INT10806

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.74
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 4
anterior pituitary 4
muscle 2
adrenal gland 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 99.96 Very High Very High Very High
MU agonist 2 99.76 Very High Very High Very High
Opioid 15 99.34 Very High Very High Very High
Morphine 23 98.86 Very High Very High Very High
dexamethasone 16 98.26 Very High Very High Very High
antagonist 5 97.12 Very High Very High Very High
Nicotine 7 96.76 Very High Very High Very High
withdrawal 7 94.92 High High
Endogenous opioid 7 93.28 High High
amygdala 2 92.60 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 10 99.68 Very High Very High Very High
Stress 14 99.48 Very High Very High Very High
Hypotension 4 75.00 Quite High
Heart Rate Under Development 3 75.00 Quite High
Pressure And Volume Under Development 10 67.36 Quite High
Aids-related Complex 3 59.12 Quite High
INFLAMMATION 8 46.40 Quite Low
Hyperglycemia 2 46.00 Quite Low
Necrosis 1 43.68 Quite Low
Hyperalgesia 6 23.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Northern blot analysis showed that forskolin (10 microM) increased the abundance of POMC mRNA 1.4 fold above that of vehicle treated control cultures.
Positive_regulation (increased) of Transcription (abundance) of POMC mRNA
1) Confidence 0.50 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.35
Whereas by itself, DM (10 nM) had little effect on the level of POMC mRNA, it enhanced forskolin-stimulated increase of the abundance of POMC mRNA approximately 2.6 times.
Positive_regulation (increase) of Transcription (abundance) of POMC mRNA associated with dexamethasone
2) Confidence 0.50 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.33
In general, chronic treatment with a kappa opioid agonist results in increases in the concentration of beta-endorphin in specific tissues.
Positive_regulation (increases) of Transcription (concentration) of beta-endorphin associated with mu agonist
3) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8113998 Disease Relevance 0 Pain Relevance 0.48
Levels of transcripts for mRNA for both CRF and POMC were markedly reduced after the treatment, but there was a rapid return to control values for CRF mRNA within 18 h of steroid withdrawal.
Positive_regulation (Levels) of Transcription (transcripts) of POMC associated with withdrawal
4) Confidence 0.49 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.13 Pain Relevance 0.08
Results of RT-PCR demonstrated that the mRNA level of POMC in the adrenal gland markedly increased in STZ-diabetic rats as compared with that in normal rats.
Positive_regulation (increased) of Transcription (level) of POMC in adrenal gland associated with diabetes mellitus
5) Confidence 0.49 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.64 Pain Relevance 0.19
These findings indicate that pCMV–POMC mRNA was transcribed in the transfected muscle (Fig. 6).


Positive_regulation (transfected) of Transcription (transcribed) of POMC mRNA in muscle
6) Confidence 0.46 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400409 Disease Relevance 0.13 Pain Relevance 0.03
The employed stress paradigm also induced an elevation of anterior pituitary levels of PRL and POMC mRNAs.
Positive_regulation (elevation) of Transcription (levels) of POMC in anterior pituitary associated with stress
7) Confidence 0.45 Published 1994 Journal Peptides Section Abstract Doc Link 7984495 Disease Relevance 0.63 Pain Relevance 0.42
In sharp contrast to proenkephalin RNA, the abundance of POMC RNA remained relatively constant throughout the estrous cycle in both tissues.
Positive_regulation (constant) of Transcription (abundance) of POMC RNA
8) Confidence 0.43 Published 1988 Journal Endocrinology Section Abstract Doc Link 3345721 Disease Relevance 0 Pain Relevance 0.14
Treatment of rats for 4 days with alpha-methyldopa, 200 mg/kg/day i.p., increases steady state levels of proopiomelanocortin (POMC) mRNA in the mediobasal hypothalamus, as measured by DNA excess solution hybridization.
Positive_regulation (increases) of Transcription (levels) of proopiomelanocortin in hypothalamus
9) Confidence 0.41 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8677016 Disease Relevance 0.15 Pain Relevance 0.07
Determination of relative opioid mRNA levels revealed a dramatic increase of pro-opiomelanocortin (POMC) mRNA concentrations in response to lead.
Positive_regulation (increase) of Transcription (concentrations) of pro-opiomelanocortin associated with opioid
10) Confidence 0.40 Published 1989 Journal Brain Res. Section Abstract Doc Link 2765905 Disease Relevance 0 Pain Relevance 0.28
When castrated male rats were similarly morphine pelleted and killed either on day 10 or 2 days later after pellet removal, the mean POMC mRNA level again fell from 1.83 +/- 0.21 in the controls to 1.28 +/- 0.20 pg/microgram RNA after 10 days of morphine; 2 days after pellet removal levels remained suppressed at 0.80 +/- 0.08 pg/microgram RNA (P < 0.01).
Positive_regulation (fell) of Transcription (level) of POMC mRNA associated with morphine
11) Confidence 0.39 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8883945 Disease Relevance 0 Pain Relevance 0.76
Nicotine treatment resulted in an increase in the pro-opiomelanocortin mRNA levels in the anterior pituitary and in a decrease in the intermediate pituitary, but did not change the levels of pro-opiomelanocortin mRNA in the hypothalamus.
Neg (not) Positive_regulation (change) of Transcription (levels) of pro-opiomelanocortin in anterior pituitary associated with nicotine
12) Confidence 0.32 Published 1992 Journal Clin Investig Section Abstract Doc Link 1521036 Disease Relevance 0 Pain Relevance 0.65
Currently, we tested the hypothesis that chronic morphine, which produces down-regulation of mu-opioid receptors, causes a down-regulation of pro-opiomelanocortin (POMC, the precursor of beta-EP) mRNA expression in female guinea pig hypothalamus.
Positive_regulation (causes) of Transcription (expression) of pro-opiomelanocortin in hypothalamus associated with mu opioid receptor and morphine
13) Confidence 0.11 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645954 Disease Relevance 0.06 Pain Relevance 0.79

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