INT107962

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 34.05
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
pituitary 21
lactotrope 4
testis 1
sphenoid bone 1
fibroblast 1
Pttg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 935 99.80 Very High Very High Very High
agonist 223 98.52 Very High Very High Very High
metalloproteinase 6 98.08 Very High Very High Very High
dopamine receptor 62 86.72 High High
headache 33 71.04 Quite High
Somatostatin 1 60.56 Quite High
antagonist 1 53.44 Quite High
imagery 24 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 843 100.00 Very High Very High Very High
Galactorrhea 186 99.88 Very High Very High Very High
Prolactinoma 1306 99.84 Very High Very High Very High
Cancer 871 99.82 Very High Very High Very High
Targeted Disruption 682 99.68 Very High Very High Very High
Lymphatic System Cancer 31 99.60 Very High Very High Very High
Aneuploidy 31 99.44 Very High Very High Very High
Leukemia 93 99.04 Very High Very High Very High
Adenoma 100 98.64 Very High Very High Very High
Hyperplasia 349 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a homolog of securine PTTG regulates the cell cycle and higher expression of PTTG was noted in pituitary adenomas.
Gene_expression (expression) of PTTG in pituitary associated with pituitary cancer
1) Confidence 0.53 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.68 Pain Relevance 0.03
In fact, abundant and concordant PTTG and bFGF expression in different human pituitary tumors was described [4].
Gene_expression (expression) of PTTG in pituitary associated with pituitary cancer
2) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.90 Pain Relevance 0.11
Furthermore, we found low expression of PTTG in D2R knockout compared to wildtype mice despite similar pttg transcripts.
Gene_expression (expression) of PTTG associated with targeted disruption
3) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.89 Pain Relevance 0.14
Nevertheless, PTTG protein expression is sensitive to high estrogen levels, which decreases dopaminergic control of the lactotrope.
Gene_expression (expression) of PTTG in lactotrope
4) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.29 Pain Relevance 0.18
In senescent rats no difference in pituitary PTTG protein expression was found when compared to young rats (Figure 2A).
Gene_expression (expression) of PTTG in pituitary
5) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.10 Pain Relevance 0.13
In young female rats treated with a synthetic estrogen (DES 20 mg) pituitary weight and serum prolactin levels were increased as expected (Table 1), and PTTG protein expression was enhanced as well (P = 0.029, Figure 2B).
Gene_expression (expression) of PTTG in pituitary
6) Confidence 0.42 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.17 Pain Relevance 0.13
Expression of the pituitary tumor transforming gene (PTTG) and HIF-1?
Gene_expression (Expression) of PTTG in pituitary associated with pituitary cancer
7) Confidence 0.41 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.10 Pain Relevance 0
Experimentally, PTTG has also been shown to be regulated by exposure to estrogen [23, 39] and our results demonstrated that lowered levels of PTTG were observed in the E2+G6-31 group.
Gene_expression (levels) of PTTG
8) Confidence 0.40 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.66 Pain Relevance 0
Therefore, low estrogenic input at the pituitary level may be insufficient to promote pttg expression.
Gene_expression (expression) of pttg in pituitary
9) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.93 Pain Relevance 0.04
In accordance with the literature, we describe a marked increase in pituitary PTTG expression in the estrogen-treated rats.
Gene_expression (expression) of PTTG in pituitary
10) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.87 Pain Relevance 0.10
Therefore, in the three experimental models of prolactinomas pituitary size was increased and there was hyperprolactinemia, but PTTG expression followed different patterns.


Gene_expression (expression) of PTTG in pituitary associated with galactorrhea and prolactinoma
11) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.18 Pain Relevance 0.09
Expression of the pituitary tumor transforming gene (PTTG) and HIF-1?
Gene_expression (Expression) of tumor transforming in pituitary associated with pituitary cancer
12) Confidence 0.36 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.10 Pain Relevance 0
This is consistent with experimental animal results presented herein which demonstrate that reduced dopaminergic action at the pituitary is associated with pituitary enlargement, hyperprolactinemia but not necessarily with increased PTTG expression.
Neg (not) Gene_expression (expression) of PTTG in pituitary associated with galactorrhea
13) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.66 Pain Relevance 0.11
Furthermore, anti-estrogens reduced PTTG expression in human pituitary tumors in vitro (three gonadotroph, five nonfunctioning) and suppressed experimental tumor growth in vivo [29].
Gene_expression (expression) of PTTG in pituitary associated with cancer and pituitary cancer
14) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.91 Pain Relevance 0.12
Furthermore, PTTG overexpression results in focal pituitary hyperplasia and adenoma formation [18].
Gene_expression (overexpression) of PTTG in pituitary associated with adenoma and pituitary cancer
15) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.31 Pain Relevance 0.07
PTTG is expressed in high levels in different pituitary tumors [8] and other neoplasms including carcinomas of lung, breast, colon, thyroid, adrenal, liver, kidney, endometrium, uterus, ovary leukemia and lymphomas [9].
Gene_expression (expressed) of PTTG in pituitary associated with leukemia, lymphatic system cancer, cancer, pituitary cancer and carcinoma
16) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.93 Pain Relevance 0.03
But, we describe that PTTG expression is not increased in human dopamine resistant when compared to dopamine responsive prolactinomas.
Gene_expression (expression) of PTTG associated with dopamine and prolactinoma
17) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 0.80 Pain Relevance 0.13
On the other hand, high estrogen levels could impact on PTTG expression.
Gene_expression (expression) of PTTG
18) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.12 Pain Relevance 0.22
PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes

Background

Gene_expression (expression) of PTTG in lactotropes associated with prolactinoma
19) Confidence 0.33 Published 2007 Journal Mol Cancer Section Title Doc Link PMC1779802 Disease Relevance 0.79 Pain Relevance 0.10
The expression of PTTG in normal tissues is restricted, with highest expression in the testis.
Gene_expression (expression) of PTTG in testis
20) Confidence 0.33 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1779802 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

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