INT10796

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Context Info
Confidence 0.77
First Reported 1986
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 131
Total Number 135
Disease Relevance 30.14
Pain Relevance 35.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 35
1A2 14
hepatocytes 5
endometrium 4
brain 3
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 123 100.00 Very High Very High Very High
alcohol 76 100.00 Very High Very High Very High
endometriosis 25 100.00 Very High Very High Very High
Morphine 11 100.00 Very High Very High Very High
Pain 27 99.90 Very High Very High Very High
Buprenorphine 84 99.80 Very High Very High Very High
fluoxetine 35 99.76 Very High Very High Very High
adenocard 9 99.68 Very High Very High Very High
monoamine 14 99.64 Very High Very High Very High
Codeine 15 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 16 100.00 Very High Very High Very High
Sprains And Strains 27 99.98 Very High Very High Very High
Pain 18 99.90 Very High Very High Very High
Glioma 22 99.86 Very High Very High Very High
Nicotine Addiction 218 99.80 Very High Very High Very High
Necrosis 10 99.68 Very High Very High Very High
Metastasis 10 99.68 Very High Very High Very High
Cancer 457 99.56 Very High Very High Very High
Toxicity 124 99.36 Very High Very High Very High
Congenital Anomalies 28 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among 10 heterologously expressed P450s tested, only P450 3A4 was able to dealkylate buprenorphine with a turnover number of 9.6 min(-1).
Gene_expression (expressed) of P450s associated with buprenorphine
1) Confidence 0.77 Published 1997 Journal Life Sci. Section Abstract Doc Link 9180349 Disease Relevance 0 Pain Relevance 0.65
In human liver microsomes with high and low CYP2B6 expression but equivalent CYP3A4 expression, high CYP2B6 expression microsomes generated twice the amount of EDDP from 10 microg/ml of methadone than low CYP2B6 expression microsomes.
Gene_expression (expression) of CYP2B6 in liver associated with methadone
2) Confidence 0.77 Published 2004 Journal Chirality Section Abstract Doc Link 14628297 Disease Relevance 0 Pain Relevance 1.20
In human liver microsomes with high and low CYP2B6 expression but equivalent CYP3A4 expression, high CYP2B6 expression microsomes generated twice the amount of EDDP from 10 microg/ml of methadone than low CYP2B6 expression microsomes.
Gene_expression (expression) of CYP2B6 in liver associated with methadone
3) Confidence 0.77 Published 2004 Journal Chirality Section Abstract Doc Link 14628297 Disease Relevance 0 Pain Relevance 1.15
In human liver microsomes with high and low CYP2B6 expression but equivalent CYP3A4 expression, high CYP2B6 expression microsomes generated twice the amount of EDDP from 10 microg/ml of methadone than low CYP2B6 expression microsomes.
Gene_expression (expression) of CYP2B6 in liver associated with methadone
4) Confidence 0.77 Published 2004 Journal Chirality Section Abstract Doc Link 14628297 Disease Relevance 0 Pain Relevance 1.17
We evaluated the efficacies of NSAIDs to inhibit NNK activation by h1A2 v2 cells expressing human P-450 1A2.
Gene_expression (expressing) of P-450 in 1A2 associated with cinod
5) Confidence 0.76 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9163687 Disease Relevance 0.29 Pain Relevance 0.50
In human lymphoblast-expressed P450, the activities of CYP2B6 were higher than those of CYP3A4 and CYP2C9 at three concentrations of ketamine, 0.005, 0.05, and 0.5 mM.
Gene_expression (expressed) of P450 in lymphoblast associated with ketamine
6) Confidence 0.76 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 12065445 Disease Relevance 0 Pain Relevance 0.54
The cytochrome P450 responsible for the debrisoquine/sparteine polymorphism (P450 2D6) has been produced in large quantities by expression of a modified cDNA in baculovirus.
Gene_expression (produced) of P450
7) Confidence 0.75 Published 1996 Journal Biochemistry Section Abstract Doc Link 8605204 Disease Relevance 0 Pain Relevance 0.05
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression.
Gene_expression (expression) of P450 in PC-12
8) Confidence 0.75 Published 1993 Journal Eur. J. Biochem. Section Title Doc Link 8391436 Disease Relevance 0.16 Pain Relevance 0.05
Variable cytochrome P450 2D6 expression and metabolism of codeine and other opioid prodrugs: implications for the Australian anaesthetist.
