INT107987

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 36
Disease Relevance 36.94
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MRC1) plasma membrane (MRC1)
Anatomy Link Frequency
dendritic cell 4
monocytes 1
muscle 1
colon 1
fibroblasts 1
MRC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 10 99.36 Very High Very High Very High
rheumatoid arthritis 136 97.76 Very High Very High Very High
Inflammation 129 96.24 Very High Very High Very High
anesthesia 92 92.96 High High
Chronic pancreatitis 1 90.40 High High
cytokine 80 88.12 High High
halothane 60 87.68 High High
cINOD 12 86.28 High High
ischemia 4 72.60 Quite High
Inflammatory mediators 12 56.08 Quite High
Disease Link Frequency Relevance Heat
Rubella Virus Infection 720 100.00 Very High Very High Very High
Togavirus Infection 222 100.00 Very High Very High Very High
Muscle Rigidity 72 100.00 Very High Very High Very High
Adhesions 67 100.00 Very High Very High Very High
Malignant Hyperthermia 676 99.98 Very High Very High Very High
Microsatellite Instability 56 99.92 Very High Very High Very High
Cancer 153 99.60 Very High Very High Very High
Immunization 338 99.44 Very High Very High Very High
Systemic Lupus Erythematosus 672 99.32 Very High Very High Very High
Rhabdomyolysis 56 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to evaluate the expression of hMLH1 and hMLH2 proteins in infiltrating pancreatic cancer and to find out whether there is a relationship between some phenotypic manifestations and expression of MMR genes.
Gene_expression (expression) of MMR associated with pancreatic cancer
1) Confidence 0.75 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.45 Pain Relevance 0.13
CONCLUSIONS: We conclude that aspirin acts through COX-independent mechanisms by resulting in an increase in MMR protein expression and subsequent apoptosis, which might serve as an additional means of growth inhibition in aspirin-treated human colon cancer cells.


Gene_expression (expression) of MMR protein in colon
2) Confidence 0.50 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
The work reported here eliminates the remaining support for the hypothesis that ASD with GI complaints is related to MMR exposure.
Gene_expression (exposure) of MMR associated with togavirus infection
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2526159 Disease Relevance 1.11 Pain Relevance 0.03
There were no significant differences in the proportion of cases and controls with MMR before onset of GI episodes: 12 of 25 cases (48%) received MMR before GI episodes began as compared with 3 of 13 controls (23%; P?
Gene_expression (controls) of MMR associated with togavirus infection
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2526159 Disease Relevance 1.19 Pain Relevance 0.06
Timing of MMR, GI episodes and AUT
Gene_expression (Timing) of MMR associated with togavirus infection
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2526159 Disease Relevance 0.83 Pain Relevance 0.09
There were no significant differences in the proportion of cases and controls with MMR before onset of GI episodes: 12 of 25 cases (48%) received MMR before GI episodes began as compared with 3 of 13 controls (23%; P?
Gene_expression (received) of MMR associated with togavirus infection
6) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2526159 Disease Relevance 1.29 Pain Relevance 0.06
We hypothesized that aspirin treatment might alter expression of DNA mismatch repair (MMR) proteins, representing another potential non-COX mechanism for its action.
Gene_expression (expression) of MMR associated with aspirin
7) Confidence 0.34 Published 2003 Journal Clin. Cancer Res. Section Abstract Doc Link 12538492 Disease Relevance 0.51 Pain Relevance 0.34
Nieminen et al. [26] studied serial endometrial biopsy samples taken during a 10-year followup of HPNCC mutation carriers and found abnormal MMR protein expression, MSI, or tumor suppressor promotor hypermethylation in various endometrial histologies, including normal and hyperplastic endometria.
Gene_expression (expression) of MMR protein associated with cancer, microsatellite instability and hyperplasia
8) Confidence 0.19 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 2.22 Pain Relevance 0
In June 1984 the Health Council advised that MMR be introduced to the Dutch immunisation programme.
Gene_expression (introduced) of MMR associated with immunization and rubella virus infection
9) Confidence 0.18 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.46 Pain Relevance 0
First, we try to establish that the decision to introduce MMR in the Netherlands was the outcome of a protracted process in the course of which the significance of different kinds of evidence changed.
Gene_expression (introduce) of MMR associated with rubella virus infection
10) Confidence 0.18 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 0.50 Pain Relevance 0
Anticipating the forthcoming change in the immunisation programme, RIV (that in 1984 was reorganised as RIVM), continued negotiations with this and two other manufacturers regarding production of MMR under licence.
Gene_expression (production) of MMR associated with rubella virus infection and immunization
11) Confidence 0.18 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.42 Pain Relevance 0
Their MMR vaccine was licensed in 1971, alongside the individual vaccines.
Gene_expression (vaccine) of MMR associated with rubella virus infection
12) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.34 Pain Relevance 0
Since low coverage rates had long been a matter of concern in the USA the combination vaccine had particular advantages, and MMR began to be used routinely by the mid 1970s.
Gene_expression (used) of MMR associated with rubella virus infection
13) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.40 Pain Relevance 0
Introduction of MMR
Gene_expression (Introduction) of MMR associated with rubella virus infection
14) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 0.55 Pain Relevance 0
This conceptual framework leads to a refinement of the first claim we will try to develop: changes in ‘what counted as evidence’ through the course of MMR decision-making should be viewed in the light of changes in the context in which decision-making took place.


Gene_expression (decision) of MMR associated with rubella virus infection
15) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 0.95 Pain Relevance 0
Negotiations with Merck’s European subsidiary (MSD) regarding the production of mumps vaccine under license began in 1982, but broke down when it became clear the company would consider licensing its combined MMR vaccine, but not the single mumps component.
Gene_expression (vaccine) of MMR associated with mumps and rubella virus infection
16) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.33 Pain Relevance 0
In September 1985 the government Minister responsible requested the Health Insurance Council (Ziekenfondsraad) to consider the financial implications of introducing MMR.
Gene_expression (introducing) of MMR associated with rubella virus infection
17) Confidence 0.16 Published 2010 Journal Social Science & Medicine (1982) Section Body Doc Link PMC2941041 Disease Relevance 1.40 Pain Relevance 0
T cell-induced expression of CD206 and CD209 in co-cultures (Fig. 4C).
Gene_expression (expression) of CD206 in T cell
18) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.06 Pain Relevance 0.03
HMB-PP-activated monocytes expressed CD83, CD206 (mannose receptor) and CD209 (DC-SIGN) (Fig. 4C), while CD205 (DEC-205) and CD207 (langerin) were absent (Table S1).
Gene_expression (expressed) of CD206 in monocytes
19) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0
First, the decision to introduce MMR was not one but a series of decisions going back at least seven years, over the course of which the significance attached to various forms of evidence changed.
Gene_expression (introduce) of MMR associated with rubella virus infection
20) Confidence 0.14 Published 2010 Journal Social Science & Medicine (1982) Section Abstract Doc Link PMC2941041 Disease Relevance 0.46 Pain Relevance 0

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