INT108085

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AKR1C3) intracellular (AKR1C3) cytoplasm (AKR1C3)
Anatomy Link Frequency
HL-60 2
myeloid cells 2
AKR1C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 94.88 High High
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 93.64 High High
Leukemia 1 90.16 High High
Cancer 3 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated previously that overexpression of AKR1C3 acts to suppress cell differentiation and promote proliferation in myeloid cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AKR1C3 in myeloid cells
1) Confidence 0.53 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14996743 Disease Relevance 0.32 Pain Relevance 0.49
Here, we demonstrate that overexpression of AKR1C3 reciprocally desensitizes HL-60 cells to ATRA and D3, thus confirming the enzyme as a novel regulator of cell differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AKR1C3 in HL-60
2) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12543809 Disease Relevance 0.26 Pain Relevance 0.26

General Comments

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