INT107992

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 37.09
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
Anatomy Link Frequency
MLH1 9
colon 2
rectum 2
ascending colon 2
urinary bladder 1
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 135 97.08 Very High Very High Very High
cINOD 15 97.04 Very High Very High Very High
Pain 17 90.28 High High
Piles 6 75.00 Quite High
Bile 79 71.68 Quite High
Taxol 2 69.48 Quite High
cytokine 22 63.48 Quite High
metalloproteinase 6 63.36 Quite High
aspirin 10 50.00 Quite Low
Chronic pancreatitis 1 49.08 Quite Low
Disease Link Frequency Relevance Heat
Cancer 537 99.84 Very High Very High Very High
Adenoma 90 99.84 Very High Very High Very High
Colon Cancer 178 99.66 Very High Very High Very High
Skin Cancer 102 99.66 Very High Very High Very High
Oral Lichen Planus 385 99.52 Very High Very High Very High
Colorectal Cancer 290 99.52 Very High Very High Very High
Microsatellite Instability 303 99.46 Very High Very High Very High
Endometroid Carcinoma 12 99.44 Very High Very High Very High
Malignant Neoplastic Disease 95 99.20 Very High Very High Very High
Myeloid Leukemia 30 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSH2 expression in adenoma cases was lower than in controls by 49% (P = 0.01) and 23% (P = 0.06) in the ascending colon and rectum, respectively, but not in the sigmoid colon.
Gene_expression (expression) of MSH2 in colon associated with adenoma
1) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.57 Pain Relevance 0.08
To characterize the expression of the mismatch repair gene MSH2 in normal colorectal crypts in humans and assess parameters of its expression as a potential modifiable biomarker of risk for colorectal neoplasms, we conducted a pilot, colonoscopy-based case-control study (51 cases and 154 controls) of incident, sporadic colorectal adenoma.
Gene_expression (expression) of MSH2 associated with adenoma and colorectal cancer
2) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.32 Pain Relevance 0
These preliminary data suggest that lower MSH2 expression in the normal colonic mucosa, at least in the ascending colon and rectum, may be associated with increased risk of incident, sporadic colorectal adenoma as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MSH2 expression as a potential modifiable biomarker of risk for colorectal neoplasms.
Gene_expression (expression) of MSH2 in rectum associated with colorectal cancer and adenoma
3) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.85 Pain Relevance 0.09
MSH2 expression in the rectum was 39% (P = 0.04) higher in subjects who regularly took a nonsteroidal anti-inflammatory drug than in those who did not, and it tended to be lower in those with adenomas in the right colon and those who had an adenoma with more advanced characteristics.
Gene_expression (expression) of MSH2 in colon associated with adenoma, inflammation and cinod
4) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.73 Pain Relevance 0.10
Colorectal mucosal expression of MSH2 as a potential biomarker of risk for colorectal neoplasms.
Gene_expression (expression) of MSH2 associated with colorectal cancer
5) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Title Doc Link 19861524 Disease Relevance 0.53 Pain Relevance 0.07
These preliminary data suggest that lower MSH2 expression in the normal colonic mucosa, at least in the ascending colon and rectum, may be associated with increased risk of incident, sporadic colorectal adenoma as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MSH2 expression as a potential modifiable biomarker of risk for colorectal neoplasms.
Gene_expression (expression) of MSH2 in rectum associated with colorectal cancer and adenoma
6) Confidence 0.78 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.81 Pain Relevance 0.08
In the present study, we demonstrated decreased expression of hMSH2 protein in reticular and atrophic/erosive OLP compared to oral normal mucosa.
Gene_expression (expression) of hMSH2 associated with oral lichen planus
7) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.34 Pain Relevance 0.03
hMSH2 is especially expressed in human cells that are undergoing rapid renewal: in the lower-two thirds of gastrointestinal glands 15, in the more primitive testicular germ cells 28, in the transitional epithelial cells of the bladder 20, and in the basal cell line of epidermis and oral mucosa 29.
