INT107942

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.86
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) response to stress (C5)
Anatomy Link Frequency
neutrophil 3
spinal 1
C5 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 191 98.60 Very High Very High Very High
Inflammatory response 14 97.80 Very High Very High Very High
chemokine 4 84.12 Quite High
qutenza 6 83.68 Quite High
cytokine 12 83.52 Quite High
cINOD 5 64.92 Quite High
Analgesic 2 63.80 Quite High
Inflammation 48 58.48 Quite High
Arthritis 106 56.56 Quite High
anesthesia 4 37.52 Quite Low
Disease Link Frequency Relevance Heat
Cough 101 100.00 Very High Very High Very High
Cancer 8 99.04 Very High Very High Very High
Necrosis 8 98.80 Very High Very High Very High
Rheumatoid Arthritis 193 98.60 Very High Very High Very High
INFLAMMATION 64 97.80 Very High Very High Very High
Pressure And Volume Under Development 94 97.56 Very High Very High Very High
Infection 30 97.16 Very High Very High Very High
Body Weight 8 92.32 High High
Disease 95 89.84 High High
Sprains And Strains 3 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The midsagittal spinal canal diameter was increased by a mean of 38% and the spinal canal area was increased by an average of 43% at the level of C5.
Positive_regulation (increased) of C5 in spinal
1) Confidence 0.50 Published 2003 Journal Neurosurgery Section Body Doc Link 12535366 Disease Relevance 0 Pain Relevance 0
In humans the gene for C5 is located on Chromosome 9 close to another gene involved in the inflammatory response, TNF receptor-associated factor 1 (TRAF1).
Positive_regulation (located) of C5 associated with inflammatory response
2) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1976626 Disease Relevance 0.81 Pain Relevance 0.38
To investigate whether the TRAF1/C5 region is associated with a specific phenotype of RA, we next stratified patients for autoantibody status from whom baseline ACPA and RF measurements were available (n = 1,814) Interestingly, SNP14/rs10818488 mainly predisposes to autoantibody-positive disease when compared to controls (OR 1.25, 95% CI 1.11–1.40, p = 2.27 × 10?
Spec (whether) Positive_regulation (/) of C5 associated with rheumatoid arthritis and disease
3) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.67 Pain Relevance 0.18
TRAF1/C5: Three SNPs located in the TRAF1/C5 region were identified for investigation, one of which (rs10818488) showed the strongest evidence for association with Dutch RA cases.15 The other two SNPs, rs3761847 and rs2900180, showed the strongest evidence for association in North American and Swedish RA cases.16
Positive_regulation (identified) of C5 associated with rheumatoid arthritis
4) Confidence 0.42 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.82 Pain Relevance 0.41
The area under the curve was significantly increased for mannitol C2 (mean [95% CI] 0.73 [0.54–0.91]; p = 0.039) and C5 (0.72 (0.52–0.91]; p = 0.049).
Positive_regulation (increased) of C5 associated with cough
5) Confidence 0.29 Published 2008 Journal Cough Section Body Doc Link PMC2596167 Disease Relevance 2.34 Pain Relevance 0.08
Five parameters were unique to each classifier, while increased C5 and sL-selectin serum concentration, increased neutrophil percentage or count and elevated hematocrit were selected by both classification methods as discriminant factors.
Positive_regulation (increased) of C5 in neutrophil
6) Confidence 0.28 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.57 Pain Relevance 0.03
Preoperative elevation of the serum level of C3 and C5 complement components, tumor necrosis factor-?
Positive_regulation (elevation) of C5 associated with necrosis and cancer
7) Confidence 0.28 Published 2002 Journal Crit Care Section Abstract Doc Link PMC125311 Disease Relevance 1.02 Pain Relevance 0.11
Staphylococcal superantigen-like 7 (SSL7) is a secreted protein that specifically binds to C5 [36] and thereby prevents C5 activation into C5b and C5a in vitro (J.
Positive_regulation (activation) of C5
8) Confidence 0.17 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.36 Pain Relevance 0
C5 convertases cleave C5 into the anaphylatoxin C5a, which attracts neutrophils to the site of infection, and C5b, which forms a complex with complement proteins C6–C9 to generate the membrane attack complex
Positive_regulation (cleave) of C5 in neutrophils associated with infection
9) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.10 Pain Relevance 0
Modulation of the complement effector functions: inhibiting C5 activation and neutrophil migration
Positive_regulation (activation) of C5 in neutrophil
10) Confidence 0.13 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.17 Pain Relevance 0

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