INT1080

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 343
Total Number 346
Disease Relevance 108.51
Pain Relevance 72.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 28
plasma 8
muscle 7
erythrocyte 6
blood 5
Ache (Rattus norvegicus)
Ache - A2M (1)
Pain Link Frequency Relevance Heat
Dopamine 268 100.00 Very High Very High Very High
Glutamate 120 100.00 Very High Very High Very High
gABA 109 100.00 Very High Very High Very High
medulla 92 100.00 Very High Very High Very High
Serotonin 89 100.00 Very High Very High Very High
cerebral cortex 88 100.00 Very High Very High Very High
monoamine 61 100.00 Very High Very High Very High
midbrain 45 100.00 Very High Very High Very High
opiate 40 100.00 Very High Very High Very High
tetrodotoxin 100 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 239 100.00 Very High Very High Very High
Cv General 3 Under Development 38 99.98 Very High Very High Very High
Disease 2212 99.96 Very High Very High Very High
INFLAMMATION 146 99.96 Very High Very High Very High
Heart Rate Under Development 121 99.96 Very High Very High Very High
Headache 136 99.92 Very High Very High Very High
Psychosis 68 99.90 Very High Very High Very High
Cognitive Disorder 943 99.88 Very High Very High Very High
Delirium 6 99.88 Very High Very High Very High
Vomiting 331 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of AChE was decreased significantly in castrated rats, but this effect was reversed by treatment with testosterone.
Negative_regulation (decreased) of AChE
1) Confidence 0.59 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3683767 Disease Relevance 0 Pain Relevance 0.61
Three days after the termination of treatment with morphine and on the last day of treatment with ethanol, a significant inhibition of the activity of AChE was detected.
Negative_regulation (inhibition) of AChE associated with morphine
2) Confidence 0.59 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3683767 Disease Relevance 0 Pain Relevance 0.48
Although the 2,5-HD concentration that inhibited AChE activity is high compared to that attainable in occupationally exposed workers, these data are useful in understanding the neurotoxicity of this compound.
Negative_regulation (inhibited) of AChE associated with drug induced neurotoxicity
3) Confidence 0.59 Published 2004 Journal Toxicol. Lett. Section Abstract Doc Link 14687764 Disease Relevance 0.10 Pain Relevance 0.07
A number of C(4)-C9 aliphatic ketones, including 2,5-hexanedione (2,5-HD), are acetylcholinesterase (AChE; EC 3.1.1.7) inhibitors.
Negative_regulation (inhibitors) of AChE
4) Confidence 0.59 Published 2004 Journal Toxicol. Lett. Section Abstract Doc Link 14687764 Disease Relevance 0 Pain Relevance 0.10
Although we observed significant inhibition of acetylcholinesterase (AChE) in blood and a significant decrease in body weight gain at this dose, no change in blood pressure, heart rate or respiratory rate was registered.
Negative_regulation (inhibition) of acetylcholinesterase in body associated with body weight, cv unclassified under development and weight gain
5) Confidence 0.59 Published 2008 Journal Toxicology Section Abstract Doc Link 18614271 Disease Relevance 0.46 Pain Relevance 0
Although we observed significant inhibition of acetylcholinesterase (AChE) in blood and a significant decrease in body weight gain at this dose, no change in blood pressure, heart rate or respiratory rate was registered.
Negative_regulation (inhibition) of AChE in body associated with body weight, cv unclassified under development and weight gain
6) Confidence 0.59 Published 2008 Journal Toxicology Section Abstract Doc Link 18614271 Disease Relevance 0.46 Pain Relevance 0
Binocular injections of TTX result in a reduction of AChE activity in layer IV throughout cortical area 17, similar to the effects of binocular enucleation on PND 3.
Negative_regulation (reduction) of AChE associated with tetrodotoxin
7) Confidence 0.59 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.08 Pain Relevance 0.59
Previous work has demonstrated that neonatal enucleations markedly reduce the transient AChE activity in visual cortex.
