INT108131

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (GRHL3) DNA binding (GRHL3)
Anatomy Link Frequency
arm 1
GRHL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 16 100.00 Very High Very High Very High
Piles 7 100.00 Very High Very High Very High
Analgesic 4 99.90 Very High Very High Very High
Pain 7 97.96 Very High Very High Very High
Inflammation 8 97.56 Very High Very High Very High
Opioid 2 97.36 Very High Very High Very High
Central nervous system 2 92.84 High High
pain pelvic 1 83.12 Quite High
colic 1 12.96 Low Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anorectal Disorders 7 100.00 Very High Very High Very High
Pain 7 97.96 Very High Very High Very High
INFLAMMATION 4 97.56 Very High Very High Very High
Reprotox - General 3 1 83.12 Quite High
Fecal Incontinence 1 58.96 Quite High
Diarrhoea 12 53.20 Quite High
Toxicity 25 50.00 Quite Low
Reprotox - General 1 10 50.00 Quite Low
Injury 1 20.72 Low Low
Intestinal Obstruction 2 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other LENT/SOM proctitis symptoms were also more frequently reported in the escalated arm at all severities; this difference was statistically significant for grade ?
Localization (reported) of SOM in arm associated with piles
1) Confidence 0.73 Published 2010 Journal International Journal of Radiation Oncology, Biology, Physics Section Body Doc Link PMC2937212 Disease Relevance 0.66 Pain Relevance 0.52
Recent data show that GDNF modulates activity-induced release of endogenous SOM from both central and peripheral terminals of adult sensory neurones.
Localization (release) of SOM associated with somatostatin
2) Confidence 0.54 Published 2003 Journal Curr Opin Pharmacol Section Abstract Doc Link 12550740 Disease Relevance 0.18 Pain Relevance 0.82
In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory neurones exerts anti-inflammatory actions.
Localization (released) of SOM associated with inflammation, analgesic and somatostatin
3) Confidence 0.54 Published 2003 Journal Curr Opin Pharmacol Section Abstract Doc Link 12550740 Disease Relevance 0.20 Pain Relevance 0.84

General Comments

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