INT107983

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.57
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH6) ATPase activity (MSH6) nucleus (MSH6)
Anatomy Link Frequency
SW480 1
MSH6 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 96.20 Very High Very High Very High
metalloproteinase 9 63.84 Quite High
Inflammatory response 1 55.96 Quite High
aspirin 10 50.00 Quite Low
Arthritis 15 48.56 Quite Low
Inflammation 22 48.16 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
pain pelvic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 99 99.96 Very High Very High Very High
Endometrial Cancer 315 99.44 Very High Very High Very High
Cancer 280 98.32 Very High Very High Very High
Stress 20 97.88 Very High Very High Very High
Rheumatoid Arthritis 68 96.20 Very High Very High Very High
Skin Cancer 16 88.80 High High
Carcinoma 127 87.92 High High
Hyperplasia 40 86.32 High High
Ductal Carcinoma 1 67.12 Quite High
Colon Cancer 22 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, MSH6 mutations seem to be a frequent cause of MSI [11, 12].
Gene_expression (mutations) of MSH6 associated with microsatellite instability
1) Confidence 0.51 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.34 Pain Relevance 0
RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].
Gene_expression (promote) of MSH6 associated with microsatellite instability and endometrial cancer
2) Confidence 0.51 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.70 Pain Relevance 0
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of MSH6
3) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.50 Pain Relevance 0.03
In HCT116+chr3 cells, treatment with 1 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2.5-fold and 2-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 2-3-fold.
Gene_expression (expression) of hMSH6
4) Confidence 0.18 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
For SW480 cells, treatment with 1 and 5 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2-4-fold and 3-5-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 3-7-fold.
Gene_expression (expression) of hMSH6 in SW480
5) Confidence 0.18 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
In addition, there is increasing evidence that p63 may act as an oncogene in the tumorigenesis of endometrial carcinomas and its expression is significantly associated with high histologic grade, higher mitotic count and tumor cell proliferation, Ki-67 expression, microsatellite instability (MSI) and loss of hMSH6 expression [6].
Gene_expression (expression) of hMSH6 associated with cancer, microsatellite instability and endometrial cancer
6) Confidence 0.10 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.08 Pain Relevance 0
Evidence for this comes from findings of decreased expression of hMSH6, a component of the MutS?
Gene_expression (expression) of hMSH6
7) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.94 Pain Relevance 0.24

General Comments

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