INT107989

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MRC1) plasma membrane (MRC1)
Anatomy Link Frequency
colon 2
T cell 2
MRC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 56.08 Quite High
Inflammation 32 50.00 Quite Low
aspirin 5 50.00 Quite Low
cytokine 16 31.92 Quite Low
chemokine 18 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 56.08 Quite High
Colon Cancer 3 50.00 Quite Low
Infection 30 5.00 Very Low Very Low Very Low
Peritonitis 15 5.00 Very Low Very Low Very Low
Renal Failure 13 5.00 Very Low Very Low Very Low
Bacterial Infection 7 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Mycobacterial Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We conclude that aspirin acts through COX-independent mechanisms by resulting in an increase in MMR protein expression and subsequent apoptosis, which might serve as an additional means of growth inhibition in aspirin-treated human colon cancer cells.


Positive_regulation (increase) of Gene_expression (expression) of MMR protein in colon
1) Confidence 0.45 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
T cell-induced expression of CD206 and CD209 in co-cultures (Fig. 4C).
Positive_regulation (induced) of Gene_expression (expression) of CD206 in T cell
2) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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