INT107991

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH6) ATPase activity (MSH6) nucleus (MSH6)
Anatomy Link Frequency
SW480 2
MSH6 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 10 50.00 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 49 99.84 Very High Very High Very High
Cancer 85 98.32 Very High Very High Very High
Endometrial Cancer 153 92.12 High High
Carcinoma 61 87.92 High High
Hyperplasia 18 86.32 High High
Colon Cancer 14 50.00 Quite Low
Endometroid Carcinoma 21 26.48 Quite Low
Endometrial Stromal Sarcoma 39 5.00 Very Low Very Low Very Low
Carcinosarcoma 29 5.00 Very Low Very Low Very Low
Sarcoma 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, MSH6 mutations seem to be a frequent cause of MSI [11, 12].
Positive_regulation (cause) of Gene_expression (mutations) of MSH6 associated with microsatellite instability
1) Confidence 0.38 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.35 Pain Relevance 0
In HCT116+chr3 cells, treatment with 1 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2.5-fold and 2-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 2-3-fold.
Positive_regulation (increased) of Gene_expression (expression) of hMSH6
2) Confidence 0.16 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0
For SW480 cells, treatment with 1 and 5 mM of aspirin increased expression of the hMLH1 and hPMS2 proteins by 2-4-fold and 3-5-fold, respectively, and increased expression of the hMSH2 and hMSH6 proteins by 3-7-fold.
Positive_regulation (increased) of Gene_expression (expression) of hMSH6 in SW480
3) Confidence 0.12 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12538492 Disease Relevance 0 Pain Relevance 0

General Comments

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