INT107985

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 31.31
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
Anatomy Link Frequency
MLH1 8
colon 2
SW480 1
rectum 1
bowel 1
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 96.96 Very High Very High Very High
Inflammation 10 95.64 Very High Very High Very High
aspirin 12 88.24 High High
cINOD 19 87.60 High High
alcohol 4 84.68 Quite High
Piles 3 75.00 Quite High
Bile 87 72.04 Quite High
Taxol 4 70.52 Quite High
Pain 3 68.60 Quite High
palliative 6 59.84 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 299 100.00 Very High Very High Very High
Pancreatic Cancer 51 99.98 Very High Very High Very High
Cancer 904 99.58 Very High Very High Very High
Colorectal Cancer 367 99.52 Very High Very High Very High
Microsatellite Instability 250 99.26 Very High Very High Very High
Endometrial Cancer 237 98.86 Very High Very High Very High
Colon Cancer 374 98.68 Very High Very High Very High
Adenocarcinoma 20 98.56 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 250 98.48 Very High Very High Very High
Inflammatory Bowel Disease 28 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry (IHC) on surgical specimens was as follows: MLH1 stained negative and MSH2 stained positive in all tumors (Fig. 3), strongly suggesting a mutation in MLH1.
Neg (negative) Gene_expression (stained) of MLH1 in MLH1 associated with cancer
1) Confidence 0.67 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 1.03 Pain Relevance 0.04
Probes were designed to determine dosage for a range of CFH exons, along with control probes for MSH2 exon 1 and MLH1 exon 19 (NM_000251, NM_000249).
Gene_expression (exon) of MLH1 in MLH1
2) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
Primers that amplify MLH1 exon 14 and BRCA1 exon 16 were included in the assay as controls for normal dosage.
Gene_expression (exon) of MLH1 in MLH1
3) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
The tumor specimens showed no MLH1 expression but did show normal MSH2 expression. p53 was not expressed.
Neg (no) Gene_expression (expression) of MLH1 in MLH1 associated with cancer
4) Confidence 0.64 Published 2007 Journal J Nippon Med Sch Section Abstract Doc Link 17878704 Disease Relevance 2.69 Pain Relevance 0.11
Microsatellite status and immunohistochemistry for MLH1 and MSH2 expression were determined by the Institute for Pathology at the University Hospital Bonn, which is one of the reference centres for diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) in Germany.
Gene_expression (expression) of MLH1 in MLH1 associated with colorectal cancer
5) Confidence 0.61 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492852 Disease Relevance 1.10 Pain Relevance 0
Familial CRC patients showed normal expression of MLH1 and MSH2 in tumor tissues, and microsatellite instability was excluded in all patients.
Gene_expression (expression) of MLH1 in MLH1 associated with colorectal cancer, cancer and microsatellite instability
6) Confidence 0.61 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492852 Disease Relevance 1.03 Pain Relevance 0
Although multiple malignancies in the colon and rectum are not infrequent in HNPCC, prophylactic colectomy is still not recommended.
Neg (not) Gene_expression (infrequent) of HNPCC in rectum
7) Confidence 0.58 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.71 Pain Relevance 0
NC and RB carried out MLH1 and MSH2 staining as well as microsatellite testing in colorectal cancers.
Gene_expression (staining) of MLH1 in MLH1 associated with colorectal cancer
8) Confidence 0.53 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492852 Disease Relevance 0.65 Pain Relevance 0.07
Although multiple malignancies in the colon and rectum are not infrequent in HNPCC, prophylactic colectomy is still not recommended.
Neg (not) Gene_expression (infrequent) of HNPCC in colon
9) Confidence 0.20 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.71 Pain Relevance 0
CONCLUSION: Ductal pancreatic carcinomas express hMLH1 and hMLH2 proteins irrespective of their differentiation.
Gene_expression (express) of hMLH1 associated with pancreatic cancer
10) Confidence 0.18 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.42 Pain Relevance 0.09
Expression of the DNA mismatch repair proteins (hMLH1 and hMSH2) in infiltrating pancreatic cancer and its relation to some phenotypic features.
Gene_expression (Expression) of hMLH1 associated with pancreatic cancer
11) Confidence 0.18 Published 2003 Journal Pol J Pathol Section Title Doc Link 12817878 Disease Relevance 1.33 Pain Relevance 0.12
The purpose of the present study was to evaluate the expression of hMLH1 and hMLH2 proteins in infiltrating pancreatic cancer and to find out whether there is a relationship between some phenotypic manifestations and expression of MMR genes.
Gene_expression (expression) of hMLH2 associated with pancreatic cancer
12) Confidence 0.18 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.35 Pain Relevance 0.14
CONCLUSION: Ductal pancreatic carcinomas express hMLH1 and hMLH2 proteins irrespective of their differentiation.
Gene_expression (express) of hMLH2 associated with pancreatic cancer
13) Confidence 0.18 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.42 Pain Relevance 0.09
The purpose of the present study was to evaluate the expression of hMLH1 and hMLH2 proteins in infiltrating pancreatic cancer and to find out whether there is a relationship between some phenotypic manifestations and expression of MMR genes.
Gene_expression (expression) of hMLH1 associated with pancreatic cancer
14) Confidence 0.18 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.35 Pain Relevance 0.14
In sporadic colorectal tumours, germline mutations of MMR genes are rare in tumours that are MSI-high, but lack of expression of MLH1 has been found to be very common (up to 95%) in sporadic MSI+ tumours and is thought to be due to hypermethylation of the promoter region of MLH1 gene [111].
Gene_expression (expression) of MLH1 in MLH1 associated with colorectal cancer and cancer
15) Confidence 0.18 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.63 Pain Relevance 0
In HCT116+chr3 cells, treatment with 1 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2.5-fold and 2-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 2-3-fold.
Gene_expression (expression) of hMLH1
16) Confidence 0.17 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
For SW480 cells, treatment with 1 and 5 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2-4-fold and 3-5-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 3-7-fold.
Gene_expression (expression) of hMLH1 in SW480
17) Confidence 0.17 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
We studied 30 cases of infiltrating pancreatic cancer and apart from hMLH1 and hMLH2 expression cytokeratin 7 and chromogranin were measured as markers of ductal and endocrine differentiation, respectively.
Gene_expression (expression) of hMLH1 associated with pancreatic cancer
18) Confidence 0.14 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.51 Pain Relevance 0.13
We studied 30 cases of infiltrating pancreatic cancer and apart from hMLH1 and hMLH2 expression cytokeratin 7 and chromogranin were measured as markers of ductal and endocrine differentiation, respectively.
Gene_expression (expression) of hMLH2 associated with pancreatic cancer
19) Confidence 0.14 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.51 Pain Relevance 0.13
Small bowel cancer in patients with HNPCC occurs at a young age (median age of 39), and the duodenum involves 50% of the cases.11 As a result, regular upper endoscopy surveillance of patients with FAP/HNPCC should be started around the time of colectomy or after the age of 30.11

IBD

Gene_expression (/) of HNPCC in bowel associated with colorectal cancer, inflammatory bowel disease and familial adenomatous polyposis
20) Confidence 0.09 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990396 Disease Relevance 1.95 Pain Relevance 0.03

General Comments

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