INT107961

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 11.69
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
pituitary 14
fibroblast 2
lactotrope 2
Pttg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 331 99.60 Very High Very High Very High
agonist 79 84.76 Quite High
headache 12 62.32 Quite High
dopamine receptor 22 60.68 Quite High
Somatostatin 1 60.56 Quite High
antagonist 1 53.44 Quite High
Disease Link Frequency Relevance Heat
Pituitary Cancer 289 100.00 Very High Very High Very High
Galactorrhea 66 99.48 Very High Very High Very High
Aneuploidy 11 99.44 Very High Very High Very High
Cancer 262 99.32 Very High Very High Very High
Prolactinoma 462 98.44 Very High Very High Very High
Adenoma 33 98.24 Very High Very High Very High
Aging 66 96.80 Very High Very High Very High
Targeted Disruption 242 93.56 High High
Hypertrophy 11 91.00 High High
Hyperplasia 121 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In young female rats treated with a synthetic estrogen (DES 20 mg) pituitary weight and serum prolactin levels were increased as expected (Table 1), and PTTG protein expression was enhanced as well (P = 0.029, Figure 2B).
Positive_regulation (enhanced) of Gene_expression (expression) of PTTG in pituitary
1) Confidence 0.38 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.18 Pain Relevance 0.13
Therefore, low estrogenic input at the pituitary level may be insufficient to promote pttg expression.
Positive_regulation (promote) of Gene_expression (expression) of pttg in pituitary
2) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.93 Pain Relevance 0.04
In accordance with the literature, we describe a marked increase in pituitary PTTG expression in the estrogen-treated rats.
Positive_regulation (increase) of Gene_expression (expression) of PTTG in pituitary
3) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.88 Pain Relevance 0.10
But, we describe that PTTG expression is not increased in human dopamine resistant when compared to dopamine responsive prolactinomas.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of PTTG associated with dopamine and prolactinoma
4) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.81 Pain Relevance 0.13
Furthermore, PTTG overexpression results in focal pituitary hyperplasia and adenoma formation [18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG in pituitary associated with adenoma and pituitary cancer
5) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.31 Pain Relevance 0.07
This is consistent with experimental animal results presented herein which demonstrate that reduced dopaminergic action at the pituitary is associated with pituitary enlargement, hyperprolactinemia but not necessarily with increased PTTG expression.
Neg (not) Positive_regulation (increased) of Neg (not) Gene_expression (expression) of PTTG in pituitary associated with galactorrhea
6) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.66 Pain Relevance 0.12
So even though PTTG expression is increased in rapidly proliferating cells in some experimental models supporting that it may play a role in the control of cell proliferation, we postulate that it does not participate in the prolactinoma development caused by deficient dopamine control of the lactotrope.
Positive_regulation (increased) of Gene_expression (expression) of PTTG in lactotrope associated with dopamine and prolactinoma
7) Confidence 0.25 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.78 Pain Relevance 0.13
Overexpressed PTTG induces cell aneuploidy, transforms NIH3T3 cells in vitro and in vivo, stimulates basic fibroblast growth factor (FGF-2) production, and stimulates proliferation and angiogenesis.
Positive_regulation (Overexpressed) of Gene_expression (Overexpressed) of PTTG in fibroblast associated with aneuploidy
8) Confidence 0.22 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.77 Pain Relevance 0
PTTG must be proteolysed during cell division for sister chromatid separation to occur, and failure in this process, as in PTTG overexpression, elicits inappropriate sister chromatid exchange, resulting in genetic instability as an early tumorigenic event [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG
9) Confidence 0.22 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.62 Pain Relevance 0
In humans, pttg overexpression in pituitary tumors has been demonstrated [19-21], but controversies on correlation between pttg levels and tumor behaviour or type exist.
Positive_regulation (overexpression) of Gene_expression (overexpression) of pttg in pituitary associated with cancer and pituitary cancer
10) Confidence 0.22 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.42 Pain Relevance 0.05
But, in young female rats treated with a synthetic estrogen (Diethylstylbestrol, 20 mg) PTTG protein expression was enhanced (P = 0.029).
Positive_regulation (enhanced) of Gene_expression (expression) of PTTG
11) Confidence 0.22 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1779802 Disease Relevance 1.09 Pain Relevance 0.11
A new pituitary oncogene, pituitary tumor transforming gene, has recently been found to be overexpressed in about two thirds of these tumors but it is also detected in all other pituitary tumor subtypes.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of pituitary tumor transforming in pituitary associated with cancer and pituitary cancer
12) Confidence 0.02 Published 2002 Journal Semin. Reprod. Med. Section Abstract Doc Link 12536357 Disease Relevance 1.24 Pain Relevance 0.20

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