INT107968

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.27
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
MIA PaCa-2 2
lung 1
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 185 99.62 Very High Very High Very High
qutenza 6 98.98 Very High Very High Very High
aspirin 11 98.72 Very High Very High Very High
cINOD 19 93.68 High High
COX-2 inhibitor 2 78.92 Quite High
cytokine 48 78.32 Quite High
Prostatitis 33 74.88 Quite High
Inflammatory stimuli 37 66.84 Quite High
corticosteroid 56 50.00 Quite Low
agonist 8 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 291 99.92 Very High Very High Very High
Pneumonia 1 99.62 Very High Very High Very High
Stress 24 95.64 Very High Very High Very High
Infection 56 95.12 Very High Very High Very High
INFLAMMATION 269 92.24 High High
Pancreatic Cancer 15 92.20 High High
Htlv Types I And Ii 4 92.08 High High
Cancer 104 91.00 High High
Leukemia 7 83.68 Quite High
Squamous Cell Carcinoma 3 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parthenolide treatment also dose-dependently increased the amount of the NF-kappa B inhibitory protein, I kappa B-alpha, and decreased NF-kappa B DNA binding activity.
Positive_regulation (increased) of I kappa B-alpha
1) Confidence 0.46 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.52 Pain Relevance 0.33
Increased levels of I kappa B-alpha protein were detected, especially in MIA PaCa-2 cells, after treatment with parthenolide and sulindac compared with each agent alone.
Positive_regulation (Increased) of I kappa B-alpha in MIA PaCa-2
2) Confidence 0.46 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.53 Pain Relevance 0.39
Increased levels of I kappa B-alpha protein were detected, especially in MIA PaCa-2 cells, after treatment with parthenolide and sulindac compared with each agent alone.
Positive_regulation (levels) of I kappa B-alpha in MIA PaCa-2
3) Confidence 0.31 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.53 Pain Relevance 0.39
The induction of NFKBIA might be a response to the increased levels of NF-?
Positive_regulation (induction) of NFKBIA
4) Confidence 0.31 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.36 Pain Relevance 0
Another example of increased expression due to the STS was seen in the induction of NFKBIA; there was approximately a 7-fold increase in WTSTS cells compared to a 3-fold increase in the U versus WT comparison.
Positive_regulation (induction) of NFKBIA
5) Confidence 0.27 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.22 Pain Relevance 0
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
Positive_regulation (up-regulation) of I kappa-B alpha associated with qutenza
6) Confidence 0.25 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.60 Pain Relevance 0.44
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Positive_regulation (stimulated) of IkBa
7) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.09
This induction takes place in the absence of peroxisome proliferator-response elements (PPRE), but requires the presence of NF-kappaB and Sp1 elements in the IkappaB alpha promoter sequence as well as DRIP250 cofactors [59].
Positive_regulation (requires) of IkappaB alpha
8) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.24 Pain Relevance 0.18
of IkB, induction of TSC22, NF-kB, GADD153, PTEN, etc.) may depend on the
Spec (may) Positive_regulation (depend) of IkB
9) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.80 Pain Relevance 0
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (activation) of IkappaB-alpha associated with aspirin
10) Confidence 0.05 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64
B, resulting in lung inflammation.30 Phosphorylated IKBa was significantly increased in rats with CP and was significantly decreased in the oligonol-administrated group, suggesting that oligonol inhibits E2-induced CP by regulating phosphorylation of I?
Positive_regulation (increased) of IKBa in lung associated with inflammation and pneumonia
11) Confidence 0.05 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703763 Disease Relevance 0.65 Pain Relevance 0.24

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