INT108098

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 8.09
Pain Relevance 8.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
microglia 5
granulocytes 2
spinal nerve 1
tendon 1
lower limb 1
Itgam (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 65 100.00 Very High Very High Very High
Neuropathic pain 85 99.84 Very High Very High Very High
Morphine 81 99.82 Very High Very High Very High
Pain 155 99.44 Very High Very High Very High
spinal dorsal horn 12 99.20 Very High Very High Very High
Cancer pain 49 98.88 Very High Very High Very High
Thalamus 48 97.82 Very High Very High Very High
Spinal cord 161 97.66 Very High Very High Very High
cytokine 36 97.08 Very High Very High Very High
Duloxetine 55 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 203 99.84 Very High Very High Very High
Pain 235 99.44 Very High Very High Very High
Bone Cancer 54 98.96 Very High Very High Very High
Injury 273 98.72 Very High Very High Very High
Nociception 83 96.68 Very High Very High Very High
Hyperalgesia 254 93.04 High High
INFLAMMATION 243 90.04 High High
Adhesions 44 86.40 High High
Facial Nerve Injuries 4 85.80 High High
Attention Deficit Hyperactivity Disorder 5 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine also inhibited upregulation of CD11b with platelet activating factor ex vivo.
Positive_regulation (upregulation) of CD11b in platelet
1) Confidence 0.70 Published 2006 Journal Shock Section Body Doc Link 16680014 Disease Relevance 0 Pain Relevance 0
The effect of morphine was time-dependent, with significant effects first apparent at 4 hr after TG, but the administration of morphine 1 hr before or simultaneously with TG produced a similar increase in CD11b/c(+)HIS48med granulocytes.
Positive_regulation (increase) of CD11b in granulocytes associated with morphine
2) Confidence 0.67 Published 2002 Journal Inflammation Section Abstract Doc Link 12546135 Disease Relevance 0.24 Pain Relevance 0.84
Naltrexone completely antagonized the morphine-induced increase in CD11b/c(+)HIS48med granulocytes.
Positive_regulation (increase) of CD11b in granulocytes associated with morphine
3) Confidence 0.49 Published 2002 Journal Inflammation Section Abstract Doc Link 12546135 Disease Relevance 0.23 Pain Relevance 0.83
No activation of CD11b-positive microglia was detected around the retrogradely labelled neurons in the upper or lower limb regions of the motor cortex (Fig. 5).
Neg (No) Positive_regulation (activation) of CD11b in lower limb
4) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0 Pain Relevance 0.04
In 3 rats given freeze-killed grafts into the thalamus and killed 4 weeks after operation, no retrogradely labelled neurons were found in the TRN and there was no increase in immunofluorescence for CD11b (data not shown).
Neg (no) Positive_regulation (increase) of CD11b in thalamus associated with thalamus
5) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.06 Pain Relevance 0.12
In the literature, the most frequently described marker/antibody for detection of microglia and microgliosis is OX42 since the constitutively expressed CD11b is upregulated in parallel to the activation-induced morphological transformation of microglia (Ladeby et al., 2005).
Positive_regulation (upregulated) of CD11b in microglia
6) Confidence 0.36 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0 Pain Relevance 0.03
There was also an increase in CD11b immunostaining after tendon ligation (Fig. 6a, CD11b: TL-3 d and 2w).


Positive_regulation (increase) of CD11b in tendon
7) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.69 Pain Relevance 0.90
The masseter tendon ligation also upregulated the levels of CD11b, a marker of activated microglia.
Positive_regulation (upregulated) of CD11b in microglia
8) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.64 Pain Relevance 0.52
The immunoreactivity for CD11b, a microglial activation marker, was significantly increased in the ipsilateral spinal dorsal horn at day 14 after CCI (64.2 ± 1.7 a.u.) compared with control intact rats (29.8 ± 1.6 a.u.; p < 0.001; n = 4; Figure 2a and 2b).
Positive_regulation (increased) of CD11b in spinal associated with spinal dorsal horn and injury
9) Confidence 0.28 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 0.60 Pain Relevance 0.64
In 3 rats given freeze-killed grafts into the lateral column of the spinal cord and killed 4 weeks after operation, no retrogradely labelled neurons were found in the red nucleus and there was no increase in immunofluorescence for CD11b and no T-cell accumulation in the nucleus (data not shown).
Neg (no) Positive_regulation (increase) of CD11b in T-cell associated with spinal cord
10) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.07 Pain Relevance 0.12
Microglial CD11b immunoreactivity was greatly enhanced in the axotomized nucleus 1 week after injury (Fig. 1a, b) and reactive microglial cells surrounded the retrogradely labelled and ATF3-positive facial motor neurons.
Positive_regulation (enhanced) of CD11b in microglial cells associated with injury
11) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.18 Pain Relevance 0.03
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Positive_regulation (increase) of CD11b associated with cancer pain and bone cancer
12) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58
Western blot analysis showed that the pattern of increase in CD11b was similar to that of GFAP (Fig. 5d).
Positive_regulation (increase) of CD11b
13) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.58 Pain Relevance 0.60
NMDA receptor expression and phosphorylation were upregulated, as well as GFAP and CD11b, markers of astroglia and microglia, respectively.
Positive_regulation (upregulated) of CD11b in microglia associated with nmda receptor
14) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.90 Pain Relevance 1.26
In the same region, persistent upregulation of NMDA receptor NR1 phosphorylation and protein expression and increased expression of glial markers glial fibrillary acidic protein (astroglia) and CD11b (microglia) were found.
Positive_regulation (upregulation) of CD11b in microglia associated with nmda receptor
15) Confidence 0.21 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2914030 Disease Relevance 0.96 Pain Relevance 0.88
The spinal lumbar mRNA expression of ITGAM, TLR4, and CD14 was upregulated at 4 h post surgery, CD14 peaked 4 days after spinal nerve transection while ITGAM and TLR4 continued to increase until day 14 and returned to almost normal levels by postoperative day 28.
Positive_regulation (upregulated) of ITGAM in spinal nerve
16) Confidence 0.20 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15145554 Disease Relevance 0.42 Pain Relevance 0.35
The binding of CD11b on blood cells was increased 1.8 fold by the antigen, whereas on peritoneal cells the increase was only 1.2 fold.
Positive_regulation (increased) of CD11b in blood cells
17) Confidence 0.13 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.14 Pain Relevance 0.04
The histograms, in Figure 4A, show the increase in fluorescence intensity over the control responses upon the addition of PAF, as well as the inhibitory effect of feG on PAF enhancement of CD11b antibody binding.
Positive_regulation (enhancement) of CD11b
18) Confidence 0.13 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.19 Pain Relevance 0
Unfortunately, many studies defined microglial activation only based on altered expression of Iba1 or OX-42 (CD11b), which lead to controversies when trying to link microglial activation and pain states, because the direct role of Iba1 and CD11b in neuropathic pain genesis is unclear.
Positive_regulation (role) of CD11b associated with pain and neuropathic pain
19) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.94 Pain Relevance 0.90
On the contralateral side, the immunoreactivities for both CD11b and GFAP were slightly, but significantly, increased (Figure 2), as described in previous reports [32,33].
Positive_regulation (increased) of CD11b
20) Confidence 0.11 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 0.56 Pain Relevance 0.17

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