INT107971

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.03
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 59 99.54 Very High Very High Very High
qutenza 6 98.92 Very High Very High Very High
cytokine 28 85.92 High High
Inflammatory stimuli 2 75.04 Quite High
Osteoarthritis 4 75.00 Quite High
Pain 4 57.12 Quite High
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 73 99.54 Very High Very High Very High
Apoptosis 12 97.40 Very High Very High Very High
Htlv Types I And Ii 4 91.96 High High
Leukemia 5 83.56 Quite High
Arthritis 12 76.64 Quite High
Osteoarthritis 4 75.00 Quite High
Disease 22 65.00 Quite High
Pain 2 57.12 Quite High
Aging 21 50.00 Quite Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Neg (without) Regulation (affecting) of IkappaBalpha-ubiquitination
1) Confidence 0.24 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.16 Pain Relevance 0.40
Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.
Regulation (regulation) of I kappa-B alpha associated with qutenza
2) Confidence 0.13 Published 2003 Journal Leuk. Res. Section Abstract Doc Link 12537981 Disease Relevance 0.60 Pain Relevance 0.44
PPAR alpha (Peroxisome proliferator-activated receptor alpha) negatively interferes with inflammatory gene expression by up-regulation of the cytoplasmic inhibitor molecule IkappaB alpha, thus establishing an autoregulatory loop.
Regulation (regulation) of IkappaB alpha associated with inflammation
3) Confidence 0.12 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.27 Pain Relevance 0.20

General Comments

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