INT108067

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.38
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) aging (Ngf)
extracellular space (Ngf) signal transduction (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
PC-12 2
autonomic 2
NTRK1 (Homo sapiens)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 20 100.00 Very High Very High Very High
intrathecal 2 90.80 High High
Dorsal horn 2 82.12 Quite High
headache 2 77.80 Quite High
Spinal cord 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Autonomic Dysreflexia 10 99.96 Very High Very High Very High
Frailty 12 96.32 Very High Very High Very High
Autonomic Nervous System Disease 2 93.16 High High
Injury 4 91.00 High High
Apoptosis 2 86.96 High High
Headache 2 77.80 Quite High
Hypertension 2 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of our trkA-IgG fusion protein was specific for NGF with a K(d) = 4.26 x 10(-11) M and blocked NGF-dependent neuritogenesis in PC-12 cells.
Negative_regulation (blocked) of trkA Binding (Binding) of NGF in PC-12 associated with nerve growth factor
1) Confidence 0.06 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12542855 Disease Relevance 1.20 Pain Relevance 0.61
We hypothesized that binding of NGF in the injured cord by our trkA-IgG fusion protein would diminish autonomic dysreflexia.
Negative_regulation (diminish) of trkA Binding (binding) of NGF in autonomic associated with autonomic dysreflexia and nerve growth factor
2) Confidence 0.06 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 12542855 Disease Relevance 1.18 Pain Relevance 0.59

General Comments

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