INT107965

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.91
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
plasma membrane (HLA-B) cytoplasm (Mefv)
Anatomy Link Frequency
juvenile 1
HLA-B (Homo sapiens)
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 13 100.00 Very High Very High Very High
Arthritis 10 100.00 Very High Very High Very High
Inflammation 3 71.32 Quite High
Disease Link Frequency Relevance Heat
Fever 18 100.00 Very High Very High Very High
Low Back Pain 13 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 9 100.00 Very High Very High Very High
Arthropathy 3 99.16 Very High Very High Very High
Inflammatory Bowel Disease 1 86.20 High High
Arthritis 1 76.56 Quite High
Disease 3 71.80 Quite High
INFLAMMATION 3 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of FMF and AS (usually without the HLA-B27 antigen) has been well documented, although the pathogenic mechanisms that link these two conditions remain unknown.
HLA-B27 Binding (association) of FMF associated with spinal inflammation and fever
1) Confidence 0.34 Published 2002 Journal Joint Bone Spine Section Abstract Doc Link 12537263 Disease Relevance 2.02 Pain Relevance 0.54
The association of familial Mediterranean fever (FMF) with juvenile idiopathic arthritis (JIA) or ankylosing spondylitis (AS), most commonly with negative HLA-B27 antigen, was described in several previous reports, although the pathogenic mechanism of this association still remains unknown.
HLA-B27 Binding (association) of FMF in juvenile associated with spinal inflammation, fever, juvenile chronic polyarthritis and arthritis
2) Confidence 0.04 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16307274 Disease Relevance 0.82 Pain Relevance 0.54
Herein we report an uncommon association of FMF with HLA-B27 positive AS as an occasional coincidence in a patient who had been diagnosed as having JIA 23 years previously.
HLA-B27 Binding (association) of FMF associated with spinal inflammation, fever and arthritis
3) Confidence 0.04 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16307274 Disease Relevance 1.06 Pain Relevance 0.54

General Comments

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