INT108170

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.97
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) mRNA binding (Tyms)
nucleolus (Tyms) nucleus (Tyms) cytoplasm (Tyms)
Tyms (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 74 100.00 Very High Very High Very High
palliative 5 98.72 Very High Very High Very High
adenocard 8 96.20 Very High Very High Very High
Arthritis 27 90.40 High High
Inflammation 3 59.16 Quite High
dexamethasone 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 61 99.64 Very High Very High Very High
Colon Cancer 12 97.28 Very High Very High Very High
Solid Tumor 21 92.64 High High
Arthritis 3 90.40 High High
Rheumatoid Arthritis 11 86.56 High High
Toxicity 40 85.96 High High
Disease 48 81.12 Quite High
Juvenile Chronic Polyarthritis 23 70.88 Quite High
Alopecia 1 67.52 Quite High
Glioblastoma 1 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INTRODUCTION: Thymidylate synthase (TS) and p53 expression have been reported to predict the results of palliative chemotherapy in advanced colorectal carcinoma (ACRC), but the knowledge is still limited and partly conflicting.
Gene_expression (expression) of Thymidylate synthase associated with colon cancer and palliative
1) Confidence 0.69 Published 2002 Journal Anticancer Res. Section Abstract Doc Link 12552972 Disease Relevance 0.25 Pain Relevance 0.10
INTRODUCTION: Thymidylate synthase (TS) and p53 expression have been reported to predict the results of palliative chemotherapy in advanced colorectal carcinoma (ACRC), but the knowledge is still limited and partly conflicting.
Gene_expression (expression) of TS associated with colon cancer and palliative
2) Confidence 0.69 Published 2002 Journal Anticancer Res. Section Abstract Doc Link 12552972 Disease Relevance 0.25 Pain Relevance 0.10
Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma.
Gene_expression (expression) of Thymidylate synthase associated with cancer, colon cancer and methotrexate
3) Confidence 0.69 Published 2002 Journal Anticancer Res. Section Title Doc Link 12552972 Disease Relevance 0.20 Pain Relevance 0.14
Evaluation of the pyrimidine pathway has focused on TYMS, primarily a tandem repeat sequence in the 5?
Gene_expression (focused) of TYMS
4) Confidence 0.47 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.59 Pain Relevance 0.37
However, for the subgroup who initially had curative resection (Dukes' A-C), TS expression had prognostic information and significantly predicted time to recurrence (median for low TS tumours 30 months and for high TS tumours 11 months, p = 0.001).
Gene_expression (expression) of TS
5) Confidence 0.47 Published 2002 Journal Anticancer Res. Section Body Doc Link 12552972 Disease Relevance 0.06 Pain Relevance 0
Preclinical data showed that Vorinostat is able to downregulate the expression of thymidylate synthase (TS) in tumor tissue.
Gene_expression (expression) of thymidylate synthase associated with cancer
6) Confidence 0.06 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.62 Pain Relevance 0

General Comments

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