INT10795

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Context Info
Confidence 0.36
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.11
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD59) plasma membrane (CD59)
Anatomy Link Frequency
heart 2
blood 1
neural 1
CD59 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 83 98.56 Very High Very High Very High
Etanercept 2 97.88 Very High Very High Very High
Dopamine 10 97.48 Very High Very High Very High
analgesia 14 97.28 Very High Very High Very High
cytokine 5 95.52 Very High Very High Very High
lidocaine 1 90.76 High High
Mexiletine 1 87.12 High High
epidural 4 85.20 High High
anesthesia 4 83.28 Quite High
Arthritis 1 77.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 7 99.04 Very High Very High Very High
INFLAMMATION 95 98.56 Very High Very High Very High
Death 2 97.16 Very High Very High Very High
Chronic Lymphoid Leukemia 94 96.72 Very High Very High Very High
Toxicity 13 93.92 High High
Disease 40 89.44 High High
Residual Neoplasm 6 84.28 Quite High
Cardiovascular Disease 1 81.04 Quite High
Infection 21 79.36 Quite High
Cancer 15 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Before TEA, dopamine 8 micrograms X kg-1 X min-1 decreased systemic vascular resistance 4 +/- 4 mmHg min X 1-1 (m +/- SD) (P less than 0.05), but increased mean arterial pressure 15 +/- 12 mmHg (P less than 0.01), cardiac output 1.9 +/- 1.0 1 X min-1 (P less than 0.01), heart rate 10 +/- 9 beats X min-1 (P less than 0.05), and plasma norepinephrine concentration 544 +/- 252 pg X ml-1 (P less than 0.01).
Positive_regulation (increased) of min-1 in heart associated with dopamine and analgesia
1) Confidence 0.36 Published 1987 Journal Anesthesiology Section Abstract Doc Link 3578878 Disease Relevance 0 Pain Relevance 0.81
Before TEA, dopamine 8 micrograms X kg-1 X min-1 decreased systemic vascular resistance 4 +/- 4 mmHg min X 1-1 (m +/- SD) (P less than 0.05), but increased mean arterial pressure 15 +/- 12 mmHg (P less than 0.01), cardiac output 1.9 +/- 1.0 1 X min-1 (P less than 0.01), heart rate 10 +/- 9 beats X min-1 (P less than 0.05), and plasma norepinephrine concentration 544 +/- 252 pg X ml-1 (P less than 0.01).
Positive_regulation (increased) of min-1 in heart associated with dopamine and analgesia
2) Confidence 0.36 Published 1987 Journal Anesthesiology Section Abstract Doc Link 3578878 Disease Relevance 0 Pain Relevance 0.80
An increase to 72 +/- 25 mL min-1 in the CLH of cortisol to 6 beta-hydroxycortisol was calculated following rifampicin treatment.
Positive_regulation (increase) of min-1
3) Confidence 0.35 Published 1994 Journal Biopharm Drug Dispos Section Abstract Doc Link 8068867 Disease Relevance 0 Pain Relevance 0.13
Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).
Positive_regulation (include) of MIRL
4) Confidence 0.30 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
CBF at normocapnia (PaCO2 42 +/- 2 mmHg) was 33 +/- 7 ml.100 g-1.min-1, which increased to 58 +/- 10 ml.100 g-1.min-1 and decreased to 19 +/- 4 ml.100 g-1.min-1 on increasing PaCO2 (53 +/- 4 mmHg) and decreasing PaCO2 (31 +/- 2 mmHg), respectively.
Positive_regulation (increased) of min-1
5) Confidence 0.14 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1519782 Disease Relevance 0 Pain Relevance 0.29
The term neuroprotectin is applied to protectin that is generated in the neural tissues and has anti-inflammatory properties.[3]
Positive_regulation (generated) of protectin in neural associated with inflammation
6) Confidence 0.14 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933521 Disease Relevance 1.09 Pain Relevance 0.36
Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).
Positive_regulation (include) of CD59
7) Confidence 0.13 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
upregulates CD55 and CD59 antigens,60–64 a combination schedule that combines etanercept, a TNF-?
Positive_regulation (upregulates) of CD59 associated with etanercept
8) Confidence 0.06 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 1.02 Pain Relevance 0.09
Because of thermoregulation skin blood flow rises 15 fold to 100 ml l00 g min-1, often with a time lag of minutes.
Positive_regulation (rises) of min-1 in blood
9) Confidence 0.05 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC544831 Disease Relevance 0 Pain Relevance 0.03

General Comments

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