_expression (expression) of VGLUT1 associated with antidepressant and glutamate
1) Confidence 0.78 Published 2005 Journal J. Neurochem. Section Title Doc Link 15992385 Disease Relevance 0.20 Pain Relevance 0.56
These data suggest that a course of antidepressant drug or ECS treatment increases expression of VGLUT1, a key gene involved in the regulation of glutamate secretion.
Gene_expression (expression) of VGLUT1 associated with glutamate, antidepressant and shock
2) Confidence 0.78 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.34 Pain Relevance 0.57
Immunoautoradiography analysis showed that repeated antidepressant drug treatment increased VGLUT1 protein expression.
Gene_expression (expression) of VGLUT1 associated with antidepressant
3) Confidence 0.78 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.28 Pain Relevance 0.62
This study investigated the effect of antidepressant treatment on expression of the vesicular glutamate transporters, VGLUT1-3 in brain regions of the rat.
Gene_expression (expression) of VGLUT1 in brain associated with glutamate and antidepressant
4) Confidence 0.78 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15992385 Disease Relevance 0.20 Pain Relevance 0.55
Thus, the results indicated in laminae I and II of the medullary and spinal dorsal horns that both VGluT1 and VGluT2 were expressed in axon terminals of primary afferent fibers, including SP-containing nociceptive fibers and that VGluT in unmyelinated primary afferent fibers terminating in lamina II was primarily VGluT2.
Gene_expression (expressed) of VGluT1 in dorsal horns associated with nociception, primary afferent fibers, unmyelinated and substance p
5) Confidence 0.75 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.22 Pain Relevance 0.53
We examined immunohistochemically whether the vesicular glutamate transporters (VGluTs), VGluT1 and VGluT2, might be expressed in synaptic terminals of nociceptive primary afferent fibers within laminae I and II of the medullary and spinal dorsal horns of the rat.
Gene_expression (expressed) of VGluT1 in dorsal horns associated with nociception, glutamate and primary afferent fibers
6) Confidence 0.75 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12541308 Disease Relevance 0.17 Pain Relevance 0.23
Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.
Gene_expression (Expression) of VGluT1 in spinal associated with nociception, pain, glutamate and primary afferent fibers
7) Confidence 0.75 Published 2003 Journal J. Comp. Neurol. Section Title Doc Link 12541308 Disease Relevance 0.19 Pain Relevance 0.44
In contrast, less than 25% of ENKergic cells expressed VGLUT1 in the lateral nucleus of the amygdale, with the majority of ENK cells expressing GAD65 mRNA in this nucleus.
Gene_expression (expressed) of VGLUT1 in nucleus
8) Confidence 0.74 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.25
In addition, ppENK also co-localized with VGLUT1 because more than 95% of ENK cells in the basolateral amygdala expressed VGLUT1.
Gene_expression (expressed) of VGLUT1 in amygdala associated with amygdala
9) Confidence 0.74 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.28
VGLUT1 and -2 expression is mostly segregated to specific divisions of the amygdale, with VGLUT2 being expressed only in the MEA, the anterior cortical nucleus (COAa), and the anterior basomedial nucleus (BMAa), whereas VGLUT1 is expressed in all other divisions of the amygdala.
Gene_expression (expressed) of VGLUT1 in anterior associated with amygdala
10) Confidence 0.74 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.42
Second, we assessed the co-expression of preproenkephalin (ppENK) with GAD65, VGLUT1, or VGLUT2 by using double fluorescent in situ hybridization.
Gene_expression (expression) of VGLUT1
11) Confidence 0.74 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.41
Using immunohistochemistry, we confirmed that annulospiral endings of masseter MSA express the glutamate vesicular transporter VGLUT1, indicating that they can release glutamate.
Gene_expression (express) of VGLUT1 in masseter
12) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link 20559566 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Gene_expression (expressing) of VGluT1-expressing in neurons associated with glutamate
13) Confidence 0.66 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.85
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Gene_expression (expressing) of VGluT1 in neurons associated with glutamate
14) Confidence 0.66 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.87
VGLUT1 and -2 expression is mostly segregated to specific divisions of the amygdale, with VGLUT2 being expressed only in the MEA, the anterior cortical nucleus (COAa), and the anterior basomedial nucleus (BMAa), whereas VGLUT1 is expressed in all other divisions of the amygdala.
Gene_expression (expression) of VGLUT1 in anterior associated with amygdala
15) Confidence 0.65 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.41
We first established the detailed distribution of vesicular glutamate transporters 1 and 2 (VGLUT1 and -2) and glutamate decarboxylase 65 (GAD65) in the amygdala by using in situ hybridization.
Gene_expression (distribution) of VGLUT1 in amygdala associated with glutamate and amygdala
16) Confidence 0.64 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.43
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Gene_expression (positive) of VGluT1 in neurons associated with glutamate
17) Confidence 0.59 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.83
Ventral motor neurons were devoid of cGMP-IR. cGMP-IR was observed in GABAergic, and glutamatergic terminals in all gray matter laminae. cGMP-IR was abundantly colocalized with anti-vesicular glutamate transporter 2 (vGLUT2), however not with the anti-vesicular glutamate transporter 1 (vGLUT1), suggesting a functional difference between structures expressing vGLUT1 or vGLUT2. cGMP-IR did not colocalize with substance P- or calcitonin-gene related peptide-IR structures, however did partially colocalize with isolectin B4 in the dorsal horn. cGMP-IR in cholinergic structures was observed in dorsal root fibers entering the spinal cord, occasionally in laminae 1-3, in laminae 8 and 9 in isolated boutons and in the C-type terminals, and in small cells and varicosities in lamina 10.
Gene_expression (expressing) of vGLUT1 in dorsal horn associated with glutamate, gabaergic, dorsal horn, increased venous pressure under development, spinal cord and substance p
18) Confidence 0.55 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16621445 Disease Relevance 0.08 Pain Relevance 0.52
Because our VGLUT1 data suggested that our IT-type terminal labeling method may have undercounted axospinous terminals in the 0.5 ?
Gene_expression (data) of VGLUT1
19) Confidence 0.55 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2982718 Disease Relevance 0 Pain Relevance 0.06
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Gene_expression (positive) of vesicular glutamate transporter1 in neurons associated with glutamate
20) Confidence 0.51 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.84

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