INT107960

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ncoa1) nucleus (Ncoa1) transferase activity, transferring acyl groups (Ncoa1)
DNA binding (Ncoa1) signal transducer activity (Ncoa1)
Anatomy Link Frequency
intermediary 1
null cell 1
Ncoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 1 76.52 Quite High
Inflammation 18 50.00 Quite Low
tolerance 18 46.40 Quite Low
agonist 22 31.68 Quite Low
Somatostatin 1 28.72 Quite Low
Dopamine 1 26.96 Quite Low
antagonist 2 25.00 Low Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 98.44 Very High Very High Very High
Embryonic Lethality 3 87.16 High High
Precocious Puberty 1 87.04 High High
Syndrome 1 83.80 Quite High
Hypopituitarism 1 77.92 Quite High
Reprotox - General 2 1 77.08 Quite High
Headache 1 76.52 Quite High
Pituitary Cancer 3 74.40 Quite High
Body Weight 14 69.52 Quite High
Targeted Disruption 17 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of nuclear coactivators such as steroid receptor coactivator 1 (SRC1) and transcriptional intermediary factor 2 (TIF2) prevented the ER?
Positive_regulation (receptor) of SRC1 in intermediary
1) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.17 Pain Relevance 0
Studies on the role of germ-line deletion of coactivators SRC-1, SRC-2, and SRC-3 in the mouse revealed that none of these are essential for PPAR?
Positive_regulation (coactivators) of SRC-1
2) Confidence 0.10 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.28 Pain Relevance 0
The tumors can be divided into two broad categories: functioning gonadotropinomas with positive immunostaining for follicle-stimulating hormone, leutinizing hormone, and/or their subunits; and nonfunctioning gonadotropinomas or null cell tumors with negative immunostaining for all pituitary hormones but positive nuclear immunostaining for steroid factor-1 or DAX-1 characteristic of gonadotrope differentiation, with evidence of gonadotropin production or gene expression at the mRNA level.
Positive_regulation (immunostaining) of steroid factor-1 in null cell associated with cancer
3) Confidence 0.01 Published 2002 Journal Semin. Reprod. Med. Section Abstract Doc Link 12536357 Disease Relevance 1.14 Pain Relevance 0.08

General Comments

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