Negative_regulation (reduce) of AChE in cortex
8) Confidence 0.59 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0 Pain Relevance 0.24
The degree of reduction of AChE activity from repeated TTX injections was similar to the degree of reduction following enucleation on PND 3.
Negative_regulation (reduction) of AChE associated with tetrodotoxin
9) Confidence 0.59 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.07 Pain Relevance 0.57
These experiments show that uniocular injections result in a markedly decreased level of AChE activity in layer IV of the medial part of cortical area 17 contralateral to the injected eye.
Negative_regulation (level) of AChE in eye
10) Confidence 0.59 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2706772 Disease Relevance 0.06 Pain Relevance 0.54
Low baseline levels of acetylcholine (about 0.3 pmol/15 min sample) could be detected in the absence of acetylcholinesterase inhibition in all animals.
Negative_regulation (inhibition) of acetylcholinesterase
11) Confidence 0.59 Published 1990 Journal Neuroscience Section Abstract Doc Link 2215927 Disease Relevance 0 Pain Relevance 0.11
In anaesthetized rats, reduction in HR and mean arterial pressure by vagus nerve stimulation (1-20 Hz) was more pronounced in females than in males after inhibition of acetylcholinesterase with physostigmine. 4.
Negative_regulation (inhibition) of acetylcholinesterase in vagus nerve associated with vagus nerve
12) Confidence 0.59 Published 1994 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7982279 Disease Relevance 0 Pain Relevance 0.20
Inhibitors of AChE are used to delay cognitive decline and EEG slowing in patients with Alzheimer's disease.
Negative_regulation (Inhibitors) of AChE associated with cognitive disorder and disease
13) Confidence 0.59 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804611 Disease Relevance 0.20 Pain Relevance 0.62
We suggest that doses of AChE inhibitors required for these effects can be reduced by concurrent 5-HT stimulation.
Negative_regulation (inhibitors) of AChE
14) Confidence 0.59 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11804611 Disease Relevance 0.10 Pain Relevance 0.58
Nizatidine, a histamine H(2)-antagonist, is known to inhibit acetylcholinesterase (AChE) activity and is used clinically as a gastroprokinetic agent as well as the anti-ulcer agent.
Negative_regulation (inhibit) of acetylcholinesterase associated with antagonist and ulcers
15) Confidence 0.59 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595432 Disease Relevance 0.10 Pain Relevance 0.17
Nizatidine, a histamine H(2)-antagonist, is known to inhibit acetylcholinesterase (AChE) activity and is used clinically as a gastroprokinetic agent as well as the anti-ulcer agent.
Negative_regulation (inhibit) of AChE associated with antagonist and ulcers
16) Confidence 0.59 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595432 Disease Relevance 0.10 Pain Relevance 0.17
We examined whether or not nizatidine stimulates duodenal HCO(3)(-) secretion in rats through vagal-cholinergic mechanisms by inhibiting AChE activity.
Spec (whether) Negative_regulation (inhibiting) of AChE
17) Confidence 0.59 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595432 Disease Relevance 0.09 Pain Relevance 0.18
It is assumed that reduction in AChE activity is an adaptive mechanism by which the excitability of hippocampal inhibitory basket cells, which are sensitive to acetylcholine, is increased.
Negative_regulation (reduction) of AChE in basket cells
18) Confidence 0.59 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6402039 Disease Relevance 0 Pain Relevance 0.30
Experiments on rats with electrochemotrodes implanted in the left and right hippocamp have shown that in epileptogenic foci created by microinjections of met-enkephalin or D-ala-2-met-enkephalin into the hippocamp, acetylcholinesterase activity (AChE) was diminished.
Negative_regulation (diminished) of acetylcholinesterase associated with enkephalin
19) Confidence 0.59 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6402039 Disease Relevance 0 Pain Relevance 0.31
Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve.
Negative_regulation (Distribution) of AChE in anterior
20) Confidence 0.59 Published 2010 Journal Eur J Histochem Section Title Doc Link 20353912 Disease Relevance 0.08 Pain Relevance 0.19

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