INT108021

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Context Info
Confidence 0.00
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
MC3 2
Pomc (Mus musculus)
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 6 97.16 Very High Very High Very High
antagonist 10 91.32 High High
Serotonin 2 77.60 Quite High
antidepressant 6 75.00 Quite High
Eae 4 25.00 Low Low
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 6 97.16 Very High Very High Very High
Anxiety Disorder 10 96.56 Very High Very High Very High
Stress 6 50.24 Quite High
Shock 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MCL0129 inhibited [(125)I][Nle(4)-D-Phe(7)]-alpha-melanocyte-stimulating hormone (alpha-MSH) binding to MC4 receptor with a K(i) value of 7.9 nM, without showing affinity for MC1 and MC3 receptors.
alpha-MSH Binding (binding) of MC4 in MC3
1) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538838 Disease Relevance 0.48 Pain Relevance 0.27
MCL0129 inhibited [(125)I][Nle(4)-D-Phe(7)]-alpha-melanocyte-stimulating hormone (alpha-MSH) binding to MC4 receptor with a K(i) value of 7.9 nM, without showing affinity for MC1 and MC3 receptors.
alpha-melanocyte-stimulating hormone Binding (binding) of MC4 in MC3
2) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538838 Disease Relevance 0.49 Pain Relevance 0.28

General Comments

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