INT108066

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.56
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) aging (Ngf)
extracellular space (Ngf) signal transduction (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
Nerve 2
PC-12 1
autonomic 1
NTRK1 (Homo sapiens)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 26 100.00 Very High Very High Very High
intrathecal 2 88.08 High High
Dorsal horn 2 82.12 Quite High
headache 2 77.80 Quite High
cytokine 6 75.00 Quite High
Spinal cord 6 75.00 Quite High
Glutamate 2 70.80 Quite High
gABA 2 68.64 Quite High
antidepressant 2 51.84 Quite High
Inflammation 4 41.28 Quite Low
Disease Link Frequency Relevance Heat
Autonomic Dysreflexia 10 98.60 Very High Very High Very High
Apoptosis 4 98.40 Very High Very High Very High
Frailty 12 93.60 High High
Autonomic Nervous System Disease 2 93.16 High High
Injury 4 91.00 High High
Headache 2 77.80 Quite High
Hypertension 2 77.08 Quite High
Stress 2 48.40 Quite Low
INFLAMMATION 4 41.28 Quite Low
Depression 4 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve growth factor (NGF) binds to TrkA receptors (neurotrophic) and P75(NTR) (apoptosis or other pathways depending on the coupled adaptor proteins).
TrkA Binding (binds) of NGF in Nerve associated with nerve growth factor and apoptosis
1) Confidence 0.33 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.10 Pain Relevance 0.23
Nerve growth factor (NGF) binds to TrkA receptors (neurotrophic) and P75(NTR) (apoptosis or other pathways depending on the coupled adaptor proteins).
TrkA Binding (binds) of Nerve growth factor in Nerve associated with nerve growth factor and apoptosis
2) Confidence 0.33 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.10 Pain Relevance 0.23
Binding of our trkA-IgG fusion protein was specific for NGF with a K(d) = 4.26 x 10(-11) M and blocked NGF-dependent neuritogenesis in PC-12 cells.
trkA Binding (Binding) of NGF in PC-12 associated with nerve growth factor
3) Confidence 0.05 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12542855 Disease Relevance 1.18 Pain Relevance 0.61
We hypothesized that binding of NGF in the injured cord by our trkA-IgG fusion protein would diminish autonomic dysreflexia.
trkA Binding (binding) of NGF in autonomic associated with autonomic dysreflexia and nerve growth factor
4) Confidence 0.05 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12542855 Disease Relevance 1.17 Pain Relevance 0.59

General Comments

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