INT107988

Context Info Confidence 0.40 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.56 Pain Relevance 0

endosome (MRC1) plasma membrane (MRC1)

Anatomy Link Frequency colon 1 MRC1 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 5 50.00 Taxol 1 31.44 alcohol 19 5.00 addiction 2 5.00 cINOD 2 5.00 imagery 2 5.00 drug abuse 1 5.00 abdominal pain 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Familial Adenomatous Polyposis 1 98.90 Disease 36 95.40 Colon Cancer 22 78.00 Cancer 26 63.36 Reprotox - General 1 7 51.52 Leukemia 1 51.00 Carcinoma 9 50.00 Communicable Diseases 15 32.48 Chronic Disease 13 30.72 Cleidocranial Dysplasia 1 17.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

EXPERIMENTAL DESIGN: In this study, we have examined the effects of aspirin on the cellular growth rates, MMR protein levels, cell cycle analysis and apoptosis in MMR-deficient (HCT116) and MMR-proficient (HCT116+chr3 and SW480) human colon cancer cell lines.

Spec (examined) Regulation (effects) of MMR protein in colon

1) Confidence 0.40 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0

However, unlike familial adenomatous polyposis, very little is known about phenotypic variation as a function of the MMR gene involved or the location and nature of the specific MMR gene mutation.

Regulation (function) of MMR gene associated with familial adenomatous polyposis

2) Confidence 0.14 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 0.51 Pain Relevance 0

Major efforts to control and reduce MMR in Cuba include: continued training of maternity personnel; major emphasis to primary health; and creation and expansion of clinics, hospitals, and health centers in the country [62].

Regulation (control) of MMR

3) Confidence 0.10 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898047 Disease Relevance 0.05 Pain Relevance 0

General Comments

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