Gene_expression (expression) of P450 associated with anesthesia, opioid and codeine
9) Confidence 0.75 Published 2000 Journal Anaesth Intensive Care Section Title Doc Link 11153286 Disease Relevance 0 Pain Relevance 0.84
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human cytochromes P450 (CYP).
Gene_expression (expressed) of P450 in liver
10) Confidence 0.75 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10997936 Disease Relevance 0 Pain Relevance 0.04
Four heterologously expressed P450 proteins were able to catalyze the N-demethylation of methadone, namely, P450 2C8, P450 2C18, P450 2D6, and P450 3A4.
Gene_expression (expressed) of P450 associated with methadone
11) Confidence 0.75 Published 1996 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8839037 Disease Relevance 0 Pain Relevance 0.63
OBJECTIVE: The aim of this study was to assess the drug interaction potential of psychotropic medication on methadone N-demethylation using cDNA-expressed cytochrome P450 CYP enzymes.
Gene_expression (expressed) of P450 associated with methadone
12) Confidence 0.75 Published 2007 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 17598095 Disease Relevance 0 Pain Relevance 0.17
All three compounds produced negligible inhibition of P450-1A2, -2C9, -2E1, and -3A.
Gene_expression (produced) of P450 in 1A2
13) Confidence 0.75 Published 1998 Journal J Clin Psychopharmacol Section Abstract Doc Link 9690701 Disease Relevance 0 Pain Relevance 0.15
Accordingly, an Ames tester strain was described that was genetically engineered so as to express both aromatic amine N-acetyltransferase and human cytochrome P450 1A2.
Gene_expression (express) of P450 in 1A2 associated with sprains and strains
14) Confidence 0.75 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8884021 Disease Relevance 0.35 Pain Relevance 0.09
Analysis of liver microsomes from patients treated with metamizole revealed selectively higher expression of cytochromes P450, CYP2B6 and CYP3A4 (3.8- and 2.8-fold, respectively), and 2.9-fold higher bupropion hydroxylase activity compared with untreated subjects.
Gene_expression (expression) of P450 in liver
15) Confidence 0.75 Published 2007 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17344806 Disease Relevance 0 Pain Relevance 0.10
Of six expressed human P450 isoforms (P450s 1A2, 2B6, 2C9, 2D6, 2E1, and 3A4), only P450 3A4 exhibited significant fentanyl dealkylation to norfentanyl.
Gene_expression (expressed) of P450 in 1A2
16) Confidence 0.75 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9311623 Disease Relevance 0 Pain Relevance 0.08
Intestinal and hepatic first-pass metabolism, as well as systemic metabolism, may be subject to individual variability in P450 3A4 expression and to drug interactions involving P450 3A4.
Gene_expression (expression) of P450
17) Confidence 0.75 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9311623 Disease Relevance 0 Pain Relevance 0.07
The human hepatocytes expressed human albumin, human cytochrome P450 enzymes, and human transporter proteins.
Gene_expression (expressed) of P450 in hepatocytes
18) Confidence 0.75 Published 2008 Journal Toxicol Pathol Section Abstract Doc Link 18467679 Disease Relevance 0.32 Pain Relevance 0.33
An immunoperoxidase test was used to reveal the expression of cytochrome P-450 aromatase in the eutopic and ectopic endometrium of 14 patients with ovarian endometriosis and 26 with adenomyosis, whose age ranged from 21 to 47 years (38+/-2.0 years).
Gene_expression (expression) of P-450 in endometrium associated with endometriosis and dismenorea
19) Confidence 0.75 Published 2008 Journal Arkh. Patol. Section Abstract Doc Link 19137777 Disease Relevance 0.41 Pain Relevance 0.21
Capillary electrophoresis (CE) with multiwavelength absorbance detection is demonstrated to be an effective tool for the assessment of in vitro drug metabolism studies using microsomes containing single human cytochrome P450 enzymes (CYPs) expressed in baculovirus-infected insect cells (Supersomes).
Gene_expression (expressed) of P450 in Capillary
20) Confidence 0.75 Published 2003 Journal Electrophoresis Section Abstract Doc Link 12900870 Disease Relevance 0 Pain Relevance 0.35

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