INT108172

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.64
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
Anatomy Link Frequency
HTC 6
cortex 3
liver 2
hippocampus 1
Abcb1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.44 Very High Very High Very High
Morphine 22 99.24 Very High Very High Very High
Paracetamol 3 94.28 High High
Bile 11 85.08 High High
Bioavailability 1 59.28 Quite High
Angina 1 52.20 Quite High
ischemia 18 5.00 Very Low Very Low Very Low
fibrosis 15 5.00 Very Low Very Low Very Low
addiction 15 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 6 99.74 Very High Very High Very High
Liver Disease 2 99.16 Very High Very High Very High
Poisoning 2 94.80 High High
Gallstones 2 93.08 High High
Extrahepatic Cholestasis 1 92.44 High High
Pressure And Volume Under Development 81 92.28 High High
Overdose 1 75.00 Quite High
Stroke 1 52.64 Quite High
Cv General 3 Under Development 1 52.20 Quite High
Targeted Disruption 6 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the Mrd1a and Mdr1b genes encoding the P-glycoprotein (P-gp) also increased in the whole hippocampus and cortex of morphine-treated rats.
Positive_regulation (increased) of Gene_expression (expression) of P-glycoprotein in cortex associated with hippocampus and morphine
1) Confidence 0.67 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.67
It is concluded that the hepatic expression of mdr1b is increased in the experimental liver diseases when compared to controls.
Positive_regulation (increased) of Gene_expression (expression) of mdr1b in liver associated with liver disease
2) Confidence 0.43 Published 2002 Journal Acta Gastroenterol. Latinoam. Section Abstract Doc Link 12553158 Disease Relevance 0.71 Pain Relevance 0.34
The expression of the Mrd1a and Mdr1b genes encoding the P-glycoprotein (P-gp) also increased in the whole hippocampus and cortex of morphine-treated rats.
Positive_regulation (increased) of in hippocampus Gene_expression (expression) of P-glycoprotein in cortex associated with hippocampus and morphine
3) Confidence 0.23 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.67
The P(app) values of TSB in the BL-AP direction were significantly higher in MDCKII cells over-expressing MDR1 or MRP1, but not in cells over-expressing MRP2-5, as compared with the wild-type cells.
Neg (not) Positive_regulation (over-expressing) of Neg (not) Gene_expression (expressing) of MDR1
4) Confidence 0.13 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.10 Pain Relevance 0.08
The same group later reported that MDR1-overexpressing cells (HTC-R and NIH3T3/MDR1) exhibited an approx. three-fold higher level of ATP release which was sensitive to the MDR inhibitors cyclosporin and verapamil [70].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MDR1 in HTC
5) Confidence 0.08 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.26 Pain Relevance 0
In hepatoma HTC-R cells overexpressing MDR1 protein, an increase in the whole-cell current (carried not only by ATP but also by Cl?)
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MDR1 in HTC associated with hepatocellular cancer
6) Confidence 0.08 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.28 Pain Relevance 0
In hepatoma HTC-R cells overexpressing MDR1 protein, an increase in the whole-cell current (carried not only by ATP but also by Cl?)
Positive_regulation (increase) of Gene_expression (overexpressing) of MDR1 in HTC associated with hepatocellular cancer
7) Confidence 0.08 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.28 Pain Relevance 0

General Comments

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