Gene_expression (expressed) of hMSH2 in transitional epithelial cells
8) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.64 Pain Relevance 0.18
Moreover, Lo Muzio et al. 29 reported that 5% of the cases of oral squamous cell carcinoma show diminished expression of hMSH2 protein.
Gene_expression (expression) of hMSH2 associated with skin cancer
9) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.39 Pain Relevance 0.03
Immunohistochemical study on non-polyposis colorectal cancer demonstrated no expression of hMSH2 gene in the tumoral cells 15.
Neg (no) Gene_expression (expression) of hMSH2 associated with colon cancer
10) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.91 Pain Relevance 0.09
With regard to sporadic forms of tumors, reduced expression of hMSH2 have been reported in a distinct subset of oral and neck squamous cell 16, colorectal 17, endometrial 18, ovarian 19 and urinary bladder carcinomas 20.
Gene_expression (expression) of hMSH2 in urinary bladder associated with cancer and bladder cancer
11) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.84 Pain Relevance 0.09
Therefore, the reduced expression of hMSH2 protein could make the epithelium of OLP more susceptible to DNA mutation, making it prone to oral squamous cell carcinoma development.
Gene_expression (expression) of hMSH2 in epithelium associated with oral lichen planus and skin cancer
12) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.21 Pain Relevance 0
These tumors show high frequency of microsatellite instability and are immunohistochemically characterized by the lack of hMSH2 protein expression 15.
Gene_expression (expression) of hMSH2 associated with cancer and microsatellite instability
13) Confidence 0.75 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.46 Pain Relevance 0.06
Probes were designed to determine dosage for a range of CFH exons, along with control probes for MSH2 exon 1 and MLH1 exon 19 (NM_000251, NM_000249).
Gene_expression (exon) of MSH2 in MLH1
14) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
The genetic damage in exposed individuals was measured by means of the comet test, chromosomal alterations test, and the study of the CYP 1A1 and MSH2 genes.
Gene_expression (study) of MSH2
15) Confidence 0.65 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991910 Disease Relevance 0.55 Pain Relevance 0.09
Our study also found that As exposure has a profound negative impact on DNA repair, decreasing positive expression for XRCC1, MGMT, and hMSH2 mRNA with the increasing severity of skin lesion in arsenicosis patients (Table 3).
Gene_expression (expression) of hMSH2 in skin
16) Confidence 0.65 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
Immunohistochemistry (IHC) on surgical specimens was as follows: MLH1 stained negative and MSH2 stained positive in all tumors (Fig. 3), strongly suggesting a mutation in MLH1.
Gene_expression (stained) of MSH2 in MLH1 associated with cancer
17) Confidence 0.64 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 0.97 Pain Relevance 0.03
The tumor specimens showed no MLH1 expression but did show normal MSH2 expression. p53 was not expressed.
Gene_expression (expression) of MSH2 in MLH1 associated with cancer
18) Confidence 0.64 Published 2007 Journal J Nippon Med Sch Section Abstract Doc Link 17878704 Disease Relevance 2.67 Pain Relevance 0.10
Microsatellite status and immunohistochemistry for MLH1 and MSH2 expression were determined by the Institute for Pathology at the University Hospital Bonn, which is one of the reference centres for diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) in Germany.
Gene_expression (expression) of MSH2 in MLH1 associated with colorectal cancer
19) Confidence 0.63 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492852 Disease Relevance 1.10 Pain Relevance 0
Familial CRC patients showed normal expression of MLH1 and MSH2 in tumor tissues, and microsatellite instability was excluded in all patients.
Gene_expression (expression) of MSH2 in MLH1 associated with colorectal cancer, cancer and microsatellite instability
20) Confidence 0.63 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2492852 Disease Relevance 1.03 Pain Relevance 0

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