INT107957

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Git2) kinase activity (Git2)
Anatomy Link Frequency
midbrain 1
Git2 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 3 98.36 Very High Very High Very High
midbrain 7 97.36 Very High Very High Very High
medulla 2 96.20 Very High Very High Very High
opioid receptor 3 95.80 Very High Very High Very High
Kinase C 1 91.56 High High
Sciatic nerve 6 90.20 High High
agonist 3 82.16 Quite High
Kappa opioid receptor 1 81.80 Quite High
Morphine 6 75.00 Quite High
antinociception 2 73.96 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 94.88 High High
Neuropathic Pain 3 44.44 Quite Low
Hyperalgesia 1 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant increase in protein levels of G-protein-coupled receptor kinase 2, which causes receptor phosphorylation in membranes of the lower midbrain but not in the pons/medulla, obtained from mice with nerve injury, whereas there were no changes in the protein level of phosphorylated-protein kinase C in the lower midbrain.
Positive_regulation (increase) of G-protein-coupled receptor kinase 2 in midbrain associated with medulla, kinase c, nervous system injury and midbrain
1) Confidence 0.41 Published 2003 Journal Neuroscience Section Abstract Doc Link 12535942 Disease Relevance 0.17 Pain Relevance 1.38

General Comments

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