INT107948

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.94
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bone marrow 1
SpL 1
Spl (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 39 99.36 Very High Very High Very High
Neurotransmitter 1 98.72 Very High Very High Very High
Nicotine 4 97.76 Very High Very High Very High
gABA 11 96.44 Very High Very High Very High
Opioid 4 92.08 High High
agonist 2 90.76 High High
MU agonist 2 85.00 Quite High
antagonist 2 79.76 Quite High
opioid receptor 1 75.00 Quite High
Enkephalin 2 74.16 Quite High
Disease Link Frequency Relevance Heat
Erythrocytosis 81 99.98 Very High Very High Very High
Fibrosis 36 99.36 Very High Very High Very High
Myelodysplastic Syndromes 189 98.32 Very High Very High Very High
Disease 53 95.20 Very High Very High Very High
Hyperplasia 9 92.28 High High
Osteosclerosis 21 90.24 High High
Splenomegaly 39 84.88 Quite High
Reticulocytosis 3 83.36 Quite High
Sprains And Strains 18 70.64 Quite High
Hematological Disease 21 70.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig 3, compared to age-matched, normal B6 mice, megakaryocytosis and reticulin fibrosis is readily identifiable in the bone marrow of both SH and SPL JAK2V617F- transplanted mice.
Gene_expression (bone marrow) of SPL in bone marrow associated with fibrosis
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749451 Disease Relevance 1.17 Pain Relevance 0.20
Thus, a stronger erythropoietic drive has the potential to explain the presence (Epo) or absence (V617F) of polycythemia following SPL in these 2 models.
Gene_expression (following) of SPL associated with erythrocytosis
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749451 Disease Relevance 0.84 Pain Relevance 0
Both B6 and Balb/c mice underwent SH or SPL operations, were allowed to recuperate for 2 weeks, and Aranesp was administered three times over 1 week.
Gene_expression (operations) of SPL
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749451 Disease Relevance 1.38 Pain Relevance 0
Since both cholinergic and enkephalinergic nerves are present in the SpL, the interactions of these two neurotransmitter systems may serve to precisely regulate GABA release in this brain region.
Gene_expression (present) of SpL in SpL associated with gaba and neurotransmitter
4) Confidence 0.07 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535775 Disease Relevance 0 Pain Relevance 1.47
Of these, 4521 were in the SPL group and 4421 were in the PROM group.
Gene_expression (group) of SPL
5) Confidence 0.06 Published 2008 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2386115 Disease Relevance 0.55 Pain Relevance 0
The two Noctilionidae species hunting over water emitted the loudest signals recorded so far for any bat with average source levels of ca. 137 dB SPL and maximum levels above 140 dB SPL.
Gene_expression (source) of SPL
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2323577 Disease Relevance 0 Pain Relevance 0

General Comments

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